need help with your account or subscription? click here to email us (or see the contact page)
join telegramNEW! discord
jump to exam page:
search for anything ⋅ score predictor (“predict me!”)

You must be logged in to vote!
Retired NBME 24 Answers

nbme24/Block 3/Question#46 (reveal difficulty score)
A 15-year-old girl with cystic fibrosis has a ...
Endoplasmic reticulum 🔍 / 📺 / 🌳 / 📖
tags: cell_bio cell_transport cell_trafficking protein_folding

 Login (or register) to see more


 +7  upvote downvote
submitted by vshummy(184)
The site was recently locked🔒
It can be re-accessed by making a purchase.

Purchase your membership here
unscramble the site ⋅ become a member$379$49

I ihtnk remo rlee,galny etponri dfgonli pehnpas ta teh ERR adn het stme yssa hte oeprnti tsndeo’ lodf peo.lpyrr Sliyfccpeia,l eht sotm moncom CF mntoiatu is a solefimdd nproiet dna eht inptreo is rneieadt in teh RRE nda ton rnatrsdpote ot eht lcel rnbmaeem - FA 0912 pg 06.

unscramble the site ⋅ become a member$379$49
uroosisyed5  hichW masek sesne if we tnhik uabto hte hhaystopp fo dlaeetve -Cl dna Na iuteyralllnlr.ac hoBt of ehste nios go pu dnisie eht slcle deu ot het eietnnrto of hte iodmfesdl sretnoip in teh E.RR +
lilyo  I latycaul rdseigae hwti tish ien.ronags eTh hoiagyoptplohsy in TCFR si tno deu ot amnotiucclau fo esddlofim stp.orien tI is eud to ceddsaasee/erntb TPA dtaeg nbntearemmras eirlChod ahl.encn riccoAngd to oUrl,dw eth dscdmeio nripteo si dtectede by the lcmoaEipdns etumiRul.c eTh blrnmaoa irnpeot is gedtrtae ofr cttreosudni yb the temosapreo dna vneer chsaeer eht elcl reauf.sc Theer is ON nnetrotei fo filddoesm tepionr, erthe si gidatdaeonr of elmodsdif iorpnet nda foetehrer ancsebe of idlceroh lcnhnsae no the rbeanmm.e iThs is thaw sdale ot pmiedair rvmloea fo ltas orfm hte etwas sa wlle sa edceserda NCla ni ucsu.m I dnto hnkti eht asrnew louhds be .RE aCn ynenao etll em if I ma msigsni ngotemshi eehr hatt asmek eth rsawen RE sa odppseo ot opacytmls? ceuaesB eht yaw I ese if is msedlifod tepniros og fmor hte ER otin hte ltcpamyso to rceah eth toesmroape dna tneh eb t.tcdudseer dUowrl eqiutnoss ID are 850, ,280 514,1 nad .9139 +19
drdoom  @llioy The TRFC is a emanmnrrsetba i.rontep keLi lal nrps,ieot tis ntnarsoilta enbgsi in teh slyotoc; atht ia,sd CFTR cinnoats na mreutniNs- ng“sail ,ncees”qeu ihwch msean sa ti si nigbe rtdt,elaans it nad( hte ioboresm kangim !)ti lwil eb peratondsrt ot het Eimandpcols ee.tR^tcutoimof!unol As it gtse seardnt,alt tsi idroohbpyhc mtfsio wlli eerm,eg hiwch dmebse the FTCR pitnero niihwt the oodpiishphlp eaiblry fo eht ER it!sefl aTht emasn hte ptirneo will erenv ainag be nufod i“n eth oy”lostc csuebea it gets aetedhdr thruhog hte bylreai iwh(ch is, ni ,fcat who lal embnrtramsaen osetnirp eebcom emresbtananmr sinetrop at teh cell uerfasc -- yhte ehav ot be amde otni ntsnmbremeara rtponesi ni eth ER )sti!rf. +11
drdoom  @loily nc(e)inodtu oS, es,y lultea,mity esthe flsimeodd itpsnroe ilwl be idetedrc daorwt a oosmaepret ofr ingceidrrd,l/tyaaegcno but atth iwll npeaph as a leiltt esvelic or( e;ms)ipol”o“ the ifoesdlmd ori,tpne in shti ,scea is otn b-aleerswtluo ,einc(s yb dtnoieni,fi it has yrbipohohcd tmofsi ihchw egt hd“rtdeea gt”rouhh a lrabeiy to taecre eht ternmrsmanabe pt)t,enra icwhh msena ouy wton’ nidf it ni het co.oltsy +6
drdoom  no!ttf^eoo : heT oeemtmvn fo ic*aevt eoiborsms mofr het yclosot to hte loEpdiamcsn muiectRul si ywh we acll atth raea fo ER “uohrg dsicalnompE iceRulmut ();r”ER on lctoeern ,cosopymcri tath ostniec asw kepseeldbc hwti little tods; lea,tr ew )nh(smua eosiercddv thta etshe sdot weer mo!oisresb +1
drdoom  * yB ecat“vi iembo,o”ssr I sujt aemn bmeoisrso ni the srpseoc of ecgnontvri mARN ot inepo!tr aWth( we llca atn”tsrolnia“ ) ; +1
wrongcareer69  woH myna ongamdd awys are heyt nggoi to test us no .CF 'Im os roev hs!it +2
furqanka  also ni F,A dnrue lapah 1 i,anpystitrn sti assy ifddlosMe' ngee tduprco opntire atggsgeaer in eurltalplaohce "ER. might be the esma oeccntp. +9
joanmanuel26  gciocAnrd to Kanapl; lAl eonpirts taht era ytesehdizsn ni eth RE tmus dofl cctlorery ni oerrd to be dptstoerrna to eht goilg uatsapar nad thne to erhti infla anisiotntsde. fI the nmtuitoa eascu a eomsifddl i,rpnoet eht srlteu iwll eb hte osls of teh ioreptn nnftiocu na,d in soem ,scsea caulunaitmoc fo teh pnoiert in teh RE. +1
drdoom  ll@yio ngTnkhii aotbu isht .eorm oYu lwli ton fnid the loei(md)dsf riptoen ni the ylo.stoc ehT omdisfdle rpnieto amy eb sdniei a adeonperto—sam a srtoaepoem may live in het buycst—ltoo the osdedlifm trioepn lestfi lwil reenv repaap in het s.otlcyo Teh ptdrscuo fo its gdirondaaet ghimt totuscnen(ti imona dscai ro smlal ep)eitdsp ubt fi oyu had na ntaibdoy fro the fdiloedms ntepior nad ksdea it rhWe“e is hte edfsiodml ?opi”ne,tr eht ontbydai oluwd saw:ren oM“ts of hatw I duolc ifdn psparea ot eb ni het r”RE. +
yesa  Cekhc uot hte ianeclxn cyle,c auyslul pstienor tath rea adem ni eht RER nad odemldfis etg ggtdea dna d'r'dlefeo and hten ndesacn aagin fro rrpepo o.i.gldnndaf. fi yeth yrleal tn'ca eb ,eeolfddr eeyhtr' deeddagr ehtn and !reeth oS the lnyo place lfdseoimd RTFC cudlo auulmteacc fi fsdmdoiel E..R..s.i..R (nikL ot laexcnin ey:clc 1XTxhh:pw_die/EgiKRlpm.sgcpa8HaM?8=rc2wA8;P&95lBoamimnaVv9Koa3;:UEIa=2/ims62Uurl8s7=amaOItegbDaQoe1MDksm4m7w8cp+AUbFoZhaptsisXYqIjrm&;hj#Aw/se;c0gaU4wm=&yxOfZprLa5Hgm&I;eC&==Y2Ae47uj&h=pgQAhBQQQt.;U=5og301KtVah7bh&v=WprnLimcC;rHweroe+1bss059D) +
amy  0F220A 7:4 " nebAts or sncinfuoyaldt SRP l(asgni gncnirtooie p)arictle urstels ni ionaumlaucct of tonirpe in hte tsl"ocoy +
drdoom  @,may ’thast a ogod niopt utb ti asusesm teh tpeorin si hwoeerits nalor,m .e.i, otn fismdeldo or mbnaol”r“a in seom hrote ywa +

For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204

+/- drdoom(1206)

You must be logged in to vote!

 +4  upvote downvote
submitted by seagull(1933)
The site was recently locked🔒
It can be re-accessed by making a purchase.

Purchase your membership here
unscramble the site ⋅ become a member$379$49

I haev an iessu tihw sthi uesqnito cwhhi osla tcilsocfn thiw .oUlrdW nI eordr to eb dagedder by tmosseoerop the sdmeloifd oreitpn doluw ende ot be eerstnp ni het clstooy rof ituboun.ain It it uluatcadmce ni teh RER ehtn who dsoe it get ggt?dae o,ntylseH so o.cincd.eltf.

unscramble the site ⋅ become a member$379$49
sajaqua1  So nidyoairrl a odfemlids npiteor osde ngoudre ibiuiontntaiqu and po.rylsosite It is tneoelba atth FRTC dnmofilsig dnteos' enve woall ti saecpe eth ER, so it sletmccauau ni het RE +9


You must be logged in to vote!

 +4  upvote downvote
submitted by drdoom(1206)
The site was recently locked🔒
It can be re-accessed by making a purchase.

Purchase your membership here
unscramble the site ⋅ become a member$379$49

The CRTF notrepi is a ernsemmraantb onertpi. ieLk lal s,rnioept its altroisantn inbegs in hte olsyco;t that ,dais FTRC coinatsn an nmuit-srNe lsi“ang ucee”qe,ns ihhwc mensa as ti is bgein natretlas,d it ad(n eht oiebmsor igmnak !)ti illw eb nteprodtsra ot het pnadEocmisl tumeu.Ri^lcooenft!ot

As ti gste adneslta,rt sit bdoiohyrhcp omtfis illw rgeem,e hiwch seemdb teh CRFT rnoeipt inihwt the lspdophhoipi aylibre fo hte RE tfiesl! tTha eanms teh prteino wlil vneer gaina eb odunf n“i hte ”olytocs eusaebc it stge eehadtrd urhohtg hte lbyaire wcih(h i,s ni ,fcta hwo all neamsrnatbrem inseropt mecbeo embantarmrnse tsenipro at het elcl escuafr -- yeth hvea to eb adem tnio raebamrmsnnte tprsoine in teh RE )tsi.!rf

So, ,eys uttlyal,eim eseht dmseofldi nreptois llwi eb eceidtdr atrowd a torsmeepoa rof nayi,cdtregg/rinealcod tub ttah will hppena as a ltelit veselic o(r ;lpi”e“oso)m eht edsofdiml enirt,op in htis aecs, is tno rlwtel-baueso cin,se( by ion,nfetidi it ahs coobrhyidhp mofsti cwhih etg h“rdedtae oh”htrgu a breiyal to aceert teh mareaermbntsn )ernta,pt icwhh amnse oyu nwto’ fdin it in teh oocly.ts


\ onooeft!t \ Teh chnthigi of vc*eiat omosbesir to the ncalmdiospE telRuicmu si hyw we allc hatt area fo RE g“uroh osEilmpndac mRcliuuet E()”rR; on eetnclor mopycsir,co ahtt ineotsc saw edkceeplbs htwi iletlt sdto; r,leat we (ausnh)m dceisodevr htta teshe tods eerw oseob!smir

\ * \ By i“evcat ”rombsoise, I tjus aenm oimsoebsr ni het eprcoss of evinntogrc RmAN ot tn!oriep a(tWh ew acll st“taao”nriln );

For a aretg eltlti armysmu fo teh pcomlsnEida itumuelRc dan( namy toher teoscnpc in urlleoacm ,)bgl!yoio ees this morf sl’Abetr alcouelrM lByogoi fo eth lelC:
82ist41p2k./h./bwg.NB/l6hotmwsn/o/#2w4v0bnA:iKc.on

unscramble the site ⋅ become a member$379$49
drdoom  ^ Im' tsju ngeiartt-s ni oen tmmcoen htwa I trowe ni eltpulim smmtcbnoues oa:vbe h/ea3sno/e1me.ttpwnmx/:999m2be3ma/#ns7r4bs/c +

A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257

+/- drdoom(1206)

You must be logged in to vote!

 +4  upvote downvote
submitted by therealslimshady(42)
The site was recently locked🔒
It can be re-accessed by making a purchase.

Purchase your membership here
unscramble the site ⋅ become a member$379$49

ehWn pntsrioe iegbn dema ni the RE losdifm, etyh mcaalcuetu ni eht RE, wcihh enth rsgeitrg them to be psit tuo toin het ooscytl adn obcmee egdredad by step.eoamrso suhT, the anumucotclia fo eht isldfeodm rpieotn ni eth RE is dqrerieu fro hmte ot lamtytleui eb taeggd yb ibnqitiuu and eb aegedrdd ni srapet.omoes

Even fi uyo guear atht eyth iwll eb gtcuncaiulam ni hte otcosly bceeuas saeropseomt ear ni the lcstooy, hte ueqitson is ganksi ehrwe are eht itseonrp gmtiaccunual, not iengb ddeaderg. oS teyh tac'n ulacmtcaue ni ser,meosptao abecesu eyth are drytdesoe ni em.ht

unscramble the site ⋅ become a member$379$49
drdoom  cnei hcatc iwth eht mgcuc”ltani“au re!rakm q,q when uyo say git“grres meth ot be ipst uot itno hte l,to”syco do uyo aveh a uresoc for ?ttah 'ondt alclre eilnngar that rwaeeyhn syml.fe ht!x +1
therealslimshady  I 'catn rrbmeeem ewhre I aerd stih tub it tkcus iwht m,e I hktni it swa a lcel obi kobo +


You must be logged in to vote!

 +1  upvote downvote
submitted by mutteringly(34)
The site was recently locked🔒
It can be re-accessed by making a purchase.

Purchase your membership here
unscramble the site ⋅ become a member$379$49

Tish si rfom oms:sab adtutMe FRTC nege Δ(0F85 ttmno)uai → oemflddsi ioetrpn → deifcvtee tneropi is naeedtri in het uhrgo pomiaclsnde uetmuicrl r(E)R fro dgardniteoa → tTPgae-dA hlrcoeid aclhenn is atsben on hte lcel rfuesac of leilaehitp cells ttgohrouhu the ydob g,.e.( naetsinlit adn ryseiatprro eihp,litae ewtsa ndaslg, ceieoxnr a,snraepc neericox lngsda fo oripdteecvru rgo)asn

unscramble the site ⋅ become a member$379$49


You must be logged in to vote!

 +0  upvote downvote
submitted by unknown001(9)
The site was recently locked🔒
It can be re-accessed by making a purchase.

Purchase your membership here
unscramble the site ⋅ become a member$379$49

URLTA .EMSLIP

e.t1her rea aymn aarsinvt fo tiyccs ribossfi os sith sneiuoqt si ont atobu typhay.psh fo CF

t2pi.on fo untsqeoi : eehrw dsoe eptrino lfdinog ruocc ? )wnrase ERR

  1. IN HTSI YEPT OF FC , if nrtpieo osnit edldof lppryero ni ERR iwll it og uto ro lilw it amleautccu ? )rwsena it illw cemucualat in R.ER

TIP : IF YOU KPEE GHRCAENERSI ON NARAISVT OF ,CF OUY RAE NO A APHT TO SELNESD ODOM

unscramble the site ⋅ become a member$379$49


You must be logged in to vote!

 +0  upvote downvote
submitted by blah_blah(1)
The site was recently locked🔒
It can be re-accessed by making a purchase.

Purchase your membership here
unscramble the site ⋅ become a member$379$49

fe lhupl&jeGehybcabwI?y;eN3oQ_vawc:olpBs//h.mnuwmncouhynafgts=tptaXHwitsg/ul.ai=o

unscramble the site ⋅ become a member$379$49


You must be logged in to vote!

 -1  upvote downvote
submitted by welpdedelp(270)
The site was recently locked🔒
It can be re-accessed by making a purchase.

Purchase your membership here
unscramble the site ⋅ become a member$379$49

s_2PHs0ne/pbs2_:4_/te10M5l5=mk.sn214i3goti2g2/cC9.9ey_em_r5Lid3ihnwn5a87/F/o.39/3v1g/MT1?9.s820p1hnp2o2g

unscramble the site ⋅ become a member$379$49


You must be logged in to vote!

Must-See Comments from nbme24

seagull on Intestinal mucosa
tissue creep on Ask the roommate not to smoke in the apartment
drdoom on Adenosine
seagull on Increased serum testosterone concentration
atstillisafraud on Lamins
niboonsh on Only cookies are independently associated ...
atstillisafraud on Scar formation
lamhtu on Decreased adherence
drachenx on Damage to the rectovaginal septum
drdoom on Intestinal mucosa
azibird on Coronavirus
lsmarshall on Organic acid metabolism disorder
sympathetikey on Inhalant abuse
tea-cats-biscuits on Eosinophils

search for anything NEW!