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Retired NBME 24 Answers

nbme24/Block 3/Question#46 (reveal difficulty score)
A 15-year-old girl with cystic fibrosis has a ...
Endoplasmic reticulum 🔍 / 📺 / 🌳 / 📖
tags: cell_bio cell_transport cell_trafficking protein_folding

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submitted by vshummy(184)
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I ihtnk more yglea,rlne oprinte fgnidol apphsen ta teh RRE dan eht emst syas the oertinp ’tdoens ldof pleyro.rp fc,lpyaiSielc eth mots mnocmo CF niaottum is a omsdefdli rtopien and hte oeirnpt si idretaen in eth ERR nad ton toedsrprant to het lcle emmbearn - AF 0219 gp .60

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uroosisyed5  ihhWc mskae seens fi ew htkin batou eht ohstappyh of taeeldve lC- and aN icataeyl.ulrnllr ohBt of seteh osin go up disein eth sclle due ot teh etnnterio fo the dsdfoieml nitrespo in het ERR. +
lilyo  I tayluacl agreesid wtih hist easgnnir.o The goypipoahtlhoys ni TRCF is nto ued ot iuaumlcontac of deimsldfo i.toseprn It is eud to abnscateedsreed/ TPA tdega msanrbamrntee rCliehod nhclena. rAndgcioc ot lrdo,wU het semddcoi npoteri si dtceeedt by eht inpcdElaosm it.ueRumlc eTh mnrlaoba porietn is eagttrde ofr ortsuenictd yb het otasoeempr adn ervne acehers eth llec .uresacf Trhee is NO ritneonet fo eofmddlis open,tir hrete si dogrnateiad fo sdideomlf oterinp nad fheroerte nacseeb fo dihcrole nhslcnea on het bemrena.m sTih si ahtw dslae ot iiedmrpa lmoraev fo ltas orfm het aestw as lwle as eaeesrddc NlCa in c.musu I notd ihknt teh awnrse sdluho eb E.R Cna naeyno lelt em if I am snigsmi mihtnosge hree thta ekasm teh arsnew RE as pedposo ot p?tysalmco acsueeB teh way I ees if is sedlidfom irtsepno go form het RE iton teh yslomcapt to aerhc teh trsoemeapo dan nhte eb .dedtscrtue Uwlrod nequtsios ID aer ,805 ,280 1,514 nad 3.991 +19
drdoom  iyoll@ Teh TFCR si a maneaerrsbmnt ioep.nrt keiL lla oerpt,sni its anlotnatris bnesig in the los;tcoy atht sdia, TCFR atninsoc na Nristeumn- l“sniga euene,sqc” cihhw amesn as it is ibgen ttndara,els it na(d eht imosbero kaignm )!ti iwll be esarrotndpt to het cEilmdsaopn mou!e^tilctonute.oRf As it tges satentlrd,a ist yobdpohcrih stmifo lliw reg,eme cwhhi sdmeeb eht RFCT ptenrio ihwint the hopisidpphol byrieal of teh ER fe!ltis ahTt mensa het toienpr illw vneer igana be ndouf i“n het yoso”tlc eseucba it gest tehaedrd torughh the ayiblre hw(ich ,si ni caft, how lal enmbtarsaenmr eorpstin emboec reraebansmtmn tnsprieo at the ellc fcuaser -- teyh heva to be amed toin esamrbtrmnnae sonirept in het ER sfi)r.t! +11
drdoom  ll@oiy n()outcenid o,S ,sye myaitut,lel stehe edmdsolfi rnoipest liwl be dtecdrei tdwroa a msotperoae ofr icy/ndgr,tcaeeilodngar utb that lwli apneph as a iltelt ieeclsv (ro p)“oloi;”esm hte dsfedmoli rtoei,np ni siht c,sae is otn aouetbw-sller ,esinc( yb entoifdii,n ti sha bhohyicdrop tfsiom icwhh gte ead“hdtre r”guohht a ibayrle to caerte teh tbesrmearnmna enarpt)t, wihhc nemsa uyo own’t nidf it in teh tyo.cosl +6
drdoom  ^t!onfteoo : The oemntmve fo aev*cit oborsimes ormf teh sctolyo to hte spoicEmdaln elmucRtiu is why we clla ttah eraa fo ER “ruohg acnEmlsipdo ulRuctiem rE)”R;( on relcteon crosypcoim, htta nsieoct was lcesepkdbe hwit tlilet otsd; trael, we mu(ahs)n receddoisv ahtt esthe dots erwe bresoi!som +1
drdoom  * By et“ciav rs,imsbo”oe I tsuj eamn ersoobsmi in eth croseps of cnoevrgtin RAmN ot tiporen! ha(Wt we allc ”ntansa“toril ;) +1
wrongcareer69  woH myna dngoamd ysaw era htye gogin to estt su on FC. 'Im os vore htis! +2
furqanka  sloa in A,F nedru plaha 1 ii,rtntsypna tsi ssya iMd'doself eegn utrdcop enoiptr tsrgaeeagg ni elocetplhlraau "E.R tihmg eb eth easm cpc.oten +9
joanmanuel26  digAcrcon ot apa;lnK All ienprots tath era sietsdynzeh ni het ER tmsu olfd reccorylt in oredr to eb statporrdne ot eht ioglg parstaau and hetn ot etrhi aifnl ttieoniasd.ns If het omtnitua useac a dldmifsoe petoni,r the slrteu wlli eb het ssol fo het nriteop inunfoct and, in esmo escs,a aoumlauicctn fo eth iternpo ni teh E.R +1
drdoom  ll@yio khnginTi bauot ihts e.mro ouY lilw otn dnif the fesd(imod)l inertpo ni the c.oyslto hTe efdisdmol ienorpt aym be niieds a oopee—dantarsm a tamseoepor amy lvei ni eth ybsctlot—ou hte ifdeldmso oiteprn lsfeit will rneve perapa ni the .cytsool heT outpdcrs of its godtedraain hmitg tnoi(ncetust oiman daisc ro smlla eipsdet)p tbu if uoy ahd na yadobint rof teh isdemfodl npeitro dan eaksd it “heWre is teh fdlisemod opt,”i?ern het ybdtoian dluwo sernw:a t“soM fo tawh I uldco ifdn rppeaas to eb ni the REr.” +
yesa  ckChe uot eht nineaxcl ,clyec llsuuay oitresnp taht era edma in the ERR nad odslifedm egt etggda dan dredfel''o nad hent nsenacd ganai for rrepop .ndfag.lnod.i fi thye aeryll ca'tn be e,fdelodr rhet'ey rdaeddeg tnhe adn rte!he oS teh nylo palec lsoifddem FRCT udolc melaucutac fi loiemsddf ..R.R..s.iE. nik(L ot nxelnaic :leycc mrr/gmmsntomIqDmfgA.IhmmUpiYg7b85Q;pwuHL8Qo8uZgVlM_crOwht=o2ehV;&gkpDgeo1a9aacx;hvU;;ascm5iip18oUwt&4U=aMsey3C0wajFAetb/cpAh2maL;3w=8p:T=.XEiAdZp=Ca6h+#rmY7Uexs2Ep=sWKriHaiIaH90K&rncAjs4l7jD1B=0hQbOa=P;=&ae?l&5g9sew1Q&aX45:mRs2Kb+hIo/QeBr&7vs) +
amy  2A020F :74 " stAben ro ntulscydoniaf SRP isnal(g inoioetnrgc c)lrtepai ruetsls in nucmcuoatail fo epoirnt in hte "ctoylso +
drdoom  m,a@y th’tsa a good tpoin tub it sasesum the teiornp is soheitrew lmron,a ,ie.. nto fmsdldioe ro lobnmr“a”a ni eoms teohr way +

For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204

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 +4  upvote downvote
submitted by seagull(1933)
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I vhea na issue tihw sthi sqnteuio icwhh oasl ciloctnfs twih dorWlU. nI eordr ot eb geedrdad yb emtpeorosso hte eldifmosd itnroep uowld nede to be rpeesnt in hte ycotols for ubontinaui. It ti mtclauecaud in the ERR enth owh sdeo ti gte ta?egdg ,nosHtyle so n.cod.tcif.el

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sajaqua1  So iadroilrny a fdoedslim otneipr dsoe nodureg onuttiuniiqbia adn stylireos.op tI si ntbloeea atht TRCF gnfmiidols o'dstne veen lalwo it sceeap hte E,R os it cmsetauuacl in het ER +9


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submitted by drdoom(1206)
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hTe RTCF tniroep si a naatemmerbrns p.noiter kLie lal rt,speoin sit lttarnasnoi bengsi ni teh osyt;clo atth ,idsa RTFC nnoctasi na t-eniusrmN g“alsin ucqn,see”e hicwh smane as it is nibeg snradtalt,e it (dna het semoirob mikagn !ti) liwl eb nartpeorsdt to the pcmEsandilo muetlci^uR.otentof!o

As ti sgte arnldst,eat sit rycdphbhoio osmift llwi eremeg, whihc ebdems eht TFRC retpion nwtiih the phsopoihlpdi reiyabl of het ER flit!se That amesn eth teornip liwl eervn gaina eb nudof “ni the l”tcsooy cauebse it tegs tdereadh tughroh het ilraybe (hwcih ,si in tf,ca woh lla eambrtaesnnmr sniortep ecemob rnterbmanseam iosnprte ta hte lecl ucasrfe -- teyh heav to eb emad niot nntmaerseambr snpreiot ni teh RE t!ifr.)s

S,o s,ey tletuiml,ay ehste eislofddm epinsrot liwl be trdieedc oawtrd a etsmoearpo orf tdn/nyacgocerredil,agi btu tath iwll ppanhe sa a letlti eclsiev or( omil;ope)“”s eth sioldefdm ,tnoprei in iths s,eac is not tebesur-wlola ,neci(s yb iin,inoedft ti has rchdhioobyp mitsof wchih teg “eatherdd oghhu”tr a ylrbaie to carete het enatnermrsabm eptrt,an) hihwc snaem uoy owt’n dnif it ni teh soyt.olc


\ fnoe!otto \ heT nihghcit of ev*iatc sreboisom to hte nodsEpimalc utucleiRm si why we alcl ahtt arae fo RE “ghuor cnloidmspEa emicRluut ”E;(R)r on ceoerltn csoyirmpoc, thta osincet swa bceseeplkd hiwt etltli ;tdso ltear, ew h)sun(am drsdeeivoc ttha heset dtso wree iobos!esmr

\ * \ yB ctvae“i oerm”sbsi,o I jsut anme bmsoosrie ni het sesrpoc fo tioncervng RAmN ot pnoitr!e (athW we call itanrtsaon“”l ;)

orF a gtrae ttille samumry of teh mpnsEdoicla ecimlutuR dn(a nmay eotrh ctsoecpn ni lclauomre ol,o)ig!yb see sthi fmro res’tblA lrMuoaelc golBioy fo eth lleC:
oct.l.t2Ni42b6/knhg.o/ovAh1#s:2n.n8bmi4/KBw/p/wsw0

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drdoom  ^ mI' utsj ttaigse-rn ni noe tomcmne waht I retwo in epltilmu soncmmubtse eaobv: /w//bmnbe3nnopct#:a3x/sr2smm99e/9seatm7h41.e +

A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257

+/- drdoom(1206)

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submitted by therealslimshady(42)
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hnWe tpnesori gbnie made ni teh RE oimfls,d etyh aucctluame ni eth RE, iwchh neht eigtrrsg hetm ot be tips tuo iont the cstolyo dan bmoece dddrgeea yb eet.mpsoasro suh,T eth actoianmculu of teh ilefdsdom teinpro in the RE is ireqdeur for tmeh ot yiaulttlem eb tedgga yb qiniuitub adn be drdedaeg ni saepomso.rte

nveE if you guare that hyte iwll be catmgacunlui in the ysooclt uceaseb eoaspsomter aer in het clso,oty hte setiounq si asinkg heerw ear hte oetspnir tumccagnluai, ont iegbn aeedrdgd. So yeth ctna' aametucclu in srtoseaopem, uaesbec heyt rae etdorsedy in h.met

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drdoom  icne ccath twih eht “cgm”iutucalna rrmke!a qq, wnhe ouy ays igtrsre“g hmte to eb stip uot niot eht clos,y”to od uoy eavh a roesuc rof att?h tdn'o raclle rinenlga ttah rwheneay ys.fmel xth! +1
therealslimshady  I t'can ermebrme hewer I daer hsit utb it sktcu whti em, I itnkh ti was a ecll iob book +


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submitted by mutteringly(33)
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hiTs si from osam:bs dtteMua RFCT geen 5F(80Δ )taoitunm → osdlmfedi irtneop → cidfeteev pnoeitr is deraiten ni het hgrou lnieodpmcas mtuicrlue )Rr(E rfo ageoatndidr → dPgeATa-t lchrdeio elcnnah is beasnt no hte clle sarfcue fo iphleeltai secll hrougouhtt hte bdyo ,eg..( talnitsien dan syaptierror pei,hlaite westa ndalgs, erocnixe ,aenscrpa rieeonxc lgsdan fo rrodpetciuve soragn)

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submitted by unknown001(9)
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LUTRA I.MSLEP

h.1tere era anmy rtnvisaa of ystcic iiosfrbs so stih tqseuoni is nto touab ysphhta.yp fo FC

piotn2. of inqsotue : herew soed iertonp lonfidg ouccr ? wnraes) RER

  1. NI HSTI TYEP FO CF , fi optiren itosn defdol lppoyerr ni ERR lliw it go out ro wlli it ctuumeaalc ? )sraenw it will uumcalctae ni ER.R

PTI : IF UYO EKEP ERERHNAICSG ON ARINVTSA FO F,C UYO REA NO A PATH TO SELSDNE MOOD

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submitted by blah_blah(1)
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uehfpll blent?fspQmiuevyasb3tgIowct=u_nyHaw.lo/i/hpsNcjo&ou.;hahGBaX:/=amcwtegynw

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submitted by welpdedelp(270)
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2eg/s2?3_s.2msg_o1ct2/1.57//=g2hFpoH/0L.5TM2903nki4s2spmh4e/0idvannirw_/t3liyg_pPe8nM.9_15o93b91n1:8C25e

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