For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204
I hvea na issue wtih iths iunstoqe hcihw sola lfsnotcci itwh .lUordW In rorde to be ddagdree yb soprosteoem eht dfemdlosi oeirntp dwluo eend ot eb ereptsn in teh looytsc fro iub.aontnui tI ti aucmauledtc ni the RRE enth hwo sdeo it egt td?ggea sl,oetynH so lio.fcc.ted.n
ehT RFCT tioepnr is a eemnsranbtarm re.noitp Leki lal otseri,np sti tnlarinatos sngibe in eth oscl;yot ttha dis,a RFTC sictanon an nruetNm-si sanlg“i sceunq”ee, chhwi seman sa it si eignb s,aletnardt it nd(a hte omrobsie akngmi it!) lwli be nsrtptrdeoa to eth clmdonisEpa mut^.cliReuooto!tenf
sA it sgte rdasltatne, sti hbdrhopcyio sfitmo liwl eemer,g hihcw sebemd eth TFRC rtnepio inwtih hte sdippphilooh ebialry fo teh RE sfleti! thaT nesma the priteon illw venre ganai eb odufn “in hte y”colsot aebeucs it sget drheedta otrghuh het lryeiab h(wihc ,is ni ft,ac who lal tanbaeresmmrn isepnrot moecbe emrmnnaseabtr tnspeior ta eth llec aerfusc -- ethy vahe to be aemd oint anembaerrsntm irsenpto ni hte RE )!if.rts
oS, ye,s ,tliyealtum shtee domifsedl rnoiptes lliw be ecdriedt drwtao a speatoomre orf giidar/aencedlto,cngyr utb ttha will pehapn sa a tletil ivlseec (or ei)s;”omo“lp het dfsildmeo et,iornp in htis ,eacs si ton oelea-sbrtuwl nics,(e yb dnfiiio,nte ti ash rdyiboocphh msioft ihcwh egt ehdedta“r ogutrh”h a aeilrby to eetcra het netrsmemanbar a)terp,tn hcwih nasem you owt’n fidn ti ni eht so.loytc
\ ooteno!tf \ Teh ihnhcgti of ct*avei resoimsob to hte odnEamplcis iuumcelRt is ywh we acll that aear fo ER “gruho mdnlcpaEsoi mRuleticu ”;r(R)E no celotrne cos,yicromp htta sceniot swa dcksepeelb htiw ltteli d;ots t,real ew sh(mna)u diesevrcdo hatt tsehe tosd ewer !bomesrsio
\ * \ yB acevt“i i”obmrsos,e I tusj emna oibmoesrs in eht ecsspro of nvrcgeoitn mRNA ot tnoi!rpe h(tWa we clal onrat”t“lnsai );
oFr a great tiltle sramymu of eth plisdamcnoE uitucemlR n(ad ynam trohe pcontsec in cmuloarle o)yb!ol,gi ese stih ormf estAl’rb oluraleMc ogyoliB fo eth ellC:
0/B/.li#cm:hwho..vts.nbwp4n4kbi2K1/Not2g/w62snAo/8
A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257
nWeh ersntpoi ngibe maed ni eth RE fol,dsim hyet umauetcacl in teh ,ER wihch ehtn setrigrg mhte ot be pits otu iotn teh yslooct dna cemeob rdedadge yb aspeem.otors suT,h hte lcuitmucaano fo eht ofemlsdid itnerpo in the ER si eirreudq orf ethm to utmileytla eb ggeatd by ibuunqiit nda eb ddgadere in tm.sapeosoer
Even fi ouy rguea ttha hyte lwli eb ncmiaatulgcu ni teh csytolo cbasuee stemooaserp rea in eht s,coyotl hte eqsntuio is siknag ehewr rea teh intpsoer camnugluatic, otn ngbei edaddreg. oS yeth n'atc uealactcum in otpasoree,ms esaubce teyh aer esydreotd in m.hte
hsTi is rfmo amsbs:o Mtuedta RFTC egen 5(8ΔF0 ton)autim → edsimfldo ntirpeo → detcevief iornpte is nteeriad in hte hrugo eloiasmpcnd ieumucrlt )REr( rfo tednraogida → ateg-TAPd hricedlo hacnnel is btnaes on hte cell frsauec fo ehilpilaet elscl thooutruhg teh bydo eg.(., itlsinaetn adn oisprtrryae ipeielt,ha ewast ,alsdgn noxeicer ns,paecra orencxei salndg of depitocreuvr nrgs)oa
ULTRA PEIMSL.
t1erhe. aer many rnivsaat fo tcsicy sfribiso so isth equsntio si tno abotu phayphts.y of CF
oi2n.tp of nitqosue : whree seod ortnipe ogindfl ouccr ? )nswaer RER
PTI : FI OYU EKPE HNGCSERREAI ON ISVAARNT FO CF, YOU ERA NO A PHAT OT NSLESED OMOD
lplefhu ync=hais/iwIXwcsQpe;ynjuHGt?me.3yo/ueaN.alo_omlhwantgv:btfsacbu/=tgowhBp&
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$279$49 65% OFFI kihnt omre le,nlygrea npietro gifdonl pasneph at hte RER and eth tesm ssay eht prnetio otnd’es fldo lro.erppy ce,lpicflySai eth otsm cnoomm CF umitnato is a edfimsodl eipnrto and hte pitorne is ireneatd in het ERR dan otn dtrtresnpoa to the ecll anrmbeme - AF 2901 pg 0.6
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