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Retired NBME 22 Answers

nbme22/Block 2/Question#35 (reveal difficulty score)
A 45-year-old man with Li-Fraumeni syndrome ...
Decreased binding of RNA polymerase 🔍 / 📺 / 🌳 / 📖
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 +67  upvote downvote
submitted by ∗seagull(1933)
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Did nyeona ndee ot erda hatt tlsa nenctees kile 05 etmsi cebueas eht othura eseusfr to eus tertbe rmr.agam utJs i.unsfrgratt

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link981  hrutoA ilratn:eao "Wtha si gm"aa?rmr +6
qfever  idD aneyno adre ekil 50 simte dan ltisl gte it w?rong (L,LO )em +22
drbravojose  ctAlulay eenrv natruendds hatw the aortuh ygians ta yna t.mei LOL +3
alimd  hucS a hisytt qnstuoie. oD ew llreya have shuc uqsesiton on eth aler a?emx nI my nniiopo teyh jtus hrwto kujn iqostuen to etohs aesesmnsst +1
nootnootpenguinn  hO my o-egndoss tankh u!yo I swa os adm at eorwehv owetr tish ttihys e!qistonu to(G it nwgro l)lo +
xmen  THEY IGEV MOSMTEEI IEWRD UISSNOEQT DRUNIG ETH ALER MEXA D!!N A! IST' XAEEPTREMNLI +


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 +12  upvote downvote
submitted by ∗hello(429)
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The aramgrm fo teh lacuta Q was n.coiugsfn

oT kema rebett ,sseen ti shlduo say c"hWih fo eht woilgnflo is eth msto klelyi lustre no the sarirnicpontt of eegsn ahtt ithinib ellc ndiviosi dan that naintoc eth sncnsoeus cqeeueens .T.A"TA.

,oS teh Q si anksig atubo het p5t3 ngee nad ciyslacplief uboat teh tp53 eeng ermorpto ionegr.

rPootemr ognesir vhea a TATA bxo vosybo(iu,l naemnig rchi ni -TA asbe sp.a)ir -AT aseb iangipr has 2 orndehgy ob,nds wchih skmae tmhe ariese to vlcaee -t&-g; alswol orf DAN tnicptnasroir to ucocr oemr eayis.l ARN Pol deso rsptrcointani of NDA toin ANR.

hTe retein se-tQm aslkt buota how Fiai-unrLme is deu ot a ntauitom ni 53pt egen, iglande ot a lcka fo murto sippsuresno cv.atityi

,So fi het oermtpor rnegio ATAT xbo fo eth pt53 gnee si d,amtuet tenh eth pt35 nege liwl otn teg istercndabr &;g--t sith is ywh theer will be ecdseread ANR loP ndig.bin ANR olP wlli vaeh a cedurde yatbiil ot dnib 3p5t -;t&-g elss rtuom spreusrso geen otpntrnaicirs g&-;-t sles tromu .esupirpossn

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jcmed  htta dwulo be oervyl syea of tmeh hoghtu eye lorl +
whk123  etsB ipeaolntax.n +
fhegedus  nda eudyndls egytevirhn semak esesn :D hTakn yuo rfo a tearg pinlnax!atoe ): +


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 +8  upvote downvote
submitted by ∗fenestrated(32)
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Fro sthi eno I ihnkt atwh yuo dah to wkon is ttha rnocispaintrT tN(-DARg;-)N&A si meferdrpo by NAR It y.seeamlpor aws tno DNA oeaymeplrs ucbeeas hsit one iltacresep &N-AA-N)(;DgtD

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fenestrated  nwteeeb isenaredc or dsaerdcee inidbng I epickd rdseceaed caubsee it swa a iumotatn ichhw efdeafct the nohrydeg sonbd ichhw si how licsetnduoe ndib ot ceha horte +1
makinallkindzofgainz  this is how I tgo it thgir +


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 +4  upvote downvote
submitted by ∗yotsubato(1208)
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p53 is atmtude nda ncat dnbi teh ATAT xob, so tawh epshnap ot riotsracpintn of ihtiniryob opt?nrise

Is asaliclyb twha shti nitouqse is ygitrn ot .k.sa.

So on TATA xob tmrroepo =tg&; Dcraedsee bidgnni of ANR yeprslaome

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link981  Yuo sadi ti, tehy era yin""grt ot .ask Slouhd use tbtree rr.mgaam +3
titanesxvi  Tsih si no first ,adi nad sasy atth eth toermpro giroen is herwe sepaRemryoAlN dnbsi +1
nootnootpenguinn  uHanka N-TATAO b.o.x. aknth uyo for shti nx!pelaniato +


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 +3  upvote downvote
submitted by ∗d_holles(218)
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isTh si a oogd uptcrei fo na nixerepetm ngiwhso i:hst

s2/:s1ui/r9wiatw2l.f6erew/ngoms1tc.ret//thu1c0ap/

egOnceon oelvum ,26 sgpea 2222–1129 07)02(

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 +3  upvote downvote
submitted by dantescuttlefish(7)
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hWy si htsi not edneasicr gindbni fo AND yl?orespema

hTis atnitoum uhdsol ecusa eulalrcl doiinsiv ei ADN ntioleracpi nad escau daerscein iigbnnd to riiong celntiriaop usenqcsee ie AATT by AND elomr.payes

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brise  t'Is inakltg oubat noutmaist no teh aoncitrnrpits of egesn ttha hiitibn eth lcel isdivi.no lAso ANR mpaoyleres insdb to teh eptroomr er.gnio +
nwinkelmann  Asol, het tneqouis pccesliialyf ouh(ght in a vyer oyw,dr odcnvloetu ay)w ksdea hatw eht ectffe fo het niomautt no proarcnstniit ws.a NDA lop is not seud in annsptroii,ctr ti is dsue in etic.opnilar ANR lop is used in nranitortiscp. In rmtes fo eindarsce or rcdseaeed biindn,g rnianggi is t/silrepiypvoola rhgdcea and erilnop is larnlurt/,oapnneo os eethr era eefwr inb-dHnog ,itses adn htus credadees inndgbi fo eth NAR o.pl +1
medn00b  odClu tish ndluvoceot sqoitenu lsoa h....ea ..nt.t.m.a. sceni teh ngee ot kmea 5p3 is sedems pu deu ot the geyhdnor nsbd,o ARN erseamlpyo lilw ton be ebla to bind ot ekam het NRAm ... So ehetr ilwl be en?arcc caBeseu P53 is a turmo .pser.pssruo. mmeel ownk thsank usyg +


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 +3  upvote downvote
submitted by ∗jessikasanz(9)
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lto fo rwod vmtio ot ksa at"wh dsinb to teh ATAT xob"

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 +0  upvote downvote
submitted by pipter(10)
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Dseo oyenan vaeh any csiipcfe aeid no teh hemacsmni fo hte p35 tmtounai oiqnesut naerigrdg eth TAAT xob h(et neo hwti hte sglein inmao cdia ninovrseco nda het defitfren enyhgord ?ibn)ngod

I chose hte deadcrsee dgniinb of RNA opyrlmesae no the ATTA eeqecsnu of egnse tath tiihnbi llce ndiviosi badse sloley no teh fcat hatt 53p is a tomru rpuoerpsss a(ak autmetd t&-35s;lpegs oniinbiiht of uisnoge-vdlt&mipi;itl i.vioid)sns

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joha961  Fmor a droman rpape I n,fuod albAygur“ sp5’3 msto pitntoarm inofuntc si ot tca as a stprnrtcnoiia artcfo hatt clyditer ulergtaes papehrs easvlre uddehnr fo hte scl’le RAN lrspeeomay II RNP(A a)srn-IidItrebc s”egen. oS yllrmano it enariessc RNA lpo digibn;n a totnimau udlwo eredcase .ti +1
estsosa  Teh TTAA bxo is atrp fo teh romptoer norgei stie hwere NRA seayplomre II nad rothe roinatscintpr tcsfaor bind to DA.N A edfetc uolwd hrfteeeor aedrsece inidgnb fo ANR p.areosemyl +7
mnemonia  sAlo yuo nca asnoer ti tuo (I gto sthi rngow saeuceb uoy vhea ot be leyalr limots)cueu escin ew nkow taht sslo of 53p = cnc.rea ecaCrn = twna omre lecl idnvoiis = tnod’ twan rhytinbioi gnee = sels nnarrcititosp fo sdai .ngee +1


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