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Retired NBME 22 Answers

nbme22/Block 2/Question#35 (reveal difficulty score)
A 45-year-old man with Li-Fraumeni syndrome ...
Decreased binding of RNA polymerase 🔍 / 📺 / 🌳 / 📖
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 +67  upvote downvote
submitted by seagull(1933)
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diD eoynna need ot aerd taht ltsa esetencn leik 50 emtis scebuae eth truaoh ressfue to esu tebter mraag.mr ustJ gstiarrtufn.

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link981  ohAtru aatieon:rl "tWah si m?a"rragm +6
qfever  idD nnoeya rdae ielk 50 miets dna illst gte ti gr?onw L(L,O )em +22
drbravojose  ctalAuyl ernev udatdernns hwat hte tuorah nsgaiy at nay emti. LOL +3
alimd  chuS a httysi u.entisoq Do we eallyr heav hscu inusosqet no het alre ema?x In ym iioponn yteh tusj owrth nukj nqeiutos ot tshoe ssematnsse +1
nootnootpenguinn  hO my dsgono-se hntka yu!o I was os amd ta oerwvhe tewro tshi httsyi n!utiosqe to(G ti onrgw oll) +
xmen  YHET GIVE MSMIEOTE RIWED SUNIOQSTE UDRING HTE LARE EMAX ! !!NAD 'IST AEPNRTEMLXIE +


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 +12  upvote downvote
submitted by hello(429)
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eTh gmaarmr of hte ulaact Q asw fsun.ognci

To mkae ebtret es,ens it ohldus sya iW"chh fo teh giwnolfol si hte tmos iylkel uestrl on eht rtinnitospcra fo senge atht nhitibi lcel idioivns nda htta itnncao the ncsesousn eneeqeucs ."ATA.T.

o,S eth Q is ingaks atobu hte t5p3 eneg and ciyepllacfis obuta eht p53t egen emroport negior.

rPtoreom nrisgoe veha a TTAA oxb osu,oi(lvby niamgne hrci in -TA aebs aris.p) -TA aebs grniipa sah 2 enodyrhg n,bosd hiwch maske etmh airsee to ecelav gt-&;- wolsla fro AND rtiritocapnsn to ucorc oerm eyia.ls NRA olP oesd rtiptcanirsno fo NAD noti .NRA

heT inreet e-Qmts kstla taoub how amu-nFeiirL si edu to a tounamti in t35p nee,g neidlag to a lakc fo outmr iposesusrpn tyv.iaitc

,So if hte terpormo ernogi TAAT box of the 35tp neeg is utdemta, tenh eth 3pt5 eegn lliw not etg idrcbarstne &-;t-g itsh is hwy reeht llwi be eeascerdd RNA Pol di.ginnb RNA loP illw evha a uceerdd atbylii to indb 5tp3 ;--g&t less rutmo rpusrseso neeg cianptisontrr -;g&-t sels urmto uipnero.sssp

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jcmed  atht doluw be yvlero yase of tmhe othguh eye roll +
whk123  Btes xiapnltnaoe. +
fhegedus  dna dnelsudy grhnyeievt mesak nsese D: kaThn uyo fro a agetr einlon!axpta ): +


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 +8  upvote downvote
submitted by fenestrated(32)
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For htis neo I kihnt twah yuo dah ot wnok si thta rnirnsicTapot tADAN&--RgN(); is eormpefdr yb NAR al.pIy temosre aws otn NDA peemosraly sabeuec isht noe raetcsplei -D;tN)-&(DNAgA

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fenestrated  wenbeet decirsean or deerscdea nbngiid I pdiekc ddecaseer csaeeub ti asw a imoutnat chhiw dtacfefe eth ergdnhyo sbnod hwcih is how clndeiuotse inbd to aceh tehor +1
makinallkindzofgainz  itsh is woh I tgo ti ighrt +


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 +4  upvote downvote
submitted by yotsubato(1208)
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p53 si tmdatue and tnac nbid the ATTA ox,b so wtah nphpeas ot nrcnapiroitst of horiybiint onsptier?

Is aclbyslia hwat isth tuiqsnoe si ginyrt to s.k..a

So on AATT box mporeort =t;g& Ddceaesre bindgni of ANR eserampylo

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link981  uoY adis it, yhet are gi"tr"yn to aks. udhSol esu tebter rrm.agam +3
titanesxvi  Tish is on sfirt d,ia nda says that teh tpemorro nigeor is ewreh RolrsepNemAay sbind +1
nootnootpenguinn  akaHun NATTAO- .x.o.b nahtk uoy rfo stih ilpx!ntneoaa +


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 +3  upvote downvote
submitted by d_holles(218)
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shiT si a oodg uitcerp of an ipenrexetm gwhsino sti:h

t2.1/wi2ltc.rtt61/manerh/0/c9e/eos:suigwwsrufa1p/

coneengO emuvlo 6,2 seagp –21222192 00)7(2

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 +3  upvote downvote
submitted by dantescuttlefish(7)
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Wyh si hsit tno eresdcnia bgindin of DAN yom?psearel

ihTs ttuinamo dlohus esauc laecurll visiiond ei NAD catirnpieol and cause icnesadre dinbgni ot inoirg lnieropiatc eeuesqscn ei AATT yb DNA ospeymarel.

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brise  sIt' knagtil botua osmntuait no eth cinatrisrtnop of neges atht tihinbi eht ellc i.soidivn osAl NAR mslaeroyep bnsid ot teh ooemrtrp igo.ern +
nwinkelmann  Alos, eth qseuiton ifaceliyscpl hghout( ni a yrev w,yord lcvoenduot )ayw akdes hwat hte tcffee fo eht amtonuit no soirtpincnrat .saw NDA olp si tno seud in prntrson,iitca ti si udes in lpantceioi.r NAR pol is sdue in ritrnaipctons. In emstr fo darecesni ro ecedrades gbnnd,ii ginaginr is p/riovastepiylol dagehrc dan inoerpl si olp/ar,oelnranutn os rhete ear ewref inHnod-gb t,ises adn tshu dcdereesa ndbniig fo eht ANR o.lp +1
medn00b  udlCo ihst tuevnoodlc ueontsqi lsoa .anth..ta e.....m.. ecisn hte ngee to kaem 53p si smsede pu deu ot the oryedngh on,dsb ARN oysleremap wlli not be bela to bdni ot amke het ARNm ... So htere lwli be ?naeccr asBeeuc 53P si a outmr oerp.s.s.uprs emlem wonk hsntka suyg +


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 +3  upvote downvote
submitted by jessikasanz(9)
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olt of dwro itmvo ot aks wa"ht nsibd ot het ATAT "box

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 +0  upvote downvote
submitted by pipter(10)
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oDes eyaonn ahev nay cpefiics iaed no the ahinscmme of het 3p5 ioautmtn qoinuste ngigrreda the AATT xbo (the eon hwit the lsneig oaimn idac ioesnorcvn dna teh iedtnffre hydegnor ?gido)bnn

I escho eht escardeed iidnnbg fo RNA releosamyp on the AATT eueqnesc fo nsege that btiniih ecll dinisivo asbde olleys on eht tacf taht 35p si a uotmr sprsrpuseo (aka admtteu 3lgtses-&;5p itonnibiih fo &nu-t;lmpiigivtlosedi ids)oivins.

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joha961  mroF a daormn preap I fnu,do gyaul“rbA p’3s5 toms npmiortta utnicofn si to tca as a ranpsiotnrtic rafcot tath tdliyecr glsueetra rhspeap sevlera hdenurd fo eth el’slc NAR elrseaypom II NRP(A tr-)bidceInIars gen”.es oS lmnroyal it seaeisncr NRA lop i;bgindn a ttaumoin wlduo eecrasde .it +1
estsosa  ehT ATTA box is aptr fo eth rotoerpm gerion iset ehwre ARN erysalpoem II and otrhe crrottnipsnia rotsfac bdin ot DA.N A etcfed ouldw tofeerehr saceeerd gibdnni fo NRA .raepyemslo +7
mnemonia  olAs yuo nca seonra ti uot (I got sith gnrwo useeabc you hvea to be arelly esuo)cutiml sneci ew nokw ttha ossl fo 35p = acnr.ec cnrCae = twan meor lcel iiiosndv = o’tdn natw hironbitiy geen = lsse irtrscnitnpao of siad .geen +1


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