For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204
I aehv an siuse hwti shti sqoietnu wchih aosl ntfclocis iwth Wo.rdUl nI rreod ot be rgeedadd yb oomseotsrpe the dlsmiofed oitprne uldow ndee ot be neprets ni het octysol fro n.ioitbuuna tI it tdauumaccel in the RRE hnet woh sode ti get etdag?g t,yoeHsln os c.fl.cneod.ti
eTh RTCF penrtio si a aetnmabsmrern tr.onpei ieLk lal t,oipnsre tsi nsirotnatal isbgen ni hte cl;tosoy ahtt d,sia FCRT niostnac na sNemrnui-t alig“sn snequee”,c hchwi sname as ti si ibneg nadsr,aetlt ti (nda eth mobseroi mnikga t!i) will eb todaprrtnes to teh imodnpaEcls micRl^.teuuftono!teo
As it egts l,tatrnsdea sti ohpbdrcohiy itfmos lwli emee,rg hihwc ebmdse hte CRTF ortpeni ihitwn the hpdhpoiilsop eablyri fo the ER elfis!t tahT nmase eht nptroei wlli envre aigna be fdnou “ni eth y”osoclt asebceu ti gset rhatdede hrguhot teh rebyail hcihw( si, ni fc,ta woh lla mesaneabtnmrr tpreions bmceeo tabrmsremnnae eronpsti at hte ellc csrfuae -- tyhe ahve to eb deam otin msbnanearmtre rtpesnio in the ER trf!.)is
oS, y,se ilmut,yelat heets mslfoidde enipotsr ilwl eb dreiedtc rtdoaw a otmroeepas orf ae/clidaero,tinrgdnycg btu hatt illw hpapne as a tillet ecslvei r(o o”l)pmo“ies; eth lsdomidef eoi,nprt in tsih sc,ae is ont lebrotsae-wul ,ic(sen yb oid,ninietf it ash oibdyrphcoh tosifm chwih teg edrd“htae ogruthh” a yaeblri to eatcre hte snmmeabaertnr ,tapnt)er iwhch nmsae ouy wnto’ find ti in teh c.syotol
\ fe!ototon \ The gcthihin of *avtiec sbeosmrio ot het aEimpdsolnc ucemitRul si wyh we clal ttah eraa fo RE o“ugrh ncpdiEmlaos lRtucmeui R;(”r)E on nlorceet ypos,ccoirm atht tneiosc aws bkdeplecse ihwt teillt tsd;o t,lera we mun(has) ddrcvoeeis ahtt teesh sdot eewr bie!roossm
\ * \ By tavie“c rimeb”so,so I jstu nmae rbeisomos ni teh spcsroe fo tocgnneivr ARmN to toprein! hWat( ew call nrnlaosit“t”a );
rFo a teagr ltlite usrmaym of teh aEpidnoclms mRcuuitle n(ad anmy treoh ecnsctop ni louaecrml ooyg)ilb!, ees this rmof lse’tbAr uaMrcolle yoiBogl fo het llCe:
4cn.#:nvhnAibN/b2mw.islstp8/w42.Bgo2o/tK0.o6hw/k1/
A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257
hWen spenoirt geibn dmea ni the ER f,dmslio hety amcaeutucl in eth ER, hhwic enht rsgtreig mteh to be tpis out tino the tylocso nad bmoeec gdraeded yb sseomtp.oare ,Tuhs the ccltunamiuao of het feddlsmoi opniter ni the RE si reeirduq for meth ot uiyllttmea eb aedgtg by ituiiuqbn nda eb ddergade ni sareoetp.mso
Enev if oyu eugra tath heyt llwi be amnlgaucutic in hte ysotolc beacesu sereotomspa aer ni teh ys,toloc the iouentsq is sankig ewerh aer eth enpositr tumcgialnauc, tno einbg agedrded. oS htye nc'at mtcalcuuae in teossoerpm,a ubseaec yeht ear otdreydse ni .ethm
hiTs si rfmo bms:oas autetdM RTFC geen 5(8F0Δ atmuotin) → osfdimedl notrepi → efcevidte inreopt is edraniet ni eth uohgr oncplmiedsa riumuetcl )RrE( fro egatdordain → -PaATdteg hrieodcl anclneh si besant on the cell ueasfrc of ileepithal lcsle tuuhorothg hte yobd ,g(..e ittnilsean nda riaosteyrpr te,liaiphe weats gd,lsna roexcnei rapnceas, noecxrei glsadn fo eveurriopcdt )rsnago
LAUTR EI.LSMP
ht.e1re are many asrvanit fo tyicsc obssrifi so hsit toenuqsi si ont uaotb pasyt.phyh fo FC
ti2p.no of onutiqse : rwehe dseo porietn nlgdofi crcuo ? swnae)r ERR
IPT : IF OUY EPKE GCESHRNRIAE NO NIAVRSAT FO CF, OUY ERA NO A AHPT OT NEDSESL OOMD
lu eplhfmihg.tl_ajc/habgepInu:uhpo.wGasta/H;ilnbewn3t=u&ywm/cQcwsBvoXNyaoos?=yeft
submitted by ∗vshummy(184)
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$279$49I nitkh reom ene,grlayl noptrie lgodfni nhepspa ta het RER dan hte emst ayss het nptoire tndeo’s dflo plyrpore. iefl,ipalyScc hte tsom mnocmo CF maoitutn si a fidsdmole toenpri dan het prtoein si tedainre ni the RRE nda not oanrsttedpr to eht lcel embmnare - AF 9210 pg .60
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