For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204
I eavh na suies htiw htis uisneoqt hchiw losa fcclintos ithw Uro.dlW In rored ot be geredadd by ososroepemt the dmfdsoiel teoinpr olwud eden to eb reentps in the tclsyoo ofr uaoni.nubit tI it duluaemactc in eth RRE then hwo sedo it gte t?geadg ,nyHsloet so .tfceco.diln.
eTh CFTR otenpir si a antmersnaermb einrpt.o iekL all tsrpn,eio ist tintaonlras sbengi in eht loysot;c tath asd,i TCFR ntniosac na Ntrien-smu sig“anl ”eu,seceqn hchiw names sa it is eignb etdtslnara, ti (dan teh bimrosoe kminag i)!t wlil be dsetntrrpao ot the daipsEmclno ieRl.tumcu^e!nottofo
As it gste atsne,tdrla tsi hdroobpciyh sitfmo lwli emre,ge hiwhc dmeesb het FTRC toinerp htiwin hte iioospphlhdp rilbaey of eht ER ftl!ise htaT emsan eht riontpe lliw reven aniag eb uodnf “in teh oyos”clt bscaeeu it tges dedather toruhgh eth ibeyarl hi(hcw is, ni c,fta hwo all narremansbtme tospiner cobeme armstenbenmra tneprsio ta eht ellc ceufasr -- eyth haev ot eb mdae otin emsemabnrnrat tesniorp ni hte RE !t)irs.f
,So y,es ,elytmtiaul these dsfolimde itsrnepo will be iceretdd droawt a paesoomtre fro ,nrgedyc/naiotacdigelr tub ahtt lwli ehpapn as a tlilte iclsvee or( om”l)i“se;po eth deifoldsm poi,ernt in hist e,sca si tno eewuolsblrta- c,i(sen yb iintfoine,d ti sha hhpdoboiycr smifto wihhc tge adehed“rt urhtog”h a iblryae ot craete het tenrbarmnmeas )parnet,t hhiwc eanms yuo n’tow find ti ni het .coyoslt
\ efottoo!n \ eTh hhniictg fo ecaivt* mibseosro to teh pdoaEsmclni ulRiuemtc is wyh ew lcal htat aare fo ER rh“uog snidEacpolm uemiRtclu )E(;rR” no otneelrc syc,oopirmc atth ncitsoe aws becdlkpees tihw titlle odt;s a,lrte we am(sh)un csveeroddi htat teshe osdt weer ssm!bioreo
\ * \ yB tc“aive ,sbrsoi”ome I tjus emna oemsiorsb ni the osprsce of geoitnncvr ARNm ot nirt!peo Wht(a we acll n“rltai”tnsao ;)
orF a eatgr letlti ymusamr of eht pnEomsdcila mtuieRcul da(n nmya rohet ctsnpoce ni rlocmelua i!oo)l,gby ese this rmof blAt’ser roceMlual gloiyBo fo het lCle:
si#.482nBs/oc/kK/2/n:pow.liwvtbm2hnogb.0hw.4tAN/61
A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257
hnWe tneorpsi geinb edam ni teh RE somlfi,d tyeh cluctmuaea ni het R,E ihhwc enth gigrerts hemt to eb psit uot iont teh toysocl and beomec dddagree by ermpaoots.es Thsu, the ccalaitnumuo fo the odimsedfl nrtpeoi in het ER is qeirudre ofr ehtm to lumlyetait be gegtad yb quuiibint dan eb reeddgda in ste.rmpasooe
Enve if yuo urgae that htye llwi be ancacutlgmiu ni eht tclosoy ubsaeec sprteooesam ear in hte ocso,ylt het neisquot is nigsak weher rea teh sirnpote umlccgtaaiun, nto ignbe rgedaedd. So htye ntca' eacmutuacl ni msorspo,teae sbecaue thye are eotdedrys in tme.h
hiTs si fomr :sbosma eatMtud TFRC ngee F085(Δ mona)iutt → sdfdleiom iepront → etvcfedei ontripe si iteaerdn ni het oguhr oisedmanpcl tumulcrie (Er)R rof rienddtagoa → TdAteagP- drclheio hnenlac si bteans no teh llce sfearuc fo eehipallti llesc horohutgtu teh odby (.g.,e entitianls dna seroatyprir pliet,iaeh setaw dn,lgsa eneicxro ascr,npea ncxoiere dlngsa fo dpieceurtvor gnaro)s
ULTRA PMSELI.
e1eht.r rae mnya avartsni of cycits isiofrbs os iths qunteois si nto ubato ysp.hpayht fo CF
pnot2.i of nustoiqe : ewerh eods eptnoir lgiondf uorcc ? )nawsre RER
TPI : FI OUY PKEE HCIERRNGAES ON RNAVAITS OF CF, OUY EAR NO A THAP OT SEDSLNE ODOM
llp hfeuogwgc.ttiB3m/aal=?jflX_;aG:co=wevhp.tQsheo/yaIunyeptn/uowns&HmuwNscyhabbi
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$279$49I khitn mreo lnye,lraeg pitnroe ilngodf enphsap ta het RER and eth stme yssa the iprtoen odt’esn ldfo .rloppeyr cpcyS,iliafel teh tmos momonc CF utmintoa si a smfeioldd tneriop adn het ipterno is raentied ni teh ERR nad not ottadpsrenr ot eth llec mrmbenae - AF 0921 pg .60
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