For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204
I veha na seusi ithw hsit eitqosnu hwihc salo cltcsnfoi twih loWUr.d nI rrode to be edraddge yb poseremstoo eht eisdomfdl pinreot ludwo dene to be esernpt ni teh olcoyts ofr iuua.onntib It ti aeulmaductc in eht RRE ethn ohw sdeo ti etg ag?tdge Holety,sn so ilocc.tdfne..
hTe RTFC oiptren si a tearrmmaensbn orpinte. iekL all o,tpenirs sit tnoitraslan isengb in the cost;loy hatt d,asi CTFR nactions na setnimu-rN in“lsag ”seqcue,ne cwhih seamn sa ti is igebn rata,lnsdte it (and het rmeiboso ngkami )t!i llwi eb eattpornrds ot the Esadconmpil itR.uuc^elmto!tnoeof
sA it gset denta,asltr its rchodhbiyop otimsf wlil r,gemee hwcih sdmbee eth TRFC nirteop wniith eth dopohplpihsi yaeibrl fo teh RE ei!flts hTat sanem the iorpten lwli vnere giana eb nofud “ni the csooy”lt esbcaue it estg tedharde uhrhgto eht eraiylb whchi( ,si ni fa,ct who lal msarmerabnent tnpsoeri eboecm rnaesbnatmrme rotnpies at teh lelc frscuea -- hyet ahev to eb eadm toin annasrmbmteer openstri ni eht RE ).ifs!tr
,So es,y ,mtieyatlul eshet dfdomslie ieroptns ilwl be dcietrde woadtr a epraotmeso rof egienr,ignyctld/oacrda btu that liwl peahpn as a ttleli vselcie (ro moo)l;“s”pie the eflmosddi en,toirp ni hsti asc,e is ton w-rltbeloeusa (i,necs yb teii,nfdion it ahs chpbdiyoohr itfoms cwihh gte aerdteh“d tg”rouhh a erliayb ot eeactr eth maesnanrmterb rn)aptt,e hhicw semna oyu wton’ nfdi ti ni the ostoy.lc
\ footetn!o \ hTe iinghhct fo *ievtca ebmisoros to the Empocisalnd etuumRcil si wyh we lcal atht reaa of ER o“gurh nmoidEaslpc ecRmuluti )E;”R(r on noelcrte ic,pmscyroo hatt ceosnit swa kpbseeldec whit titlel ;tosd ,earlt we )ahnms(u edircvsdeo taht sehet tosd erwe brioeos!sm
\ * \ yB ice“tva m”bieo,srso I ujts naem ebmirosos ni teh sorspce of tircnogevn mNAR ot eintpo!r (taWh we alcl ”nnaat“isotrl ;)
For a etagr litlet ymusmra of eht moplcdiaEsn ucueltmRi da(n yman otrhe octnpcse in mlelaurco ogyi!b)o,l ees hsit omrf Ars’tbel ocMlearlu oogBliy of hte llCe:
1n.n/6ivmo:/k2.gh4.wN842A/2/icosn#lswotbh.wb0KtpB/
A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257
hWne ostripne begni mdea ni eth RE lifdos,m htey ualccteamu in teh ,ER hhwic thne trgseigr tmeh ot be sipt uto noti teh loytsco nda embcoe ddageder by pr.otssmeoea ,shTu eht icaumclnotau of eht odldsifem nipeotr ni eht ER si reeqdiur fro mhet to ttmuaelily be etgdga by ibitnuuiq nad be dadeedrg ni emroeasto.sp
nveE fi uyo aegur tath htey iwll eb maugctulican ni eht yslcoto scbeuae repoomtaess rea in eht to,syloc teh etuqinos si aingsk erehw rae the troinpes gnlacaiucutm, ton inbge aeeddgrd. oS yeht n'tac uaaumctlec ni osmpteoares, ueeascb ehty rea todedrsye ni t.meh
hTsi is ofmr oasb:ms uadteMt FRCT eeng 0Δ5(F8 nmu)toiat → odsdmflei noreipt → cteedfvei ripetno is edinatre in eht urogh iasemnpodcl euctuimlr (rE)R rof iotradagedn → a-tdgAPTe hrelidoc ncahnle is anbtse no the lelc urcaesf fo ptheaelili lescl hrtugotuoh eht dyob ge,.(. tnslineita adn tpsrirreoay eiteahi,pl etwas ln,gsda nxcereoi ae,asnprc rnxcoeei gdalsn of pertucvedroi )nasorg
ARLUT E.LPISM
rh.eet1 ear ynma nivrtaas fo tcycis fiibosrs os tihs qnusieot is not obaut hsyahyp.pt of CF
.p2otni fo iontqesu : reweh odes onprtei ndgifol ocruc ? )wrnsea RRE
PIT : FI YUO EEPK IGACREHENSR NO ANVSATRI OF FC, YUO RAE NO A THPA OT EELNSSD MOOD
plehu lfHccfNsah3wpysXivaBa;.uu.hc/pib:oQm=wGetenawbyonljnIueos?thmo/lw/g=tt&ay_g
submitted by ∗vshummy(184)
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I hnitk reom leel,ryagn peiotrn dgonlfi ehnsppa at eth RER nad the tmes assy teh otinepr ostned’ fodl rlopr.yep fy,acllipSeci the omst coomnm CF tiamutno si a folseidmd eoitnpr adn teh nertpio is ndearite in hte RER dan nto snpetarrdot ot the clle ermabenm - FA 9201 gp .06