NBME 22 1 in 600 (NBME Answers)

Retired NBME 22 Answers

nbme22/Block 2/Question#34 (reveal difficulty score)
A 30-year-old man and a 24-year-old woman ...
1 in 600 🔍 / 📺 / 🌳 / 📖
tags:

+27 upvote downvote
submitted by ∗drdoom(1206)

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taaCosllcuin rfo dad. eTh ytiirolbbpa of eth hfater nbeig a iacrerr si 2/3 snice it is knnwo thta eh dteson’ evah the dee.issa eTnh the ioabrpblyit of imh asigpns it on to shi kdi is /,21 :tsuh

britlbPiayo of add ignbe rarcire = 23/
iPblbyiator of add gsinasp on adeessi aleell = 21/

ualtnoscaCli rof mom. tiWh het gbWdeneryiHra- icrl,Pipne oyu cna urgife otu eth ribbyptloai of het etrhmo bnige a eaic:rrr

q = 01/,)q0t(0rs40 = /2001

,oS 2pq = 2 * 2/010 * /099012, iwchh si pxopar .10/01

For the ichld ot etg teh aeelll mfro ,omm two nsihtg ndee ot epp:han )(1 mmo smut eb a creiarr yo“”re]o[gezhtte nad 2() mom mtsu spsa eth aeelll ot cli:hd

Ptybibrolai of mmo gebni crearir = 0011/
lioyiabtPrb fo mmo npgssai on aisesde laelle = 12/

Pgntiu ti lal hotegert. wNo, imoebcn lal ohg:ttere

= (pibyoiabtlr fo dad ngebi rearric) * ailbytbp(ior fo add naipgss no disseea leae)ll * bpiloybi(rat fo mmo iegbn e)rracri * (rbiapotyibl of mmo igsnaps on siedsae ellla)e

= 23/ * 12/ * 10/01 * 1/2
= 1 in 006

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kernicterusthefrog To uqote yThrgo or,hT rdga qneeu: w,"e ssJ,ue sgrso" +52

niboonsh sTih tuoineqs skema em tnaw ot vtimo +14

drdoom lol +

5thgencephalosporin ykao wwo +

tekkenman101 uoY nca akme ihts a lto irukqec yb ungsi lemips leurs ofr sumotolaa rsieevesc adsse)1.si e dUfnftcaee anretp tiwh afecetfd aienegl llwi be a erarirc /23 fo eht eitm 2( Aa)) feecuqnyr in inpltauoop is userp low os yuo cna groien P and jstu eus q2)( ni oedrr ot cltcelaau cearrir .ynrceufqe oS take het aesurq otro of hte ghoymouosz csreeevsi fcynurqee 000)(4,0/1 adn usjt gpul it in: 2)0(5.0 = ) 0.13 The sodd of htier dhicl bneig faectdfe iwht hte tow taenspr ienbg essdamu iyhlthcaepot ieacrsrr si 14/ aa)( ro ad.' 2.5Ds rarriec henacc 2(3/) x Mosm' rraeicr acchen )(10. x dicsl'h chanec of nibeg esrvsecie (5.)2 +1

Instead of doing all those calculations for the mom, you can also just multiply the dad's probability by 1/200 → q, the probability of the allele in the general population

+1/- hungrybox(1277)

+4 upvote downvote
submitted by ∗keycompany(351)

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lnnidaeaM Gese:ntic

nMa ahs 23/ echcan fo niegb a r.eiracr eH( osde nto aveh eht s).aedeis a noWm rcareir sikr smut be ductlecala iwht ^p2 + p2q + 2.^q q2^ = 001,0/40 q = 0,210/ p si ulyoghr = pq21 = /0110 = rrraeCi efuycnreq .

Risk fo gihvan a cdhli hstu saeqlu 32/ x /0011 x 1/4 = 6010/3a:Bee us2 c/ = naM Cairrer ikrs 100/ 1 = leFame riearrC si/Rk 14 = naChec etyh ceah sasp on eth sesceivre nege to hteri fgo.nsrifp

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hello See my eiotalpnxna if you nede omre owdrs ot ielpxna itsh xlopnetanai +2

+3 upvote downvote
submitted by ∗hello(429)

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sTih teh amse sa seckpoy'mn@ay eaonnltiapx wiht eomr nlanapoteix thseo ttha need i..t.

ehT itptnae is ateffdcneu by eth uairclptar suaamoolt esvsrecie sedesia nda ihs ebortrh sha hte solomuaat eecssvrei ediesas ;--&tg isth sname aceh of irhet asnrtep reiacsr the AR eellal. o,wN fro the eptanit to eb feceutanfd nigev htta btoh ish tsnerpa vhae teh AR ,eellla ti anems ahtt eht inptate has a 23/ cahcen that he si ylleiuanussmto dncuetffae nad a rceir.ra

ehT stpetani' aperrnt is ancdeuefft dan nlmora deyeHrgWia-nrb ntcseieg s(a tatdes in het .ehwormbl)pen. shit si siilepcylacf etnmniode, uoy ear to eamssu ttha eht rrnatpe sha a rreriac cfyqerneu rof eht AR elal,le hichw lquae ot .pq2

heT sdaiese ahs a cenqyuerf ni the oituoppnla fo /.010400 sThi si 2^q t--;g& ^q2 = /00.0104 ionlvSg rof ,q you egt q = 20/.10

rrerCia ncfureqye is .qp2 oHvrewe, for a rear ieasd,se qp2 ≈ q.2 So, eht racrrei eyerqcnuf rof teh etrrnpa = q2 = 2 * 0210/ = 01./10

Nw,o eht Q kssa auotb an ponsgirff of eth etniatp nad hsi prenatr igenb cfaeetdf, so to hvea an feedafct cdh,li herte is a 41/ hcncae fo aignvh na aetedffc ldihc c(euassbe hte ipantet and the tpreanr obth veha a 12/ eanhcc of piagssn het llelea ;g-t-& ouy upieltml ehste erogthte 12/ * 2/)1.

So, yuimtllp 23/ * 01/10 * 41/ = 0/1.60 sihT si (ptiPtean egnbi a ri)crear * nePrprat( eginb a r)aricre * nagivhP( an fcetdeaf fosrpgnfi otrgte.he)

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+0 upvote downvote
submitted by beastfromtheastx(0)

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Teh ilbprtoibya fo hte faehtr bigne a acirrer si 23/ sinec it si nknwo ttha he snet’do heav het esa.ised henT eth tiyrbaipbol of imh nspisag ti no to hsi kid :is

1/2 * /32 = /31

tWhi eth drrn-yaeWHbgei nPiercli,p yuo nca riuegf uto teh blyioprtiba fo het etomhr enbig a ce:rirra

q = 0r0/40s0,t1)q( = 0021/

,So p2q = 2 * 1/200 * 010/299, hcwih parxpo is 1/,010 and teh priyobiatbl of eht dlhic gintteg isht eellal si 1/010 * 2/1 = 0021/

:uhsT

0201/ * /13 = 10/06

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brill45 ouY idd shit hitrg utb I hkint mdae it a bti oerm aieccpldomt tnha ddenee to eb. oT guerfi tuo eth llkodoihei of a rdnmoa prsnoe in eht pioanputlo snpgais on a erevcseis eelal,l you usjt eden ot od e(a2)rquotqrso to etg ot q. dAn tsju seu tath q to lmpuylti wiht teh /13 yuo gto lria.ere hTe q lveau llets yuo eth lleale yeqcefrun ni hte ti,poloanpu thewher het nesrop si a rarrice or zhmyosugoo eecevssir tb.ho oYu illts tgo ,it tbu stju netlgit you onkw eht sereai rtoue in aecs you see it angia! +2

+0 upvote downvote
submitted by kdckjn(0)

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ywh tereh si ptryblbiiao of ahrtfe beign a irrreac is /23

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drdoom eW muessa hist si a sveceiser d.aessei nI htroe dwsr,o you simaften teh eiseads fi oyu inrihet a eadseis eallel, ,d form yuro hoetmr adn a seadesi lleel,a ,d ofmr ruoy eartfh, gnivig ouy an lelale iirgnpa ndedteo yb dd. dd = uyo aehv eth esaie.sd ehT htafre does nto veha hte asei;dse itsh nsmea his pegnoyte acn onyl be 1 fo etrhe sthn:gi D,D d,D ro .Dd Taht si, DD = D rmfo ihs add, D omrf ihs m;mo Dd = D omrf ihs dad, d mrfo his m;om ro Dd = d omrf ish add, D fmro hsi mo.m itecoN htat ni onyl owt of hseet 3 isiiliptssboe odse hte aerthf yle(opani)ttl veah a esiesda elelal ()d ahtt eh ihgtm assp no to ihs .ynprgeo +

We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by “dd ”).

dd = you have the disease.

The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.

That is,

DD = D from his dad, D from his mom;
or Dd = D from his dad, d from his mom;
or dD = d from his dad, D from his mom.

Notice that in only two of these 3 possibilities (⅔) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.

+1/- drdoom(1206)

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