For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204
I heav na siuse ihtw htsi usqtoein hwchi oals fiotclncs wthi Udo.rlW In reodr to eb ddeaedrg by moopoesesrt the dlidfmeso ronpeit ludow eend to be eentsrp in eht tsyoclo rfo .ntouabiiun It it tcucaueadlm ni teh ERR nteh who esod ti etg getgd?a ytloenH,s os ti.nfc.ocl.ed
heT FTRC prineot si a marnnsaebmret pinreot. kiLe lla ,etsipnro ist tnlaotrsain gneibs in the ooslt;yc atht dai,s CFRT icnsaotn an uts-rneimN gsia“ln ,en”uqcsee hhiwc mesan sa it si egbni l,teasdantr ti da(n eth irmosobe kimagn ti)! wlil eb danopresrtt ot the Emdispnlcao R^lu.miutecoeofn!ott
sA ti steg atrtsaenl,d sit cdpbhiorhoy oismft wlli eeremg, cwhih ebdmes eth FTRC nirotep tiiwnh hte ldpihpphoios rbiayel fo het RE s!etlif Thta emans het nportei iwll vener nigaa be dnfuo “ni eth lsocoyt” escebau ti etsg etrhddae guhohtr the ayrebli h(cwhi i,s ni ctf,a ohw all bmnesrramtaen iprsoetn mcoebe mtrsraebnanem pseoirnt ta eth clel cufsaer -- eyth ahve ot be amde inot nbmenamstaerr ietrnspo in the RE i)!frt.s
,So sey, utalmitl,ye tehes fdioesdlm nisrtepo lwil eb dctriede adrotw a esomraetpo for ,ndneaateocrdigr/ilycg tub that illw nhappe sa a ttliel isceelv or( o;“s)ipl”moe eth emifldods ripteo,n in sthi a,ces si otn -brauetlwelso eicns(, by dnoiiitfen, it ash oriyhodbpch motfis cwihh get ehde“dtar ”grohhut a airebyl ot arteec teh anrbaemenstrm )aprn,tet hwchi smena uoy wto’n dinf it ni teh otl.yocs
\ oon!tofte \ heT hihgtinc fo iaecvt* sosermboi to eth oEldsmicapn eiuumltRc si wyh ew clla atth eraa fo RE r“ohug pEmlodaicns tueiucRlm E”;(R)r on enrctleo mpriccsoo,y tath tnesoci asw eskbeelcdp whti ltilet ds;to aetr,l ew m)(sanhu cidesvrode ahtt tehse osdt ewre risoemobs!
\ * \ yB vci“tea oeisrombs”, I sutj neam rioobsems in hte porsces of nnrvtoegic RNmA ot !eripnot Wth(a we alcl at”tnais“lnro );
Fro a eagrt ltteil srmamyu fo hte pdoilmaEscn etcluuRim d(na anym htreo sncocpet ni mlluocera ,!goi)bloy ees stih mfro lsrbA’et ueocalrMl glyooBi fo teh Cell:
#6vihtin0w:/4mw/t/./2/nwNbnb.8..ssh14KoBgp2A2cookl
A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257
nWhe nietrspo geibn aemd ni eht RE d,lifsom thye alcuuamtce in the ,RE hwich tenh rtgrgsei tmhe ot be sipt otu tnio the ocostly nda eomecb ddeeragd yb s.oroeatemps shuT, eht uouitalcmcan fo het dloedsimf opeinrt ni teh ER is rreeuidq for mteh ot miettually eb gdtaeg by iibnuquti and eb gdaeeddr in rp.aosetemos
nEve fi uyo graeu thta yteh illw eb aaglccitunmu in teh syoclto subeeca eptemssoaro ear in hte ty,csloo the eisnutqo is ngiask wheer are eth tireposn mncaciuuaglt, tno geibn gddeader. oS yeht acnt' tumacaceul in etprsamos,eo ebasceu ehty ear yeosdterd ni t.meh
sihT si omrf :oasbsm Mtdetau TCFR eeng (0Δ8F5 ao)mtiunt → mieosfdld teoprin → edvtceief iotpnre si eerdnita ni the hgruo sdpnleomaci riuctmuel ()REr ofr intaredagdo → -gtePdATa ohleicdr clnaehn si enabts on teh elcl uasercf of ihtailepel lcels ouourgtthh eth odyb .g(e., enttalinsi dna toeyrpirsra apee,ilthi etswa naglds, ocienerx ncepa,rsa erxcoeni lndgsa fo udcvtrprieeo n)osrga
LTRUA PLEM.IS
.thre1e ear myna nivsaart fo siyctc sibsfori so sith inteuosq si tno abotu phpayyt.hs fo CF
nt.o2ip of unoiqtes : wheer sdoe eptroni godilnf orccu ? ern)asw RER
TIP : FI UYO EKEP HGAREINESRC NO ARNTASVI FO FC, YUO AER ON A THPA TO NLSDESE DOMO
fuh lleptw3g.nej=?cpi_aa;Hsp//hb&cNatoQBmhoyfasiwmntwoayu=unsI.lyhtvcGguoe/lXbe:w
submitted by ∗vshummy(184)
It can be re-accessed by making a purchase.
Purchase your membership here
$379$49I hintk orem aellreyn,g erptnio difgnol epnapsh ta hte ERR nda eht smet says the rointpe td’nose lfod le.prpyor pilleaciSfc,y teh stmo mocmno FC mtoaiunt is a fmdoiedsl oipetrn nda eht eptiorn si ateidren ni hte ERR dna not atpetsdnorr ot eth ellc emabmnre - AF 1209 gp 0.6
$379$49