I htkin omer ,lnlegyear etnpiro igofnld shppane at the RER dna het emst assy het nrtopie ’dnoest fold rrppyole. aipllfc,yeicS hte sotm comonm CF auinttmo is a sfddlioem tnoripe adn the orepint si eaderitn in teh RER dan ton drrstpontae to the lcle bmneamer - FA 9102 gp 6.0

Teh TRFC reiotpn si a nbramesentarm itn.poer kieL lla ireoptn,s tsi aninrlottas bngsei in eth sol;toyc htat sd,ai RTCF nscanoit an suen-itrmN anlgi“s ee”eucq,ns hhiwc asnem sa it si bneig dt,anaetlrs it n(da eht oimebosr inkmag i)t! lwli eb dtoernsprat to teh mpsocdlniEa lmueRit^.uceftotono!

sA it steg rneasltd,at tsi ihhbrpdoyoc oimfst liwl g,ereme chhiw bsdeem teh CFRT optrein tihnwi het iodilhspphop ableyri of the RE l!eifts Ttah eamsn eht noeiprt lwli vrene gaina be nduof ni“ eht ”sltooyc eeaucsb ti esgt dadteerh gtourhh het yealrib ihhcw( si, ni t,afc hwo lla nerrnbeamasmt tsroniep eboecm emmrbnanraest inoerpts at the llec afreusc -- tyeh vhea ot eb dame tnoi nastrmmnrbeae rtnpeiso in teh ER stf)r.i!

o,S ,yse ,tlaiymeutl seeht fdmslideo noriptes llwi be trddicee odwtar a opmsoerate rof gileagrcina/nrotddye,c utb hatt illw paphne sa a tleitl eeisvlc ro( mis“”)el;oop eht mflosddei pniero,t in siht cas,e is not aswrleel-obtu e,(csin yb idiftenino, ti sah dbihopohcyr mfotsi ihhcw teg hdereadt“ grhth”ou a raleiyb ot etaerc hte rnmmnaesbaert nt)are,tp chwih menas uyo tw’on fidn it ni the yolocst.

\ !fnootoet \ The iicgthhn of e*iacvt somebsior ot teh linapmsEocd iuuemtcRl is ywh we clal atth aaer of ER hg“rou siopndlEamc eultmuRic ”(Rr;E) no eeolrnct ,simcporoyc hatt enstoci aws ebepslekcd hitw ettlli odst; aelr,t ew sahu)(mn evdoeidrsc tath shtee odst erew !ssbmoireo

\ * \ By veatci“ eobmosis,”r I tjus mnea bomieorss in the scsoper fo ngovcirent mNAR to on!retip tWa(h ew call ”lstnrtianoa“ );

For a etagr llitet masruym of eht moadlpEscin Rtumuceli (adn aynm eotrh cnotepcs ni cuaerollm libo,oy)g! see shti mfro r’stebAl lrMuoceal oogBliy of eht Cell:
n8s:ok.h/inpwK/hi4.b2v/ng.mt/wc42wBbN/.26lo0Ao#1ts

When stirepon begin mdae ni het ER idflm,so htye lmcecutaua ni teh ,ER wchih etnh retgsigr meht ot be tsip out otni hte ctsyool dan mbeoec ddaeedgr yb espmeot.rsao T,hsu het ctamcolnaiuu of eth iedfdslmo orptnie in hte RE is qduierer for htem to aeiymultlt be gtadge yb biiutqniu and be eagrddde in rmes.oeptaso

enEv fi you rgeau atth eyth lliw eb cagcmualntui in teh olycsot cabeues tooaempsres aer in eht ,ytocsol eht qontsiue si ngsaki where rea the stporine acluunmtigac, ton enbig dgrdedae. So hety ntca' acaumeutcl ni pm,oesrtaseo esceabu hety rae etdsyorde in tmhe.

iTsh si mfor soasmb: tdtMaue CTFR enge (5Δ8F0 mt)auinot → dlsdmifoe eiptnro → iefeevdtc toienrp is eetdrani ni the guroh sceplnamoid tulemuirc )r(ER for eatgaodindr → TtPd-eaAg drioelch calhenn is tensab no eth ecll fraceus fo ileahtelpi llcse turohhutog eth body ..,(ge nttlnieais nda irytrroaspe paielhtei, wetas gl,asdn ixoeernc ,aacprnes eexoncri naglds fo uodevirpecrt sngo)ra

AUTLR PMSILE.

.erh1te aer yanm naraisvt of ictcsy iifosbsr os sthi tnqousei si not tuabo .hyyspthap fo CF

tnpio.2 fo qonutsie : werhe dose itepnor ionfgld ouccr ? e)awsrn RRE

1. NI HSIT PETY FO FC , fi otnrpie nisot fdlode prleyrpo ni RER will it go uot ro ilwl ti eaaulctmcu ? asewnr) it ilwl autclemcau ni ER.R

TIP : IF OYU EPEK ANGEIRHCRES ON SIARVATN FO ,FC OUY ERA ON A APTH TO NDESSEL OOMD