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NBME 22 Answers

nbme22/Block 4/Question#44

A 10-year-old boy has bruised easily since ...

Prolonged prothrombin time

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You can basically think of Dicumarol as warfarin. MOA: Depletes vitamin K stores Since Vitamin K is involved in gamma carboxylation of factors 2, 7, 9, & 10, you can use the Prothrombin Time to measure the response. Prothrombin time measures the extrinsic pathway of coagulation, which is mainly mediated via Factor 7.

 +4  upvote downvote
submitted by seagull(448),

If you don't know what Dicumarol does like any normal human. The focus on what aspirin doesn't do, namely it's doesn't affect PT time and most pills don't increase clotting (especially with aspirin). This is how I logic to the right answer.

usmleuser007  If that's then thinking, then how would you differentiate between PT & PTT? +2  
ls3076  Why isn't "Decreased platelet count" correct? Aspirin does not decrease the platelet count, only inactivates platelets. +  
drmohandes  Because dicumarol does not decrease platelet count either. +  

 +0  upvote downvote
submitted by zpatel(6),

Can anyone tell the effect of aspirin on a blood lab value (i.e PT,PTT,Fibrin product)?