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NBME 22 Answers

nbme22/Block 2/Question#35 (57.5 difficulty score)
A 45-year-old man with Li-Fraumeni syndrome ...
Decreased binding of RNA polymerase🔍
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 +57 
submitted by seagull(1389),
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dDi onenya eedn ot erad that lsat nnctseee ikle 50 etmis eausecb eth tarohu fueessr to esu ebtret .rmrmaga Jtus trsf.nratgui

link981  Author rationale: "What is grammar?" +6  
qfever  Did anyone read like 50 times and still get it wrong? (LOL, me) +16  
drbravojose  Actually never understand what the author saying at any time. LOL +3  
alimd  Such a shitty question. Do we really have such questions on the real exam? In my opinion they just throw junk question to those assesments +  
nootnootpenguinn  Oh my goodness- thank you! I was so mad at whoever wrote this shitty question! (Got it wrong lol) +  



 +6 
submitted by fenestrated(27),
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roF hsit eno I kthin htaw uoy hda to know si atht nTaistrcpionr (NA)DR--&A;tgN si merfedrop yb ARN t.a eyoIemsplr saw nto NAD ysarlmeope cebseua hist oen tailsecerp NN(AA-&;t)g-DD

fenestrated  between increased or decreased binding I picked decreased because it was a mutation which affected the hydrogen bonds which is how nucleotides bind to each other +1  
makinallkindzofgainz  this is how I got it right +  



 +6 
submitted by hello(298),
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Teh rrmmaga fo het tuacal Q saw .sngioucnf

To keam tbteer ss,ene ti sduhol ays hh"Wic of the filwlongo si eht tmos ilyelk turlse no hte onttirnpsrcai fo gnsee hatt ibhtnii lcle osinviid nad thta otciann eth unsssnoec cueeneesq AT"TA...

S,o het Q is ingkas toaub het p35t egen nda asfieilycplc abtou the p53t egne rpomtero einrog.

Ptrroome seniorg vhae a ATAT xob ibl(,usovyo ameinng ihcr ni -AT aebs rs.pi)a -TA sbae pairgni ahs 2 ydonerhg sdb,no hwhic ekmsa tmeh aresei ot elvace -&g-t; lwlsoa rfo NDA anoitsctiprrn to rocuc mreo se.lyia NAR lPo eosd tstanpincorir fo NDA iton RNA.

heT ietrne tQs-me lakst botau how uFireinam-L si due ot a untmaiot in 35tp ,eeng igenlda ot a lakc of oumtr nsspusoreip atvyi.tci

S,o fi eht merropto engori TTAA obx fo hte t5p3 neeg is dutma,et htne eht 35pt egen wlli not teg raisrntcdeb -gt&-; stih is ywh rthee ilwl be eddserace NRA loP innidbg. RNA lPo lilw ehva a rdcedue btalyii ot nibd p3t5 -&;gt- sesl uotrm rsspouesr eeng onstaicnrpitr g-&-t; sles ourmt .ppsnesrsuoi

jcmed  that would be overly easy of them though eye roll +  



 +4 
submitted by yotsubato(961),
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53p is umttdae adn ctna indb het TATA ,xbo so wtha npesahp ot rnrtiscpnitoa fo oybritinih tsnoierp?

Is labacsyli wtah tihs ioqstnue is gntiry ot s..ak.

oS on TAAT obx mreooptr =t&g; saeecedDr gnibndi of NAR posemlraye

link981  You said it, they are "trying" to ask. Should use better grammar. +3  
titanesxvi  This is on first aid, and says that the promoter region is where RNApolymerase binds +  
nootnootpenguinn  Hakuna NO-TATA box... thank you for this explanation! +  



 +3 
submitted by d_holles(170),
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sTih is a odog uteiprc of an neretixmep nwgoish shi:t

clnre9siecoss/hf/1/twr/1ut0m:2r/atwap.62/t.1guiwe

eegoOcnn umolev 62, sgape 2229–1221 0)7(02




 +2 
submitted by jessikasanz(4),

lot of word vomit to ask "what binds to the TATA box"




 +1 
submitted by dantescuttlefish(4),
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yWh is iths otn dsiaecenr dbgniin fo DNA peolrymeas?

hsiT oamtunti husold secua lucarlle isviniod ei DAN lpincreiato nad asuec eiadcersn gnnidbi to igirno iinalpectro eesensucq ie ATAT yb DAN eoems.lapyr

brise  It's talking about mutations on the transcription of genes that inhibit the cell division. Also RNA polymerase binds to the promoter region. +  
nwinkelmann  Also, the question specifically (though in a very wordy, convoluted way) asked what the effect of the mutation on transcription was. DNA pol is not used in transcription, it is used in replication. RNA pol is used in transcription. In terms of increased or decreased binding, argining is polar/positively charged and proline is neutral/nonpolar, so there are fewer H-bonding sites, and thus decreased binding of the RNA pol. +1  
medn00b  Could this convoluted question also mean.......... that since the gene to make p53 is messed up due to the hydrogen bonds, RNA polymerase will not be able to bind to make the mRNA ... So there will be cancer? Because P53 is a tumor suppressor... lemme know thanks guys +  



 +0 
submitted by pipter(9),
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sDeo ennayo ahve nay epiicsfc aied no eth minehcmsa of eth p35 mtatuoin quoesnit geirragnd teh AATT bxo th(e eon with hte sigeln moian iacd nnscovreoi adn teh nieffredt eoghynrd no?g)nbid

I scoeh the daecesrde iignnbd of ARN roeaemplsy no hte TTAA ueeencqs of seeng that ntiibih cell nsidoivi adebs lysoel no teh fact ttah 3p5 is a omrut popsressur kaa( emutdta e3p&g-5sstl; iihtbinion of tdpg;ii&vuel-inoslmit iid.sos)vni

joha961  From a random paper I found, “Arguably p53’s most important function is to act as a transcription factor that directly regulates perhaps several hundred of the cell’s RNA polymerase II (RNAP II)-transcribed genes.” So normally it increases RNA pol binding; a mutation would decrease it. +1  
estsosa  The TATA box is part of the promoter region site where RNA polymerase II and other transcription factors bind to DNA. A defect would therefore decrease binding of RNA polymerase. +6  
mnemonia  Also you can reason it out (I got this wrong because you have to be really meticulous) since we know that loss of p53 = cancer. Cancer = want more cell division = don’t want inhibitory gene = less transcription of said gene. +1