I hinkt erom rl,geeynal retipno indfglo saepphn ta hte ERR dna teh mtes sasy het eiprotn s’tdeno ldfo plryep.or ayeiScp,flcil eth most ncmoom FC totnaumi si a fmiedsdol ertinop and hte trinpoe is deainter ni the RRE nad not osaprtdretn to eth lecl embarmen - FA 0219 gp 0.6

The FCTR nerotip is a rrntanmebaems .tnreoip ikeL lal roespit,n sit ilarntsatno esnigb ni the y;loosct hatt das,i TRCF cnitsnao na mtsruN-nei nisa“gl qence,”seu hwich eamns sa ti si begni dlrtea,satn it and( the boosirme gnikma i!t) ilwl eb ronetasrptd to the acsimdolnpE Ruiltmuec.^oto!ntofe

sA it steg aratden,tls ist bcdhyrohpio smotif lliw eer,egm ihchw smdbee het CTRF rtoinpe iwhtni het oshpiihdpolp alybeir of hte RE sef!lti tTah naesm eth ntreiop wlil renve aiagn eb fundo n“i hte so”olytc acsueeb ti gest detaedrh rguhhto hte iylraeb ci(hhw i,s in ca,ft who all beammtnraesnr poneistr coebem erermmanbasnt oistnerp ta eht clel urcsfae -- yeht veha ot eb eamd into mnbesreatrnam opisentr ni hte RE f!r)st.i

S,o s,ye myaue,tllit sehte sdomdlfie etopirns will eb etedridc rdowat a oereaomspt rfo /cd,cgrrntnedialaoeygi tbu thta wlil ahnpep sa a tlltei veliesc or( s)e“”oio;mpl eth loddsefmi ntie,pro ni shit csae, is nto elsewrutoa-lb nc(ies, by dti,ioenfin ti has hhciproydob omisft chwhi teg tdeea“hdr hugrh”ot a yaeribl ot eterac eth rameanmnbetrs tert),npa hchwi asmne uoy tno’w ndfi it ni eth .oscoytl

\ !ttofonoe \ Teh cithgihn fo cavie*t sisbeoomr ot eht lmEoniaspcd ticReumlu si why we llca hatt eara of ER groh“u pEocilnsdam cieuRumtl RE;(”r) no lronceet ocrsyp,mcio ahtt neiotsc swa plesckbeed ihwt ttliel o;std rl,tea we ns(aumh) cevsreddoi thta sthee otds were somsobire!

\ * \ yB eic“avt sobmi,re”os I utsj neam mobeosisr ni the sescpro of geocnvnrti mNRA to nreiop!t t(hWa ew clal ”taliao“nsnrt ;)

roF a arget litelt muysamr of teh amplicoEdns teRlimucu dn(a amny otreh eocsnptc in lrceuamlo gly!i)o,bo ees sthi mofr ’lsAertb lroecauMl Blogoyi of hte lelC:
8k4/w2ssn2n/2/4nAhh:o.tm0v..6wpii#ltc.wgoB/bKNb1/o

hneW ionterps ebgni emad in het ER islo,dfm ythe atlcucemua ni eht ER, chiwh neht rtiegrsg ethm to be pist otu onti eth olsytoc nda boecem drgeddea by oostmaersep. hsTu, hte ilumatnucaoc fo teh fsdmdieol nproeit ni the ER si ereirqud for mhet to tlaleytmiu be gtgade by tuuqibiin nad be dergddea in e.optearssmo

Evne if ouy ageur thta eyht wlli eb tunamaclucig ni eht lysootc sbaeceu aosoptseerm rea in hte c,olysot eht neiutqso si saingk hwree aer het repnstio ualtugicnmac, nto genbi regddeda. So tyeh 'tacn ctcuemulaa ni asrotpmesoe, eeuascb ehyt rae eyodetsdr in htme.

hsTi si frmo :abmsso ueatdMt FRCT gene 8Δ(F50 iao)untmt → iedlsmfod npiorte → vctieedef npioetr si nrtaedie in eth oguhr sionpeclmad cerilumut r)R(E for dtoandeairg → -APTgatde ilrdheoc clnahen is besnta no eth llce faucers fo leplthieia lscle otuohurhgt eht bydo .e(g., itnneitsal nda asoryperrti hiaptee,li tswea dnlg,as ceeoxirn pnraas,ec coxreine dagsnl of iceerdrptuov ang)sro

ARTLU ILME.SP

h.re1te rae yman aivtsnra fo scciyt obssiifr so shti teuqnois si ont oubat phyyahts.p fo CF

2oi.pnt of sineoqut : wereh dsoe rinptoe lingfod rcocu ? we)nrsa RER

1. IN ITHS PTYE FO FC , fi petorni oints fodled eporlyrp ni ERR ilwl it go tuo or llwi ti aealmutcuc ? r)wnesa ti will lccmuauaet in RER.

PIT : IF UOY KPEE GERECIHRANS ON AVAINTRS OF CF, YOU ERA NO A PTAH TO SSLDNEE DMOO