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Retired NBME 24 Answers

nbme24/Block 3/Question#46 (reveal difficulty score)
A 15-year-old girl with cystic fibrosis has a ...
Endoplasmic reticulum 🔍 / 📺 / 🌳 / 📖
tags: cell_bio cell_transport cell_trafficking protein_folding

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 +7  upvote downvote
submitted by vshummy(184)
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I hnitk reom leel,ryagn peiotrn dgonlfi ehnsppa at eth RER nad the tmes assy teh otinepr ostned’ fodl rlopr.yep fy,acllipSeci the omst coomnm CF tiamutno si a folseidmd eoitnpr adn teh nertpio is ndearite in hte RER dan nto snpetarrdot ot the clle ermabenm - FA 9201 gp .06

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uroosisyed5  hhWic aeksm snsee fi ew tkhni tbauo the hyhpstopa of vdaeetel C-l nda aN nlaleiuyrll.crta Bhot of htese onis go up dniesi the celsl ued to eth trtnienoe of eht odlmedfsi reptoins ni eth .RRE +
lilyo  I lutacyla eiadresg itwh hsit niegsaon.r hTe ytpolipahsooghy ni CTRF is ont ued ot uaccoimtnual of mdfildose enispr.ot It is ued ot teedrsnec/sadaeb PTA eagtd mambnnsrreaet dorClhie n.cnelha grccniAod ot ,lrowUd het mdeosidc nrpeiot si edectted yb hte andimplsEoc cielut.umR ehT obnmaarl oentpri si eargtdte ofr iucedosttnr by eht ospmraeteo adn enrev escerha hte cell a.ecufrs Teher si ON tieetonrn fo dsdiemofl eitno,pr rethe is gneditdroaa fo diflsoedm eriptno dna eerotfhre enacbes fo oerichdl eansclhn on the mmab.erne hsiT si hwat eadls ot imdeiapr elmroav of alts mfro teh tsewa sa elwl sa erecedsad NlaC in .cumus I ndot ihknt eth nswrea hlodsu be E.R Can naenoy tell em if I am ginimss ehsmingto eehr atth aemks eht sernaw RE as odsopep ot yac?plsmto uceaBes teh yaw I ese if is edfolsdmi teinposr go ormf teh RE onit eht tmpsyoalc to cahre eth eoasemtorp dan nhte eb .duetstcerd Uldowr teqsnious DI aer ,085 80,2 451,1 nad .9391 +19
drdoom  i@olly heT FCRT is a emseatrrbnnma pnrte.io iLke lal nti,psore sit oatnintlrsa nisebg ni het ;oscotly ahtt ,isda FTCR atiscnno na tisr-Nenmu lngi“sa eq,s”enecu chwih nsaem as ti si niegb anlser,atdt ti dn(a eht emiorsob mniakg t)!i lwil eb daoptnsrrte ot hte isEmnaodlcp n^ofo.tti!mlueuoeRtc sA ti segt tadr,tnaesl sti dproychoibh fositm wlil eger,em ihhcw mebsed hte RCFT etnoipr witihn hte lidpopsihhop ibrlaey fo hte RE eilfs!t atTh msean eht oernitp ilwl evnre iaang eb nfdou “in eht ycl”otso ebusaec it esgt deetahdr trhhoug eht bliryea hhcwi( i,s ni tacf, ohw lal bnreatamnmsre osptiern cebmeo besmenrtramna oesrntip at eht llce secfura -- yhet ahve ot eb daem oint amnbtrnmesaer eipsnort ni teh ER t!)fr.si +11
drdoom  oilly@ ued(ocn)nit ,So ,yse tmuitlaly,e eesth seiddfoml siroenpt lliw eb trieecdd twodra a posetaermo ofr ntgdrngyce/irlioea,cda ubt that illw appnhe sa a iltelt ievlsce (or “”plsoioe)m; het idlefmods rient,op in ihts eac,s is not ebsworeatl-lu c(sne,i yb ediiinfon,t ti has ihprbyohcod ftsmio wihhc egt h“eeatddr trg”ohuh a arbleyi ot teaerc eth ametrnmsbaren tertp,n)a hcihw msnea uoy w’ont dnfi ti ni eht costl.yo +6
drdoom  fntt^oooe! : eTh nvoemmte fo cve*tia rsoiesbom fmro hte scloyto to eht splonEcmaid mutluReic is ywh ew llac tath aera of RE hgru“o dEpmcosinla lmciuReut ;(r”R)E on croletne coimocps,ry that csieont aws peebskedlc itwh eltlti ;osdt r,elat we am()snhu oscdeevrdi ttah teehs dots erew !ebmssioor +1
drdoom  * By “itveca ”sisor,emob I tujs aemn somerbios ni het eocsprs of oigncvnter mRNA to n!orpite at(hW we call narlnttasoi“” ); +1
wrongcareer69  wHo aynm gdnmaod ywsa are tehy ngigo to etst us no .FC mI' so ovre t!sih +2
furqanka  laso in F,A nderu halap 1 yittnnri,pas ist says di'sldeofM gene pdcrotu irtnpoe egartagges ni tcrulalleaehpo ".ER ghtim eb eth msae .pncoetc +9
joanmanuel26  drAccogni to paKlna; All ioeprnts thta rea snyzehisdte in eht ER sumt dlof yoctclerr in rorde ot eb prrottdsnea to hte oggil uapsrata dan then to retih ifnla sstiniante.do fI the itnmauto uaces a fiodldmse rtipoe,n hte esutlr llwi be teh loss of the eritnop oftuncni and, ni some cass,e cuioctamulan of the tionrep in the .ER +1
drdoom  oly@li Tiinghkn aubto sthi .mroe uoY llwi nto fidn the dose)(mfild retnopi ni the .otyocsl heT dsfidelom troipne may eb sdniie a ansrpm—teoedao a osemeprota yam eliv ni teh soc—otuybtl het omiddesfl nrietop tflsie iwll neevr pperaa ni the soy.tloc eTh dosurtcp fo sit oaartniddge gimht sntc(oinuett niamo sicda or lslma i)psepted ubt if uyo dah an aiybtodn rof het odelfdism etoipnr and eksad it erWeh“ is hte sdmfieodl norp?”,eit eth abtindyo wldou rnws:ae Mots“ of atwh I uocdl idfn rapaeps ot be in hte .ER”r +
yesa  cehkC tou het enalcinx lcc,ey saulluy setrnopi hatt aer amed in the ERR dan idfslmoed egt gdeagt dna o'eldrf'ed adn nteh encdasn ngiaa orf reropp .gfa.nnido.dl fi ythe aleylr tac'n eb deeo,rdlf 'hertey rdgeedad ehnt dna eter!h So eth ylno peacl deiofmdls TFCR ulcdo caumclaeut fi sfoldmied i....R..ER.s kL(in to lnaixecn cl:cye o2sC+pbKLtr=5mUQjn_faYBpmAs7camXxos9e4sh7hOjht;&9aAHcaU=v#1gsQbMy5eehmbIur=H;m8.m7lig1vOmpm2D/&MdIpe:gxw3&/1VwamH4e;bc9VlgA;=I=eU&a;ruRsak&8cK;pp&/waEQ6gB.wcnW=A3hPsqi2i7gooaAip415?=&LroaUTm:wtiYhea;a=ZE80aeIjUmQ+hFrKr8X5ZD2Dhg8Cslp00oirtQ=sw) +
amy  020A2F 74: " bentAs ro anioutslyfcnd SRP is(lagn iegconnitor tl)pricea rlesuts in lmncuoacatui of onierpt in eht cls"tyoo +
drdoom  m@,ay astt’h a odog otipn tub it assuems teh trnipoe si esithrowe lnm,rao ,.ie. tno fodlmdeis or ab”nmoral“ in seom hreot awy +

For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204

+/- drdoom(1206)

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 +4  upvote downvote
submitted by seagull(1933)
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I veha na seusi ithw hsit eitqosnu hwihc salo cltcsnfoi twih loWUr.d nI rrode to be edraddge yb poseremstoo eht eisdomfdl pinreot ludwo dene to be esernpt ni teh olcoyts ofr iuua.onntib It ti aeulmaductc in eht RRE ethn ohw sdeo ti etg ag?tdge Holety,sn so ilocc.tdfne..

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sajaqua1  So oryiilnrad a fdsleiodm iontrpe deos nogdure iunatioitnibuq nad trlsooep.isy It si netaelob ttah CTFR dfnioigmsl dso'etn vene awoll ti esacpe teh ,RE so it uclsucmaeta in eht ER +9


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 +4  upvote downvote
submitted by drdoom(1206)
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hTe RTFC oiptren si a tearrmmaensbn orpinte. iekL all o,tpenirs sit tnoitraslan isengb in the cost;loy hatt d,asi CTFR nactions na setnimu-rN in“lsag ”seqcue,ne cwhih seamn sa ti is igebn rata,lnsdte it (and het rmeiboso ngkami )t!i llwi eb eattpornrds ot the Esadconmpil itR.uuc^elmto!tnoeof

sA it gset denta,asltr its rchodhbiyop otimsf wlil r,gemee hwcih sdmbee eth TRFC nirteop wniith eth dopohplpihsi yaeibrl fo teh RE ei!flts hTat sanem the iorpten lwli vnere giana eb nofud “ni the csooy”lt esbcaue it estg tedharde uhrhgto eht eraiylb whchi( ,si ni fa,ct who lal msarmerabnent tnpsoeri eboecm rnaesbnatmrme rotnpies at teh lelc frscuea -- hyet ahev to eb eadm toin annasrmbmteer openstri ni eht RE ).ifs!tr

,So es,y ,mtieyatlul eshet dfdomslie ieroptns ilwl be dcietrde woadtr a epraotmeso rof egienr,ignyctld/oacrda btu that liwl peahpn as a ttleli vselcie (ro moo)l;“s”pie the eflmosddi en,toirp ni hsti asc,e is ton w-rltbeloeusa (i,necs yb teii,nfdion it ahs chpbdiyoohr itfoms cwihh gte aerdteh“d tg”rouhh a erliayb ot eeactr eth maesnanrmterb rn)aptt,e hhicw semna oyu wton’ nfdi ti ni the ostoy.lc


\ footetn!o \ hTe iinghhct fo *ievtca ebmisoros to the Empocisalnd etuumRcil si wyh we lcal atht reaa of ER o“gurh nmoidEaslpc ecRmuluti )E;”R(r on noelcrte ic,pmscyroo hatt ceosnit swa kpbseeldec whit titlel ;tosd ,earlt we )ahnms(u edircvsdeo taht sehet tosd erwe brioeos!sm

\ * \ yB ice“tva m”bieo,srso I ujts naem ebmirosos ni teh sorspce of tircnogevn mNAR ot eintpo!r (taWh we alcl ”nnaat“isotrl ;)

For a etagr litlet ymusmra of eht moplcdiaEsn ucueltmRi da(n yman otrhe octnpcse in mlelaurco ogyi!b)o,l ees hsit omrf Ars’tbel ocMlearlu oogBliy of hte llCe:
1n.n/6ivmo:/k2.gh4.wN842A/2/icosn#lswotbh.wb0KtpB/

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drdoom  ^ m'I tjus tgser-inat ni oen etmmnco thwa I rweot in llutepim snscomtbmeu v:ebao 7waeem:mpsbe2axm.9/3//t9t/n#b3hesonr4n/ms19c +

A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257

+/- drdoom(1206)

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 +4  upvote downvote
submitted by therealslimshady(42)
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hWne ostripne begni mdea ni eth RE lifdos,m htey ualccteamu in teh ,ER hhwic thne trgseigr tmeh ot be sipt uto noti teh loytsco nda embcoe ddageder by pr.otssmeoea ,shTu eht icaumclnotau of eht odldsifem nipeotr ni eht ER si reeqdiur fro mhet to ttmuaelily be etgdga by ibitnuuiq nad be dadeedrg ni emroeasto.sp

nveE fi uyo aegur tath htey iwll eb maugctulican ni eht yslcoto scbeuae repoomtaess rea in eht to,syloc teh etuqinos si aingsk erehw rae the troinpes gnlacaiucutm, ton inbge aeeddgrd. oS yeht n'tac uaaumctlec ni osmpteoares, ueeascb ehty rea todedrsye ni t.meh

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drdoom  ienc chtac htwi hte gunc”ictaaul“m ra!rmek ,qq whne uyo ysa r“grestig htem to be tpsi tou iotn teh yo”to,cls do oyu aehv a ocuesr ofr thta? d'not cralel leigrnna atht erywahne .mefsly x!ht +1
therealslimshady  I nt'ca mererbme eerwh I dear hsti tbu ti ktcus twih e,m I nkthi it was a clel oib boko +


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submitted by mutteringly(33)
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hTsi is ofmr oasb:ms uadteMt FRCT eeng 0Δ5(F8 nmu)toiat → odsdmflei noreipt → cteedfvei ripetno is edinatre in eht urogh iasemnpodcl euctuimlr (rE)R rof iotradagedn → a-tdgAPTe hrelidoc ncahnle is anbtse no the lelc urcaesf fo ptheaelili lescl hrtugotuoh eht dyob ge,.(. tnslineita adn tpsrirreoay eiteahi,pl etwas ln,gsda nxcereoi ae,asnprc rnxcoeei gdalsn of pertucvedroi )nasorg

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submitted by unknown001(9)
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ARLUT E.LPISM

rh.eet1 ear ynma nivrtaas fo tcycis fiibosrs os tihs qnusieot is not obaut hsyahyp.pt of CF

.p2otni fo iontqesu : reweh odes onprtei ndgifol ocruc ? )wrnsea RRE

  1. NI ITSH YPTE FO FC , if iterpon ontsi elfodd yperporl in RER wlil ti go uto or wlli it aecucutmla ? )esrnaw it lwli uecaltamcu ni RRE.

PIT : FI YUO EEPK IGACREHENSR NO ANVSATRI OF FC, YUO RAE NO A THPA OT EELNSSD MOOD

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submitted by blah_blah(1)
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plehu lfHccfNsah3wpysXivaBa;.uu.hc/pib:oQm=wGetenawbyonljnIueos?thmo/lw/g=tt&ay_g

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submitted by welpdedelp(270)
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2FngpMs7deytn/.o2og__m1iP3/1inl5m3/:eH/894.2/2/1=2_5s2ssghw_i.M3acpC_9tnkT3ene9vrpg01s?9o10/8h52L5ib04.2

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