NBME 22 Decreased binding of RNA polymerase (NBME Answers)

NBME 22 Answers

nbme22/Block 2/Question#35 (reveal difficulty score)
A 45-year-old man with Li-Fraumeni syndrome ...
Decreased binding of RNA polymerase 🔍 / 📺 / 🌳 / 📖
tags:

+67 upvote downvote
submitted by ∗seagull(1933)

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Did yennoa dene ot erad ahtt alts tenescen eikl 05 tesim ecsbaeu het utohar seerufs ot seu erbtet .aargmmr tusJ fua.nitgtrrs

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link981 orhutA eaatli:orn hat"W is a?"mrgamr +6

qfever Did oenyna eard klie 05 imets and lslit gte ti wong?r ,(LLO )me +22

drbravojose ylltcAau rveen rnedadtsnu thwa teh ahtrou sygian ta nya e.tim LOL +3

alimd Such a ihttys q.seuotni Do ew yalrle vhea uchs qesnsituo no the arel ae?xm nI ym iionpno hyet tsuj hortw uknj estnoqiu ot sthoe easmentsss +1

nootnootpenguinn Oh ym oon-edsgs hnkta you! I asw os mda ta worehve weort hsit siytth nuq!ietos t(oG ti ngwro o)ll +

xmen THYE VIEG EIMSTEMO WEDRI QEINSTSUO DURNIG EHT EALR AXME D A!N!! SIT' EMETARXLIPNE +

+12 upvote downvote
submitted by ∗hello(429)

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The mararmg fo eht aculta Q aws n.focnusgi

oT aemk rteetb ,eness ti dusohl sya iW"chh fo hte owinglolf is teh sotm kyllie lrsetu no eth rntcsipiatnro fo gnese taht ihtnibi clle iidonivs and atht nncoita eht cnnsseosu nsqeeeecu "AAT.T..

oS, eht Q is nikasg tabou teh p53t eneg and iciyelclpsaf aotbu hte 5pt3 eeng roprmeto nerigo.

Ptemrroo ongsier ahev a TAAT box b,soy(viuol imengan rhci ni A-T sbae sa)pri. AT- bsea niigpra ahs 2 eohyngdr ,bdons wihhc kmaes mhet arseie ot lveace -;&tg- llsowa rof NDA pntrctainiros to ccruo oemr iaes.ly RAN oPl edso tnrnciisatpro fo NDA toin AR.N

hTe rteein -mseQt asltk btaou hwo irauiLFmne- si eud to a utmnotia in p53t n,eeg inegald ot a lkac of otrum psspnreiuos tctivia.y

,So if hte omproter einorg AATT xob fo the 53pt gnee is admte,ut enth het t3p5 eegn lwil nto etg eadncrsitbr ;--tg& tihs is hwy ehter lwli eb ecsredade ANR lPo idg.bnni ANR lPo lwil eahv a udceerd liityba to dibn 35pt -gt&-; essl mrtou prrssoseu gene rnipintctoasr --&tg; sesl ormut onssseu.rpip

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jcmed atht uowdl eb vlyroe yase of emth thhuog eey llro +

whk123 tsBe xalpeoi.natn +

fhegedus nad ueddsynl ehengrviyt msaek sesne D: hkanT uoy fro a agret aoainep!xtln :) +

+8 upvote downvote
submitted by ∗fenestrated(32)

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Fro ihts neo I intkh ahtw uoy dha ot wkon is hatt tnTrpairsonci N-A;R-gA)&D(Nt si dmrfroeep by NRA yp aems.lroIet saw ont NDA oayserelpm ecebasu tsih one rlitpscaee g(A-N;&D)AtD-N

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fenestrated neebtew crasneedi or areecsdde inginbd I ipcedk edeercsda cseubae it wsa a tuontmia ihchw dfetfcea eht rhdoneyg bnsdo chiwh si how tlceodiensu bidn to hcae thore +1

makinallkindzofgainz isht is hwo I got it irhgt +

+4 upvote downvote
submitted by ∗yotsubato(1208)

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3p5 si teumdat and ntac dinb het TAAT bo,x os hwta npaeshp ot octniatisnprr of hiirybtion pos?ntier

Is absalicly hatw tish tneoiusq si tnrgyi ot .sak..

So on ATTA bxo romtpero t&;g= reedaDesc dibignn fo RAN eplrseyaom

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link981 Yuo isda ,ti teyh are r"gyint" ot ak.s olSdhu seu bteter mramarg. +3

titanesxvi siTh is on srtif d,ai adn sasy that het omprorte rigeno si hwree pNlyaoArseRem disbn +1

nootnootpenguinn uHanka ATT-OAN oxb... hknta oyu ofr tihs laxponan!eti +

+3 upvote downvote
submitted by ∗d_holles(218)

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shTi is a ogdo riptuce of na pmienreetx nwoisgh ht:is

c6c/wpis/1ilusa2e.tntwu.rrt09w/oa/sm1:/fgeh21/ter

cngoneOe ulvemo 2,6 gsepa 2212–1922 0072()

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+3 upvote downvote
submitted by dantescuttlefish(7)

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Wyh is htis ont cdesarnei indginb of ADN s?lmepaorey

ihsT atmiuont hdsolu seuac elrlcual oniidvis ie AND ronptilaice nda uscae nerisdcae bnindgi to igroin piielnoartc uesensqec ei ATTA yb DAN moer.elypsa

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brise 'tIs tanlikg abuot uaitsonmt on teh iapoittscrrnn fo gense ahtt ihbniti eth llce osidin.iv lAos NRA leyrmoapse sbind to hte rtroopme ginore. +

nwinkelmann lo,sA hte uetnqiso accyiieslflp gtuohh( in a ryve row,dy cldovetoun wa)y kedsa what the eecfft of hte inaouttm no aonniptctrisr .aws NAD olp is tno esdu in icrop,tnitsarn it is sued in opcir.naeilt ARN plo is esud in sanpirtt.crion In ersmt fo dscreniea or reeddseac bi,gnnid ngriiang si oiepaorlv/itlsyp dcaehgr dna porieln si nnul,laarenoort/p os rthee ear erfew gnd-nbioH ,essit nda shut ddeerceas dniigbn fo hte RAN .pol +1

medn00b luoCd htsi leudvcntoo eusiqnot asol .a....tm.h .n.t..ae senic the egne to keam 3p5 si msedse pu ued to eht drgnheoy ,sondb ANR lpmaeyoser llwi otn eb aebl ot bdni ot make eth NARm ... oS tereh liwl eb eca?ncr Bceuase 5P3 is a tromu .uerrso.s.psp meeml okwn tkahns ugsy +

+3 upvote downvote
submitted by ∗jessikasanz(9)

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tlo fo wrod mvtio ot sak "ahtw dnbis ot eth ATTA b"ox

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+0 upvote downvote
submitted by pipter(10)

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Dsoe ennayo vhea yan fisiccep aedi no eth naemsimch fo hte 3p5 imtutano sqntuieo inregrdag eht TAAT box the( eno htiw eth slngie mnaoi idca encinosorv dan hte drtefienf ghordeyn gnbn)o?di

I seohc het eaecsdedr dbining fo ANR ermsalpoye no eht ATAT ecenuesq of gnese that biiihnt clel ndoiisvi beasd slyoel on teh ctfa atth 53p is a muotr prsrpessuo aak( eadttum pt&s5gls;e3- biitinnohi fo uvs-&iid;iotnligletpm din)iiosvs.

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joha961 omFr a mdnaor paerp I ndu,fo raA“ylbgu 3’ps5 stom rnotaptim ciftuonn is to atc as a roitsnrapicnt ofrtac thta cdiltrey eleagutrs prsphea eelvsar ddnheru of eht el’cls RAN arlymespeo II (RAPN sIcirn-rIdte)ba enges.” So laolmryn ti sncraesei NAR pol ;nnbdgii a totmnaiu owudl scdaeree .it +1

estsosa eTh TTAA bxo si atpr fo eth mterroop region tesi hrwee ANR plreasomey II dna otehr inostanrticrp froscta dibn to ND.A A detcfe wuold efethroer eescaerd iignnbd of ARN .esplmoerya +7

mnemonia lsAo uoy nca arones it tou (I otg isth wonrg caesebu uyo have ot be ylelar iustlmoc)ue cnesi we nkow atht ossl fo 5p3 = rac.ecn reCcan = tawn roem clle idosvnii = o’ntd ntaw itbinrhyio nege = sels ncrnoptiarsti of iasd egn.e +1

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