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Retired NBME 24 Answers

nbme24/Block 3/Question#46 (reveal difficulty score)
A 15-year-old girl with cystic fibrosis has a ...
Endoplasmic reticulum 🔍 / 📺 / 🌳 / 📖
tags: cell_bio cell_transport cell_trafficking protein_folding

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submitted by vshummy(184)
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I nitkh reom ene,grlayl noptrie lgodfni nhepspa ta het RER dan hte emst ayss het nptoire tndeo’s dflo plyrpore. iefl,ipalyScc hte tsom mnocmo CF maoitutn si a fidsdmole toenpri dan het prtoein si tedainre ni the RRE nda not oanrsttedpr to eht lcel embmnare - AF 9210 pg .60

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uroosisyed5  iWhhc ksaem neess if we ntikh tobau eht otapyphhs of edetveal lC- dna aN unltai.llcrrayle oBht fo etshe osin og pu desiin het llecs deu ot teh tnoeinrte of hte lesmoidfd srpetoin ni the E.RR +
lilyo  I cayullta eagedsri whti tihs irnao.ngse Teh hyipgoootplhasy in TFCR si ont deu ot tauualimnocc fo ledoidfsm t.oreipns It is deu to ebee/sdtsnecdraa ATP datge namarebmrestn diroCehl .nachnle cAicgrndo to drl,oUw het dodscmei nieropt si edtceedt yb the mEiapnoscld u.uelRmcti Teh lmboaran netiopr si treteagd rof ntcteoisdur yb the stpmoareoe dna reenv rcheesa teh llce asucfe.r Three si NO toiteenrn fo ldfdioesm oteiprn, reeht is direogatdna of lmiefddos oneprit nad etofeerhr necaesb of rihdloec sneaclhn on teh bae.rnmem Thsi si hatw dales to paeiirdm avmerol fo aslt ofmr eht wstea as ewll sa eedcesdra lCaN in u.mcsu I odtn ntikh teh enasrw dlhsou be .RE naC onnyae llte em fi I am insmsgi oingstehm hree thta aemks eht earswn RE as soeppod to ymptlos?ac caeBseu the ayw I see fi is fdsmloedi otspreni og ofmr hte ER itno eth lasctomyp ot creah the emostapore dna tnhe eb ctd.sreuted wUldro tiosusqen DI ear 580, ,820 4115, adn 1.939 +19
drdoom  yil@lo eTh RCTF is a tenemaarsnmrb orpnie.t eLki all isrep,not sit aarnltnosit nsgbei ni the cs;otylo ttha ,asdi RFCT ocnistna an enstri-mNu inl“gas cu,qeesn”e hhcwi masen sa ti is nbgie ensdaalr,tt it (nda the brmoosie gmknai )ti! liwl eb sertradntpo to eth omEdnlsiapc ioluucto.on!eeftRt^m sA it sgte staatlr,den tsi odchibrphoy ofismt llwi eeemg,r ihwch sedbem teh TCRF rtinepo tniwih teh hdhpolospipi libryea of het RE !sleitf Taht naesm het eptirno lwli eervn agani eb fodnu ni“ het lsoocty” ebuecsa ti gtse hrddeeta roguthh eth ablirye iwhh(c ,si in tacf, owh all nmsamnreretab pisetnro bcmeeo beamnsnrmreta pnitsreo at het clle acfreus -- ehty evha to eb adme tino trenarsnemmba soipernt ni eth RE f.s)!irt +11
drdoom  lly@oi c)nidnueot( So, e,sy eu,allmttiy esteh omsfiddle tpirsone lliw be drtiedec owradt a aotmeoersp ofr ,dicyloinegdgar/arntce but hatt lwil anppeh as a tiltle lveeics o(r i)“mol;sepo” het idfsmdleo rotnepi, ni ihts aec,s is ton eab-lostrluwe n(s,ice by efontdiini, ti ash hpocrohydib itsmof cwihh egt erd“detha otr”hguh a iayblre to eeract eht maetsarnmrnbe pe,r)ttan hcwhi asmen oyu notw’ ndfi ti in eth to.ycsol +6
drdoom  ^oetnt!ofo : The eentmomv of ct*vaei esbsmoori mrof eht tsycolo ot hte mnilsapcEod meituRluc is yhw we lalc ttha reaa fo RE ugh“ro inlpmoacsEd tleuciumR (R”);rE no eneoltrc omc,srciypo htta seitcon swa bcepslkeed hwti tiltel tdo;s lat,er ew u)nasm(h didrovcees atth etesh stdo reew rbmooe!sis +1
drdoom  * yB a“ectvi eoisb”sm,or I just enma sbmroeosi in hte prosces fo govintnrce NAmR ot tpen!iro ah(Wt we lalc i”asnrantt“ol ); +1
wrongcareer69  How myna nmdaogd ayws ear teyh iongg to tset us on C.F Im' so rove h!sti +2
furqanka  aosl in FA, denru aaplh 1 nsyp,taitrni sti yssa fe'sldoMdi nege tpcdruo oternpi grgasaegte ni elecpulartoalh "RE. mtgih eb het aesm .pecoctn +9
joanmanuel26  cgdicrnoA to Kaan;lp llA opisntre taht rae zdenihsseyt in hte ER must dolf tecrloycr ni orred to be etoprdratsn to the ggiol aasturpa dan ethn ot reiht ifnla etoisdsait.nn If het miouatnt sauce a idmfldseo oipter,n het sturel wlli be eht slos fo eht roneitp tnfnouic d,na ni esmo ,acsse ucilnoatmuca fo eth epoitrn in the R.E +1
drdoom  ily@ol Tgihnkni bauto isth rmeo. You lliw not nfid hte idseo)dml(f etropni ni eht tl.ooysc Teh ddflmseio pitreno mya be iedisn a soonpratmaeed— a pasmoetreo aym veil ni hte t—lbtyosouc eth diofdlmes oirepnt efsitl liwl envre eaaprp ni the tolso.cy ehT ordtuspc of its oantgeddair tgimh estn(tuoctin oianm isadc or llmas ietdesp)p tub fi uoy ahd an aytinobd ofr teh edsoimlfd noetipr nad dksea it Where“ is eht dsoidfeml p?otni,”er eht tonbadyi owldu nasr:we tsM“o of thwa I docul dfni aepsrpa ot eb ni hte rE”.R +
yesa  Cekch out teh nceaxlni lccy,e yuulasl iteosnpr ahtt rea mdea in hte RRE adn edsomidlf etg teadgg adn f'leed'ord nad tneh ancneds agnai orf prepor nganiflo.d..d fi eyht lerayl catn' eb dofdlr,ee 'eerthy aredddeg hnte and eerth! oS het ylon cpeal dmilsedof TCFR udolc acuucmaelt fi fleoisddm siR......R.E Link( ot elnxcnia ecc:ly I.ap50rs5TQ2ccol/g4eAmAVch9=1;w/g;epgEjQihc7vab&.heeaADadhl5ZErxgesD&ohmVwnBI9lswamiprU=t3XoMUesm;tjtmL1aK2Ygp=oU;rWhL8aCr4=YOIji&twA&cr=4sQmiQuasmKs27m1_f9UMpn;bUpgR81g=70oZFoH;2Hm?&asq+w8r=0Aw#bk=vb6sI5ui8D=pe/OBXp8QHaPam:h3:&eyxa+K7&;Ciamh) +
amy  2F200A 7:4 " tnAebs ro cfnliotuydsan RSP ganli(s troiegonicn lreaitc)p esslurt in uimuctcoaaln fo riptneo in het ltyo"soc +
drdoom  mya@, that’s a odog topni tbu it uemsass teh rtiopen is oshtirwee ,rnmloa .e.,i ton domdlifse ro mlnoaar”“b ni emso rhtoe awy +

For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204

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 +4  upvote downvote
submitted by seagull(1933)
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I aehv an siuse hwti shti sqoietnu wchih aosl ntfclocis iwth Wo.rdUl nI rreod ot be rgeedadd yb oomseotsrpe the dlsmiofed oitprne uldow ndee ot be neprets ni het octysol fro n.ioitbuuna tI it tdauumaccel in the RRE hnet woh sode ti get etdag?g t,yoeHsln os c.fl.cneod.ti

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sajaqua1  oS rilyandrio a mdoesildf ioentrp dsoe gunodre uitoubiniatinq adn seplioto.rsy It is elteoban htat TFCR milifgosdn eto'nsd vene oallw ti ceasep het R,E so ti auscuaemtcl ni eht RE +9


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 +4  upvote downvote
submitted by drdoom(1206)
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eTh RTCF penrtio si a aetnmabsmrern tr.onpei ieLk lal t,oipnsre tsi nsirotnatal isbgen ni hte cl;tosoy ahtt d,sia FCRT niostnac na sNemrnui-t alig“sn snequee”,c hchwi sname as ti si ibneg nadsr,aetlt ti (nda eth mobseroi mnikga t!i) will eb todaprrtnes to teh imodnpaEcls micRl^.teuuftono!teo

As it egts l,tatrnsdea sti ohpbdrcohiy itfmos lwli emee,rg hihwc ebmdse hte CRTF ortpeni ihitwn the hpdhpoiilsop eablyri fo the ER elfis!t tahT nmase eht nptroei wlli envre aigna be fdnou “ni eth y”osoclt asebceu ti gset rhatdede hrguhot teh rebyail hcihw( si, ni fc,ta woh lla mesaneabtnmrr tpreions bmceeo tabrmsremnnae eronpsti at hte ellc csrfuae -- tyhe ahve to eb deam otin msbnanearmtre rtpesnio in the ER trf!.)is

oS, y,se ilmut,yelat heets mslfoidde enipotsr ilwl eb dreiedtc rtdoaw a otmroeepas orf ae/clidaero,tinrgdnycg btu hatt illw hpapne as a tillet ecslvei r(o o”l)pmo“ies; eth lsdomidef eoi,nprt in tsih sc,ae is ont lebrotsae-wul ,ic(sen yb oid,ninietf it ash oibdyrphcoh tosifm chwih teg edrd“htae ogruthh” a yaeblri to eatcre hte snmmeabaertnr ,tapnt)er iwhch nmsae ouy wnto’ find ti in teh c.syotol


\ fe!ototon \ The gcthihin of *avtiec sbeosmrio ot het aEimpdsolnc ucemitRul si wyh we clal ttah eraa fo RE o“ugrh ncpdiEmlaos lRtucmeui R;(”r)E on nlorceet ypos,ccoirm atht tneiosc aws bkdeplecse ihwt teillt tsd;o t,lera we mun(has) ddrcvoeeis ahtt teesh sdot eewr bie!roossm

\ * \ By tavie“c rimeb”so,so I jstu nmae rbeisomos ni teh spcsroe fo tocgnneivr ARmN to toprein! hWat( ew call nrnlaosit“t”a );

rFo a teagr ltlite usrmaym of teh aEpidnoclms mRcuuitle n(ad anmy treoh ecnsctop ni louaecrml ooyg)ilb!, ees this rmof lse’tbAr uaMrcolle yoiBogl fo het llCe:
4cn.#:nvhnAibN/b2mw.islstp8/w42.Bgo2o/tK0.o6hw/k1/

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drdoom  ^ 'mI utsj renitgas-t in neo ometcnm waht I tweor in llpmetui eosumtmsbnc eva:bo e921n3xa/3snmtem4ht7w/p/oe9mbe#csbsan.r/:m9/ +

A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257

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submitted by therealslimshady(42)
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hWen spenoirt geibn dmea ni the ER f,dmslio hety amcaeutucl in eth ER, hhwic enht rsgtreig mteh to be tpis out tino the tylocso nad bmoeec gdraeded yb sseomtp.oare ,Tuhs the ccltunamiuao of het feddlsmoi opniter ni the RE si reeirduq for meth ot uiyllttmea eb aedgtg by ituiiuqbn nda eb ddergade ni sareoetp.mso

Enev if oyu eugra tath heyt llwi be amnlgaucutic in hte ysotolc beacesu sereotomspa aer ni teh ys,toloc the iouentsq is sankig ewerh aer eth enpositr tumcgialnauc, tno einbg agedrded. oS htye nc'at mtcalcuuae in teossoerpm,a ubseaec yeht ear otdreydse ni .ethm

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drdoom  iecn chtac ihtw eth “igtamcnuu”lca akrmer! ,qq hewn uyo asy tiggsrre“ etmh ot be tsip uot otin het yloc,”tos do oyu vhea a usroec rfo tht?a tdo'n aelclr rgelinan atth yreweanh .mlsfye !txh +1
therealslimshady  I 'catn mermreeb rwehe I ared ihts tbu ti ukstc hwti em, I iknth it asw a clle ibo bkoo +


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submitted by mutteringly(33)
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hiTs si rfmo bms:oas autetdM RTFC geen 5(8F0Δ atmuotin) → osfdimedl notrepi → efcevidte inreopt is edraniet ni eth uohgr oncplmiedsa riumuetcl )RrE( fro egatdordain → -PaATdteg hrieodcl anclneh si besant on the cell ueasfrc of ileepithal lcsle tuuhorothg hte yobd ,g(..e ittnilsean nda riaosteyrpr te,liaiphe weats gd,lsna roexcnei rapnceas, noecxrei glsadn fo eveurriopcdt )rsnago

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submitted by unknown001(9)
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LAUTR EI.LSMP

ht.e1re are many asrvanit fo tyicsc obssrifi so hsit toenuqsi si ont uaotb pasyt.phyh fo FC

ti2p.no of onutiqse : rwehe dseo porietn nlgdofi crcuo ? swnae)r ERR

  1. IN SHTI YPET FO FC , fi potiner notis fedldo opryrple ni RER lwli ti go tou ro illw ti caueucatlm ? snwa)re it iwll cmuaaucetl in ERR.

IPT : IF OUY EPKE GCESHRNRIAE NO NIAVRSAT FO CF, OUY ERA NO A AHPT OT NEDSESL OOMD

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submitted by blah_blah(1)
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lu eplhfmihg.tl_ajc/habgepInu:uhpo.wGasta/H;ilnbewn3t=u&ywm/cQcwsBvoXNyaoos?=yeft

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submitted by welpdedelp(270)
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g9L2vnte55ngk0_s_242o1mriMgs/P8l/311w270n3s/__a252C5.0./sido_men9Tg24o1/Mn/9pei1y:pte2bh9i8cHhs3/?Fp.3.=

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