NBME 23 Presentation of antigens to CD8+ T lymphocytes (NBME Answers)

NBME 23 Answers

nbme23/Block 1/Question#22 (reveal difficulty score)
An investigator is studying the adverse ...
Presentation of antigens to CD8+ T lymphocytes 🔍 / 📺 / 🌳 / 📖
tags: immuno repeat

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submitted by ∗sajaqua1(607)

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MHC I tnfonicu is renagilt to cnaerc psruon.sspie CMH I pyasidls gsoenlnydueo ydhesseztin stieoprn dna rnseteps ethm ot D+8C T els.cl hTe eaflrui ot alsiydp CHM I, ro CMH I dpasyil fo nf-senlo ad(n by eoextnins ccosa)eunr ipntores tgsgrrei a ulrlelca emmniu p,snroese lgidean ot nticudorset of teh c.ell

The smaoreoept si uesd rfo eht tnreadaodgi fo nwro ,tuo ntessceen, or lfmeaomdr n.irtpseo As cranec pvelds,eo reom itnamtosu deal to endriaesc nrgow nptoreis. lynO yb osesepinrx fo het reaomo,tpse or sit xneio,-seopsvrre cna sethe nttuam oreitnps eb deadrged afts ehognu ot not be idpsleday by CHM I and dlea ot teh lcle gineb i.dllke eBozmtbior obsckl eht soet,eamrpo os hte amtntu sineptor era lddpeaiys no teh sur,caef wlgaioln the mneimu smseyt to regozicne dan lkli talcaopolgih sl.ecl

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catch-22 nerthAo way ot rchaaopp ti is to nitkh botua MCH lcass I eni.rpocssg aBs,yaicll fi oyu ihniitb hte meaopstero, dppsteie illw tno be eateerngd nad oghtinn is laevaialb to eb edaldo onot MCH I rembem(re HMC I sha ot eb aeoddl eerfob i'st nteoratdpsr ot het ecll cuaesf)r. Cells atth dton' resespx CMH I teg kildle yb teh rutanal liskl. ertsba/Mpcp/c.t/nilego/cniCw/Pw12.ni67r2.mshw.tm/:h43vl +32

kai n"I sc,onociuln we aehv dtmtdoreasne atht the premtoseoa otbirnihi rembbiozto eelogwtadsnru- sascl I nda cnhanese het ysiviinetts fo mmyealo ot KN ld–eeemdclita sl"ysi rfom eht icnulocnos of eth IHN praep +6

maddy1994 thaneor anemhsmic is yb nkbgiocl pmtooeoers u evne aesdrcee rntgdoaei fo tpopaopcroti .prseis.ont.o it hecannecs spmaoo(stirpof dlruo)w +6

azibird utB C+D8 nda KN sellc llki iav !prfonrie Why is siht resanw o?gwrn Is ti aubecse its' tno teh mayprir ecffet? +2

testready eh"T aortmopsee is eth armoj secoru of petooclytri tiyviatc volevnid ni hte tnanrgoeei of pepdesti fro isarneepntto yb mjaor yoimtiptbsiichtalo mlxpoce cslsa I o.mclelesu eW opertr the new rbtvoieanso thta imztbboeor twenlouaes-grd HLA slcas I on MM selcl, nesrltugi ni aneidrcse NK cltmiade–eeld .sli" syopllvbwi.//.Cwprnm//swetP.cMg/3thnht264/7s1mciacn2:i. +

fatboyslim I kihtn hwta PO sdai cdorittcnsa hitw athw 2a@h-t2cc dteci ni hte PudbMe erlc.tai +

an1 OP asid "lnOy yb xenspieosr fo the epeoos,atrm or ist s-eorvrne,ieopsx nca seeth utatnm otinpers eb adedergd ftas ghneou ot not eb apdlyside by MHC I". WU IQD 14671 ayss thta a ieptnro ndsgureoe dnitrgaeado by het inuitqubi saepromoet ytp,awha aefrt ihchw it soge ot hte ER nda neht si rdpesetne ot hte ecll rafcuse orf MHC 1 pronsese gladine ot psoosiapt avi mprforse and maznesyg.r viHagn a amprseooet irhibntoi owdlu lutcyaal pnervte the HCM eropsesn cubasee on oinpters rae y.sldiapde lAso etno htat eth inqestou assy cwhhi opscesr liwl eb fdat,efec heert si on oietnmn fo iacneers or esrda.cee So e,ys teh MHC /1 DC8 hatypaws si ,fceadtfe utb si't ulytalac ownd .edtalregu nA baescen fo MCH 1 dleas to KN llce aededmti d.eath +

"Studies have shown that proteasome inhibitors block the assembly of MHC class I molecules and this is almost certainly because they are stopping the production of presented peptides that are needed for this process (6)." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094101/

+3/- donttrustmyanswers(74)

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submitted by ∗tinydoc(276)

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tu3/Huosp:z/thbem5tUIJ/.fRyh

OMA of opmeortoes hiitosribn rof MM. :RLTD si htat yhet scliaaylb lcbko the omoeteorsp rfmo noncfntugii os atht eaoymml clsel t'nca ecrclye ioernpts t(eyh amke a nto fo tem)h nad enhw htye 'nact eb ceycrled thye bilud up dna stath ocitx ot hte clle dna ti isd.e

yonedb htta eth enostiuq si aaiscbyll nikgas if eth iobinthini fo osompoteers tins pcesiifc to the alMyome lscle nad it heiibidtn otrhe 'lselc toesopemors twha luwdo be c?dfeftee

MCH csals I is nserept no lal eatnlecud lelcs ll(a escll in eht obdy xeecpt R)BC nda otfnucin to snterep oeeusnngod inngteas ot 8CD+ t eclsl ot eb seertodyd fo(r pxeelam lVira ADN ni an etfdecni l.cel) Teh ywa etyh do isth si by gnatki eth nrptieo ti dnsee ot ntrpsee dan krgaebin it dnwo itno hcum llemars epiptde ianhcs s(o it anc tfi no eht M.HCI fI hsit pest saw nihdebiti in htroe ecsll etnh eht the antotisrPnee fo MCH I otnuwdl eb eabl ot epenrts rthie gneitnas to +CD8 T eclls dna aNatlur rillek s.llec sa eth eqsntuoi iesmipl.

eTh qnoeisut wsa prsue rctiky saucebe fi ouy 'tond nokw owh remseoootp ishribtion rwko ehtn uoy ratst ignoklo for na waners that uwdol nailepx ohw yeth lowud klil rotum clles sa .ewll I got it rnwgo t.oo tI ediequrr egekdlonw of the ywa HMC I etsnspre ei.esdppt

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submitted by ∗krewfoo99(115)

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Why dluwo rrnsioefp eb the wnorg ?rwsane uWtlodn numuaaictcol fo icotx pnitores acsue eht llce ot rndgueo pitoaopss ?

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ergogenic22 zeBrbmtooi sdoe not ldriyetc tiaevcat rrpfo.eni tI deltryic iitnibsh eth ooasepetrm hhicw → abseenl +D8C T llsce ot natetiii tipasosop → iva rniorfpe eaerels (ni snesece a rdaeswtnmo feecf).t +4

drzed ay,txElc ti ietsggrr eht eclls to dnoergu tpopssaio chwih nsame htat ti cna hiteer be cell edaetmdi (oriepfrn dan zagemrny vai /ASFF)LSA RO it doclu asol eb uoghthr het ristiicnn waytpha e..(g imhdora;cnotil oeyhmorcct c) +

powerhouseofthecell tiQonseu: utB ohw od CD8 llecs vhea a loer ni siht secposr cyxtela ni eth ?etentgiv sI ti siayng ttha enhw hte ntispeor dilbu up, lyno nthe od 8CD lelsc omce dan nidseat of CHM I etrngenips ot mte,opsroesa eyth espentr ti ot C8D to atiiietn toapo?sisp +

flexatronn heseoce@frophlotuwel os ti all ogse bakc ot icsab mnmuio i( tgo shit nrogw nda put oaitpspso sa l)elw utb rtafe niigvwree tavelern naki sadr,c i wno tge t oi.S oaopeemsrts berka odnw gaedgt tnsrpioe hnwtii hte lelc o.onesun(dg)e The rkewadbon puocdsrt teg tkena pu by trpoasrtn acsaditsoe hiwt ngaetin pisegscnro T()PA adn hotgurb ot the rohug E.R The bernwdaok osturpcd rae enth daedlo otno CMH I uslcoleme nda oburtgh ot hte sfrceua of hte e.llc nehW gnitkhni tubao CHM ,I ktinh uoabt C8D+ T eclls (FA HMC 1 x 8 = wNo.D8 C to mi,suazmer wenh sngiu a reospemtao i,rtiinobh ou'yer lcgnikbo ttah gagtgin nad CMH I doginal ocespr.s As tdaest roe,fbe D8C genoisecrz MCH I hw(ich 'tnow hanepp nwhe isgun these ugd)sr +3

whosdaprincesss ontaln@efrx ankht yuo !!!! +

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submitted by ∗abhishek021196(119)

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obmt,iorBez ricmliobazf

iescmhnaM = oeetmoarPs bnroiit,ihs uidnec rteras ta M-G2 epsah dan apspi.otso

esU = uliMlept aoye,lmm aeltmn elcl apmol.yhm

vAd scEftef = hpilrarPee auyptrnh,eo sreehp oerszt coniaairtevt

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tyrionwill eundr ori,boBtemz the omretsopea oacnnt tsgedi lariv gA dan etrsenps ti ot teh enaber-bmdondme C.HI-M rreeTfheo 8D-cCT cnatno zgiencreo het ohts clesl tniinacgno esradlep Z.VV tTha is roaybblp ywh ghnsiles is eon fo the lproapu seid tecfef fo reiBozm.otb +

kcyanide101 Teh gudr siibhtni rteopomoes. eHnec teehr si no ngartmfe alialbave hortghu TPA seidni DC4 elcl to adol uotn HMC ...I. sA chus hte DC8 aersnntoitep ot lcTle is rveepned.t ehT mlinutagcuca nrtispoe iedins het 8CD ellsc cihhw aer ton beign obkner ndow yb the repooemsto ucesa it to gonderu ppoosstai +

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