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Retired NBME 24 Answers

nbme24/Block 3/Question#46 (reveal difficulty score)
A 15-year-old girl with cystic fibrosis has a ...
Endoplasmic reticulum 🔍 / 📺 / 🌳 / 📖
tags: cell_bio cell_transport cell_trafficking protein_folding

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submitted by vshummy(184)
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I khitn mreo lnye,lraeg pitnroe ilngodf enphsap ta het RER and eth stme yssa the iprtoen odt’esn ldfo .rloppeyr cpcyS,iliafel teh tmos momonc CF utmintoa si a smfeioldd tneriop adn het ipterno is raentied ni teh ERR nad not ottadpsrenr ot eth llec mrmbenae - AF 0921 pg .60

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uroosisyed5  ichWh aksme esesn fi ew kihtn uotab hte yhostppah of dlaeeetv Cl- dna aN yl.rulacinlraetl Both of ehset nosi og pu iineds eth lsecl due to het oerettinn fo the sedldmoif eporstin ni eth ER.R +
lilyo  I lytlaacu gaiesedr wiht shit engiroa.ns The ohoalsgiytpyohp ni TFRC is tno ued ot matculuiacno fo melisfdod ot.einspr tI is edu to anc/detbesaedsre ATP tadge rerbnmmnestaa oCliedhr elanc.nh ccAgindro ot oU,drlw eth osmedidc rentpoi is deettedc yb hte cnpmdEailos .Rumucteli ehT amlnarbo enitpro si eedgartt rof ontudrtiesc by het asoptmoeer nad rvnee hrcaese het lecl cr.seuaf Teerh si ON inetrtneo of msfoideld eiport,n reeht si ddeanaorgti fo edlfsoimd npeiort adn rhrfeeeot nbcesea fo cioedlhr elannchs on teh .ammreebn Tshi si atwh lsdea to raidepim roavlem of salt omfr het atswe sa lewl as ecrddaese aNlC in u.scum I dotn ktihn het rsanew uodlhs be ER. Cna nyneao tlle me fi I am isinmsg enoismtgh eher htat maske eht wsrean RE sa pdposoe to tclsapo?ym Bacsuee het way I ees fi si fedsmilod epiotrns go from het ER niot the sylmacpto ot eachr hte roetpmaoes nda tenh be rsdctdut.ee lUwdro eitsqsuno ID era 850, 802, 511,4 dan 9391. +19
drdoom  ll@ioy hTe FCRT is a smaamtnenbrre prto.nei eLik lal trnsioep, tis ratoilsntan eingsb in het oclstoy; atht sdai, TFCR natocnsi an inmueNt-rs nsgail“ ”nceuee,qs cwhih ensma sa it si nbige ladrtsen,ta it a(nd eht obimeosr akgimn !ti) illw eb tsandroerpt to het disnoacEplm otRnu.l^ueofoiet!tmc As ti tges tsaenad,rtl sit yprhooihdcb ftimso lliw mre,ege hhwic edmseb eht TFRC tporine whtnii teh ioihpplhpdso aibryel of eht RE isef!tl hTta enmsa the nrepiot ilwl veenr iaang eb noduf n“i hte ooyltc”s ebsaeuc it gtse eradedht ohthugr hte leyrbai hic(wh i,s in a,ctf how lal nrbemmanatesr noprteis coebme mrtmnnreesaba eostnpri ta teh clle seraufc -- htye veha ot be made iton eebrasnamtmrn nriostep in hte RE rfi)t!s. +11
drdoom  loyil@ cd)in(oetun ,So ,yes tlmy,itauel eesht olsidmdef eirtnops lwli eb dretdiec otardw a aesrmeopto fro cangirgi/lrct,edneoyda but ttah iwll hapenp sa a ltteli evseicl ro( ms“lo)e”ipo; het dfdeiomsl rptn,oie in hsti case, si tno lae-rowulestb i(ns,ec by ieitnd,nifo it ahs oodrchihpyb otfsmi whihc get trdae“dhe thgrouh” a irelyab ot aceter het nrmarbemsaten tn),eatrp ihwhc amesn oyu ’twon difn it ni het yco.tsol +6
drdoom  et^ooot!nf : The moenmvet of ica*tve brosseoim frmo teh cotloys to hte mciEspalnod lRuemtiuc is hwy ew llac atht aaer fo ER hgo“ru amcEonspldi ceuitulRm (E)R;r” no rnclteoe yirpoc,osmc atth neocsit saw cdpsekleeb ithw tietll d;ots trlea, ew aus(mhn) oddeevrics ttah heste dsot eewr rb!mososei +1
drdoom  * yB evca“ti b,r”emisoso I tjus mnae iosebsorm ni eth rpsoces of grtnnoivce NRmA to !inrepto Wh(at we lacl ”an“linstorta ;) +1
wrongcareer69  woH yman mdgodan ayws rae ehyt onigg ot ttes su no FC. 'Im so vroe i!ths +2
furqanka  aols ni FA, drune laaph 1 tiayptnni,sr tis syas lifd'Meosd enge cupordt eiptnro sggratgeea in luehelarctlopa E".R htimg be eth easm octep.nc +9
joanmanuel26  odAncricg ot aanKp;l All ntopiesr hatt aer thdzseseiyn in hte ER tusm dolf rrctcoyle ni eordr ot eb raprttndoes to het gogli aaautspr nad hetn to thrie nafli tdsno.aiitsen fI het ttuoniam scaue a fsdioemdl npitoer, hte teuslr illw eb het slos of hte rtiepno tiunofcn an,d in mseo sasc,e acnumalucoit fo eth ntipoer in eth .RE +1
drdoom  loily@ hnigTkin tobau this erom. uoY lliw ton dinf the sode)d(iflm epntoir ni het ycotls.o ehT misdfledo eropnit amy eb niedis a rtdpo—aeesnmoa a oemserpota aym live in het bsltuooc—yt eth dsmdeiolf eoipnrt iftlse lilw evner apaper in the o.otlcsy eTh ustpdocr of tsi nagreaioddt timhg en(ouctitnts minoa dcsai ro lsmal dpe)teips tbu fi you ahd na tobayidn fro eth loidsfemd epnorit and skdae ti “erehW si the elodfsdmi rie”o?npt, the bonaiydt ulowd asewr:n Ms“to fo waht I odclu ifdn epprasa to eb ni teh R.r”E +
yesa  chCek uot het nicneaxl ceycl, uauslyl snpieort thta are amde ni het RER nda dodsefmli teg ggdeat dna 'fre'ddoel and tenh cndsena niaag ofr perrop .gldofa.dn.in if htey laerly 'cant eb d,ederofl hr'etey ddrdgaee hnet dan rhet!e So eht lyno ecalp dmsfeidol CFRT ocudl ucaeactlmu fi dfmdsioel sR....E.Ri.. (kLin to clixanne lcye:c QglbwgamQ&eVhKR3ab=;1+;oAq=t=e7U.Klpotimi8Bgesu0Oi1u8mQs2ZW;ej9aCtVL;AdsQaA#T/5pBogA94hmks:Er9Qriepa?wH502pp=&D=ve2mHvxe3Dc=2iiD8smgtHrfE&XMY8nwb5rUbm;a67apI&a;U1rs&Z=h1IM=scj/hoFUhw+;Ijmm_YsCs7K0LrO=apaIXcmm47gy:r&noow8xal&acha5.PAh/gwh4epUc) +
amy  02AF02 47: " neAbst ro lnfityonacuds PRS s(nalgi engnorcoiit aitlcer)p lussert ni onucaiautlmc fo onpetir in het c"ooyslt +
drdoom  y@,am t’asth a dogo pntio but ti esmsusa het eitrnop is rtihesowe lo,manr .i.e, otn dlifmsoed or ab“m”olran in seom heotr awy +

For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204

+/- drdoom(1206)

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submitted by seagull(1933)
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I eavh na suies htiw htis uisneoqt hchiw losa fcclintos ithw Uro.dlW In rored ot be geredadd by ososroepemt the dmfdsoiel teoinpr olwud eden to eb reentps in the tclsyoo ofr uaoni.nubit tI it duluaemactc in eth RRE then hwo sedo it gte t?geadg ,nyHsloet so .tfceco.diln.

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sajaqua1  So alnroydiri a mlosfdide oinrpet edos gnedruo uoqttiubiannii nad .lootysreisp tI is eeolanbt ttah CRFT onmgdislif e'otsnd enve owlal it pescea eht ,ER so ti cacmuasulet ni eht ER +9


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 +4  upvote downvote
submitted by drdoom(1206)
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eTh CFTR otenpir si a antmersnaermb einrpt.o iekL all tsrpn,eio ist tintaonlras sbengi in eht loysot;c tath asd,i TCFR ntniosac na Ntrien-smu sig“anl ”eu,seceqn hchiw names sa it is eignb etdtslnara, ti (dan teh bimrosoe kminag i)!t wlil be dsetntrrpao ot the daipsEmclno ieRl.tumcu^e!nottofo

As it gste atsne,tdrla tsi hdroobpciyh sitfmo lwli emre,ge hiwhc dmeesb het FTRC toinerp htiwin hte iioospphlhdp rilbaey of eht ER ftl!ise htaT emsan eht riontpe lliw reven aniag eb uodnf “in teh oyos”clt bscaeeu it tges dedather toruhgh eth ibeyarl hi(hcw is, ni c,fta hwo all narremansbtme tospiner cobeme armstenbenmra tneprsio ta eht ellc ceufasr -- eyth haev ot eb mdae otin emsemabnrnrat tesniorp ni hte RE !t)irs.f

,So y,es ,elytmtiaul these dsfolimde itsrnepo will be iceretdd droawt a paesoomtre fro ,nrgedyc/naiotacdigelr tub ahtt lwli ehpapn as a tlilte iclsvee or( om”l)i“se;po eth deifoldsm poi,ernt in hist e,sca si tno eewuolsblrta- c,i(sen yb iintfoine,d ti sha hhpdoboiycr smifto wihhc tge adehed“rt urhtog”h a iblryae ot craete het tenrbarmnmeas )parnet,t hhiwc eanms yuo n’tow find ti ni het .coyoslt


\ efottoo!n \ eTh hhniictg fo ecaivt* mibseosro to teh pdoaEsmclni ulRiuemtc is wyh ew lcal htat aare fo ER rh“uog snidEacpolm uemiRtclu )E(;rR” no otneelrc syc,oopirmc atth ncitsoe aws becdlkpees tihw titlle odt;s a,lrte we am(sh)un csveeroddi htat teshe osdt weer ssm!bioreo

\ * \ yB tc“aive ,sbrsoi”ome I tjus emna oemsiorsb ni the osprsce of geoitnncvr ARNm ot nirt!peo Wht(a we acll n“rltai”tnsao ;)

orF a eatgr letlti ymusamr of eht pnEomsdcila mtuieRcul da(n nmya rohet ctsnpoce ni rlocmelua i!oo)l,gby ese this rmof blAt’ser roceMlual gloiyBo fo het lCle:
si#.482nBs/oc/kK/2/n:pow.liwvtbm2hnogb.0hw.4tAN/61

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drdoom  ^ m'I ujst tin-gtrsea ni one monctem ahwt I orewt ni elmupilt mneosmsutbc v:eboa pn3ao39c#2tmab79:/bem/s1exsmw/4e/hs.rm9tnn/e +

A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257

+/- drdoom(1206)

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submitted by therealslimshady(42)
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hnWe tneorpsi geinb edam ni teh RE somlfi,d tyeh cluctmuaea ni het R,E ihhwc enth gigrerts hemt to eb psit uot iont teh toysocl and beomec dddagree by ermpaoots.es Thsu, the ccalaitnumuo fo the odimsedfl nrtpeoi in het ER is qeirudre ofr ehtm to lumlyetait be gegtad yb quuiibint dan eb reeddgda in ste.rmpasooe

Enve if yuo urgae that htye llwi be ancacutlgmiu ni eht tclosoy ubsaeec sprteooesam ear in hte ocso,ylt het neisquot is nigsak weher rea teh sirnpote umlccgtaaiun, nto ignbe rgedaedd. So htye ntca' eacmutuacl ni msorspo,teae sbecaue thye are eotdedrys in tme.h

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drdoom  inec achct ihtw hte atuilmac”n“cgu !rkamer qq, whne yuo sya “ggrsiret thme ot eb itps uot onti het ”sto,ylco od uoy ahve a cserou orf thta? ntd'o aleclr aielgnnr hatt ehewnyra sfyeml. txh! +1
therealslimshady  I cant' rbermmee rwehe I erda shit btu ti kutcs whti m,e I hiknt ti saw a llce boi kobo +


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submitted by mutteringly(33)
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hiTs si fomr :sbosma eatMtud TFRC ngee F085(Δ mona)iutt → sdfdleiom iepront → etvcfedei ontripe si iteaerdn ni het oguhr oisedmanpcl tumulcrie (Er)R rof rienddtagoa → TdAteagP- drclheio hnenlac si bteans no teh llce sfearuc fo eehipallti llesc horohutgtu teh odby (.g.,e entitianls dna seroatyprir pliet,iaeh setaw dn,lgsa eneicxro ascr,npea ncxoiere dlngsa fo dpieceurtvor gnaro)s

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submitted by unknown001(9)
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ULTRA PMSELI.

e1eht.r rae mnya avartsni of cycits isiofrbs os iths qunteois si nto ubato ysp.hpayht fo CF

pnot2.i of nustoiqe : ewerh eods eptnoir lgiondf uorcc ? )nawsre RER

  1. NI TSHI YETP FO FC , fi ptireno iotsn ddfoel rpoeylpr ni RER llwi ti go tou ro liwl ti ccuauleamt ? awesrn) ti wlli lecacumtua in E.RR

TPI : FI OUY PKEE HCIERRNGAES ON RNAVAITS OF CF, OUY EAR NO A THAP OT SEDSLNE ODOM

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submitted by blah_blah(1)
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llp hfeuogwgc.ttiB3m/aal=?jflX_;aG:co=wevhp.tQsheo/yaIunyeptn/uowns&HmuwNscyhabbi

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eni25_M9iyh__bpCg11/032//92e?5.s30kF2tegLT.n/ho03sP7_8mto29n/s85.nHeval4p=2/cs9n_s:3idg22411M1/miropg.w5

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