For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204
I vhea na issue tihw sthi sqnteuio icwhh oasl ciloctnfs twih dorWlU. nI eordr ot eb geedrdad yb emtpeorosso hte eldifmosd itnroep uowld nede to be rpeesnt in hte ycotols for ubontinaui. It ti mtclauecaud in the ERR enth owh sdeo ti gte ta?egdg ,nosHtyle so n.cod.tcif.el
hTe RTCF tniroep si a naatemmerbrns p.noiter kLie lal rt,speoin sit lttarnasnoi bengsi ni teh osyt;clo atth ,idsa RTFC nnoctasi na t-eniusrmN g“alsin ucqn,see”e hicwh smane as it is nibeg snradtalt,e it (dna het semoirob mikagn !ti) liwl eb nartpeorsdt to the pcmEsandilo muetlci^uR.otentof!o
As ti sgte arnldst,eat sit rycdphbhoio osmift llwi eremeg, whihc ebdems eht TFRC retpion nwtiih the phsopoihlpdi reiyabl of het ER flit!se That amesn eth teornip liwl eervn gaina eb nudof “ni the l”tcsooy cauebse it tegs tdereadh tughroh het ilraybe (hwcih ,si in tf,ca woh lla eambrtaesnnmr sniortep ecemob rnterbmanseam iosnprte ta hte lecl ucasrfe -- teyh heav to eb emad niot nntmaerseambr snpreiot ni teh RE t!ifr.)s
S,o s,ey tletuiml,ay ehste eislofddm epinsrot liwl be trdieedc oawtrd a etsmoearpo orf tdn/nyacgocerredil,agi btu tath iwll ppanhe sa a letlti eclsiev or( omil;ope)“”s eth sioldefdm ,tnoprei in iths s,eac is not tebesur-wlola ,neci(s yb iin,inoedft ti has rchdhioobyp mitsof wchih teg “eatherdd oghhu”tr a ylrbaie to carete het enatnermrsabm eptrt,an) hihwc snaem uoy owt’n dnif it ni teh soyt.olc
\ fnoe!otto \ heT nihghcit of ev*iatc sreboisom to hte nodsEpimalc utucleiRm si why we alcl ahtt arae fo RE “ghuor cnloidmspEa emicRluut ”E;(R)r on ceoerltn csoyirmpoc, thta osincet swa bceseeplkd hiwt etltli ;tdso ltear, ew h)sun(am drsdeeivoc ttha heset dtso wree iobos!esmr
\ * \ yB ctvae“i oerm”sbsi,o I jsut anme bmsoosrie ni het sesrpoc fo tioncervng RAmN ot pnoitr!e (athW we call itanrtsaon“”l ;)
orF a gtrae ttille samumry of teh mpnsEdoicla ecimlutuR dn(a nmay eotrh ctsoecpn ni lclauomre ol,o)ig!yb see sthi fmro res’tblA lrMuoaelc golBioy fo eth lleC:
oct.l.t2Ni42b6/knhg.o/ovAh1#s:2n.n8bmi4/KBw/p/wsw0
A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257
hnWe tpnesori gbnie made ni teh RE oimfls,d etyh aucctluame ni eth RE, iwchh neht eigtrrsg hetm ot be tips tuo iont the cstolyo dan bmoece dddrgeea yb eet.mpsoasro suh,T eth actoianmculu of teh ilefdsdom teinpro in the RE is ireqdeur for tmeh ot yiaulttlem eb tedgga yb qiniuitub adn be drdedaeg ni saepomso.rte
nveE if you guare that hyte iwll be catmgacunlui in the ysooclt uceaseb eoaspsomter aer in het clso,oty hte setiounq si asinkg heerw ear hte oetspnir tumccagnluai, ont iegbn aeedrdgd. So yeth ctna' aametucclu in srtoseaopem, uaesbec heyt rae etdorsedy in h.met
hiTs si from osam:bs dtteMua RFCT geen 5F(80Δ )taoitunm → osdlmfedi irtneop → cidfeteev pnoeitr is deraiten ni het hgrou lnieodpmcas mtuicrlue )Rr(E rfo ageoatndidr → dPgeATa-t lchrdeio elcnnah is beasnt no hte clle sarfcue fo iphleeltai secll hrougouhtt hte bdyo ,eg..( talnitsien dan syaptierror pei,hlaite westa ndalgs, erocnixe ,aenscrpa rieeonxc lgsdan fo rrodpetciuve soragn)
LUTRA I.MSLEP
h.1tere era anmy rtnvisaa of ystcic iiosfrbs so stih tqseuoni is nto touab ysphhta.yp fo FC
piotn2. of inqsotue : herew soed iertonp lonfidg ouccr ? wnraes) RER
PTI : IF UYO EKEP ERERHNAICSG ON ARINVTSA FO F,C UYO REA NO A PATH TO SELSDNE MOOD
uehfpll blent?fspQmiuevyasb3tgIowct=u_nyHaw.lo/i/hpsNcjo&ou.;hahGBaX:/=amcwtegynw
submitted by ∗vshummy(184)
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$279$49I ihtnk more yglea,rlne oprinte fgnidol apphsen ta teh RRE dan eht emst syas the oertinp ’tdoens ldof pleyro.rp fc,lpyaiSielc eth mots mnocmo CF niaottum is a omsdefdli rtopien and hte oeirnpt si idretaen in eth ERR nad ton toedsrprant to het lcle emmbearn - AF 0219 gp .60
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