For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204
I haev an iessu tihw sthi uesqnito cwhhi osla tcilsocfn thiw .oUlrdW nI eordr to eb dagedder by tmosseoerop the sdmeloifd oreitpn doluw ende ot be eerstnp ni het clstooy rof ituboun.ain It it uluatcadmce ni teh RER ehtn who dsoe it get ggt?dae o,ntylseH so o.cincd.eltf.
The CRTF notrepi is a ernsemmraantb onertpi. ieLk lal s,rnioept its altroisantn inbegs in hte olsyco;t that ,dais FTRC coinatsn an nmuit-srNe lsi“ang ucee”qe,ns ihhwc mensa as ti is bgein natretlas,d it ad(n eht oiebmsor igmnak !)ti illw eb nteprodtsra ot het pnadEocmisl tumeu.Ri^lcooenft!ot
As ti gste adneslta,rt sit bdoiohyrhcp omtfis illw rgeem,e hiwch seemdb teh CRFT rnoeipt inihwt the lspdophhoipi aylibre fo hte RE tfiesl! tTha eanms teh prteino wlil vneer gaina eb odunf n“i hte ”olytocs eusaebc it stge eehadtrd urhohtg hte lbyaire wcih(h i,s ni ,fcta hwo all neamsrnatbrem inseropt mecbeo embantarmrnse tsenipro at het elcl escuafr -- yeth hvea to eb adem tnio raebamrmsnnte tprsoine in teh RE )tsi.!rf
So, ,eys uttlyal,eim eseht dmseofldi nreptois llwi eb eceidtdr atrowd a torsmeepoa rof nayi,cdtregg/rinealcod tub ttah will hppena as a ltelit veselic o(r ;lpi”e“oso)m eht edsofdiml enirt,op in htis aecs, is tno rlwtel-baueso cin,se( by ion,nfetidi it ahs coobrhyidhp mofsti cwhih etg h“rdedtae oh”htrgu a breiyal to aceert teh mareaermbntsn )ernta,pt icwhh amnse oyu nwto’ fdin it in teh oocly.ts
\ onooeft!t \ Teh chnthigi of vc*eiat omosbesir to the ncalmdiospE telRuicmu si hyw we allc hatt area fo RE g“uroh osEilmpndac mRcliuuet E()”rR; on eetnclor mopycsir,co ahtt ineotsc saw edkceeplbs htwi iletlt sdto; r,leat we (ausnh)m dceisodevr htta teshe tods eerw oseob!smir
\ * \ By i“evcat ”rombsoise, I tjus aenm oimsoebsr ni het eprcoss of evinntogrc RmAN ot tn!oriep a(tWh ew acll st“taao”nriln );
For a aretg eltlti armysmu fo teh pcomlsnEida itumuelRc dan( namy toher teoscnpc in urlleoacm ,)bgl!yoio ees this morf sl’Abetr alcouelrM lByogoi fo eth lelC:
82ist41p2k./h./bwg.NB/l6hotmwsn/o/#2w4v0bnA:iKc.on
A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257
ehWn pntsrioe iegbn dema ni the RE losdifm, etyh mcaalcuetu ni eht RE, wcihh enth rsgeitrg them to be psit tuo toin het ooscytl adn obcmee egdredad by step.eoamrso suhT, the anumucotclia fo eht isldfeodm rpieotn ni eth RE is dqrerieu fro hmte ot lamtytleui eb taeggd yb ibnqitiuu and eb aegedrdd ni srapet.omoes
Even fi uyo guear atht eyth iwll eb gtcuncaiulam ni hte otcosly bceeuas saeropseomt ear ni the lcstooy, hte ueqitson is ganksi ehrwe are eht itseonrp gmtiaccunual, not iengb ddeaderg. oS teyh tac'n ulacmtcaue ni ser,meosptao abecesu eyth are drytdesoe ni em.ht
Tish si rfom oms:sab adtutMe FRTC nege Δ(0F85 ttmno)uai → oemflddsi ioetrpn → deifcvtee tneropi is naeedtri in het uhrgo pomiaclsnde uetmuicrl r(E)R fro dgardniteoa → tTPgae-dA hlrcoeid aclhenn is atsben on hte lcel rfuesac of leilaehitp cells ttgohrouhu the ydob g,.e.( naetsinlit adn ryseiatprro eihp,litae ewtsa ndaslg, ceieoxnr a,snraepc neericox lngsda fo oripdteecvru rgo)asn
URLTA .EMSLIP
e.t1her rea aymn aarsinvt fo tiyccs ribossfi os sith sneiuoqt si ont atobu typhay.psh fo CF
t2pi.on fo untsqeoi : eehrw dsoe eptrino lfdinog ruocc ? )wnrase ERR
TIP : IF YOU KPEE GHRCAENERSI ON NARAISVT OF ,CF OUY RAE NO A APHT TO SELNESD ODOM
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$379$49I ihtnk remo rlee,galny etponri dfgonli pehnpas ta teh ERR adn het stme yssa hte oeprnti tsndeo’ lodf peo.lpyrr Sliyfccpeia,l eht sotm moncom CF mntoiatu is a solefimdd nproiet dna eht inptreo is rneieadt in teh RRE nda ton rnatrsdpote ot eht lcel rnbmaeem - FA 0912 pg 06.
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