I think lato of eplpeo thgmi vhea erov amdezsphei who mirapntto NPA adn PNB lralye era, eys ti is itpromnta ot konw ehets pspdiete etg esrdecte yb hte ncrrtar/lvleiautia aumryidmco inurdg treha .ilaufre rowveeH etrih learovl enescsftefive ni genttari hetar laeufir si clh,iz a repetocpr ltdo me ttha if ANP adn PNB reew os fsuule in suesntaiirr hten hwy do we vegi duscei?itr 'tsI bcesuea RSAA esrvowproe siht ytssem echen icgnsau tneeivga ecfsetf and teh esldnes lpoo fo arhte realf.ui AKA wyh we evig CEA .inostibihr

inowgKn thta PAN setg enladtzruie by hte RSAA ,tsmeys we nca stfih our suofc abkc ot rahet ifleuar ni isth petitn,a where ccaiadr tputou is e,ecesrdda lnaedig ot AHD eneocirts adn fllinay iutaiodlnl mnatayoiprh.e

I sloa htgthuo teh maes sa ub@b,esbl utb onw tnyrig to "jytif"us isth ycitrk MNEB iosu:nteq I hnkti this evsleorv no het tfca ttha the aptenti ahs a IHHG oobld uprsseer eiamnng ew uhdols csfuo on an wneasr htta lexnaips otbh needcsari PB dna Homoaeiplyv e.i:( sadieecrn HAD cwihh vctnitorsacsos adn osal osarbsb r-ewea,fert btoh fo chhwi ecsinrea BP dna sacue a)ohmevy.poli

aeybM fi tish naietpt erew etondamsdcpee hwit OWL PB, neo ucodl tkhin emor abtuo .NAP

I tlils inkht htsi ontseiuq si TOO .yctikr

Fomr a:otTDUpe PENGOHTSISAE

keLi tmos orhet sceusa fo ipty,omaeahnr rtaeh lfreuia rspamii eht ibytila to rxetcee gsniedte etarw by nceinrgasi ectiidnritua mroneoh evlle.s eWnh ardacic outupt and esytmcis olbdo rrpsusee era ucr,deed h"pocy"eomlvi sromh,oen ushc sa irenn t(iwh a snsteuequb rcaiesen ni enostnigian II oomfi,)anrt ceditanitrui noerohm (D)A,H nda pnenn,ieihrepro ersdpno []13.- lhoAghtu esteumdoa sptatien ithw retah eirlfau eahv cianrdsee mlpaas nda cetlrlaleurax udfil mulv,eos eth oybd ceresievp evlumo leinpetod cdurde(e feieecvtf taaerril olobd l)vmeuo censi hte low accdiar ttupou sraesceed teh sspeuerr snfrpegiu het orerbposaretc in eht rotaidc inuss dan eth enalr atfeenfr h orral.eTiete geered fo uohauelrormn tctoanivia si ngelarlye tdareel to hte servyite fo darcica fsydotciu,nn sa sssesaed by ftel renrlaiutcv ctoejeni cirfaont ro ulnfnaocti cslsa [2]. hTe lraorunouemh acensgh litim htob siudom nad ertaw iecxeontr in na tetpmta ot uernrt nfropsiue sreeuprs to ol.armn AHD raeesel ictryedl hsenncea erwat srbpriaotnoe in hte citeclognl btue,lsu reshewa sgientinona II adn reeneniorpnpih iimtl tdaisl awret vireyedl dn(a yberthe rewat toce)enrxi yb iwrnelog eth emuarlglro ratoinfitl ater d(eu ot a kraemd ectirduon in lnrea )rfusoipen and by sraiigcnen xmoliapr umiosd dan aerwt oobirrtepasn .[4] nI io,tnaidd ohbt eth owl rcaacid puttuo dna hihg otanninsgie II svelle era noeptt uistmil to shirt,t angleid ot ecdhnane tarew eintak.

wu-claemnstttspwedhafohyrtt:ai-n//re.nc/wwte2pphie.nnar-hto-titoai-#/aiseuttoHmp

ishT tnqisoue edsufonc me a lot eacbsue so nyam otusneqsi ehva idlredl em on hte ieparcotmn fo eth ANP apeecs nemmhcais in ietms fo dfliu aoedvolr as( ni C.)HF

I ohugtth ANP aws a gehu erpyal in eht osls of Na ni etnsucrsiaccm of vlueom ovelodar sa in siht teanpti ichh(w si yhw ouy ese celuveoim atmehipyarOn in epatstni thwi AHSID or eytvoraivcit fo hte RASA as in .H)FC

yhW si AHD onw nbige aemdn as hte rslpeoibens e?ntga

FCH ptitasen efotn dysipal nssgi dan psytosmm of eericsnad issvperason neic.sorte

eerH ew go:

• ddaecseer VL cyottltiianrc rableil(ta lscc)rkae
• seceardde diacrac otptuu
• atvcteai RSAA → AHD
• isecrane mhtseyictpa yiacvitt → emor ASAR → orem ADH

cnowtbg.h2me0u8l/i.p/w8:2dhbwpmnn/7.sit5/.v

n"odsyrme of lu"dnloitia ll"yoypa-tmosioh ni versee itvsecgnoe hetra ufrlaie may eb decsau yb an pneyliripptaora ihgh ADH ieecosrnt in ihchw the opeoorrtscme yssemt si indmdeoat yb nsloaonmor imi"ulst

noyiparHmeta romf iHetfeaurlar tp.

It udshlo eb rpceopaadh fmro rteaH .uearfi

;Ht-F&g AARs ;&t-g isxceeevs l,eAotdoerns H;DA PAN epcsae urf,aie klie reydncsao dptessra;rminholyeo aytmpiaroHne

g.-9//lv-7g.:fh05w2l9Wc4///mwo8/5s9tmp-t0i1/1-3Jtn1jwuhCet.w64

cetopemDaesdn .FH cLka of obdol flow due to glafini treha tg&-; ewolr BP &t;-g dsrnceaie DHA to raceensi oobld suesrrep cabk to satbel ee.vll nI FD,H HAD staepcou ishssmaotoe fo iaoucncerttng APN m&;ap NP.B s,uhT teh rmet se"ad.c"tmdnoepe asAdeoistc htwi hneorssts fo areb,th meaed tof(en of sun)gl.

shiT cuivsio yccle ctisuneno sa yobd iirzopitsre adeuateq BP for alivr,suv ubt ti smceo at eht speexen of kovedeorwr eahrt that ustm orkw hrerda nda hredr,a yemuatltli cebeiatrgnxa hte aerht eailurf tic.idnnoo

Alwasy kwon tshi yHop or eayaepnritmhr si acebseu of ngchae ni teh vuol,em hist tpaetin is ggino gorthuh htrae leaifr,u neral uorensfip hsa enog down ttah dslae to lreaees fo HAD cos fo pssorrtcoeoem ioi.utstnaml owN ihhg DAH liwl roabrseb roem eefr artew atth llwi lead ot .minpraotahey oS paotnihrmyea si stmoal alwyas ldrteea to ihhg AH.D I kwon wef of yuo llwi hkitn ubt ARSA stsmey is teaactvid oot btu ttha bosbra Na ngoal hitw rewat btu DHA sutj reef w.trea

i iankd fo eefl "dd"o ingkas iths suqnoite : ubt the ptntiea hda na IM 6 otnhms gao, os yhw wlodu it be lkeunliy htta eh saw tlod ot crsertti" ,ltsa rtcierst ufslid (tewr)a " ??

Geuss whta mi' kgsnia is : thaw esakm iheocc E ushc na llkeunyi cochei DJ,V( birsilbaa- lskeacr,c rihpaperel dmeae) ?

&;pam sgni@netiim : hsi pb si 52381/ mgHm ... ywh si tath GI"H"H ??

Frtlisy, I ohcse DHA. ehnW I totghuh icewt ni veier,w I ekdicp dscsreo HDA nad pdkeci AP y.MN oilgc ot socsr : 1.AHD hTe mnia rindecu fo HAD rae mOs and P/evlB.mou TsHi ,tp smO yovislbou ont ig,hh pB byoovusil nto wo.l ,oS nsnsnoee ni edscirane . HuD2Y.Ao mya see AngII sola dcuensi D.HA But it messe ot be a morni .cndiuer lManh,eiwe fi it si xtclyae hhgi n→IgIA hgih DHA. Te,nh oldA mtus eb ihhg sa ,lwle nda iHgh dAlo taSl→ igrrsneev→p OHW CAN msure idSoum be wL?WL O"o daaicCr →tpoutu Hhgi SSAR (gInIA lAdo )D"HA yptawah si IAUSRDOTMEW- rtn.neoeti NTO puer RAEWT oeitetnnePs lrae eortcrc em