For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204
I veha an ussei twhi shti qetusoin hihcw olsa scntcofil hitw UoWl.rd nI erord to be drgadede yb otsosreepmo eth sddioflem inpreot lduow edne to eb neerpts ni hte olctoys ofr nouuinitab. It ti taucmudclea in the ERR hnet who edos ti tge aggdte? nyes,Htol so ftn.ecdo.i.cl
The TCFR oeirpnt si a rmnbaetmasner eoit.nrp keiL lla rpeiostn, sti anotitralns egnibs in eht oslcy;ot that adis, TFCR aocintsn an sn-riuNmet lnai“sg ,ceesque”n hcwhi nmsae sa ti is gnbei rteatlnds,a ti a(nd eht oeiborms nmkgia t!i) lwil eb proerstdant ot het pcnEmdliaos .lecu^umiRtte!onofto
As ti tges ,lsandattre its yrdpcihbooh sotifm wlil mreeg,e chwhi mesebd eth RCFT rnepoit twihni het pphlpoiihdos yerblai of eht ER e!iltsf aTht msnea eth etrnoip liwl evren iagna eb odfun “in hte l”osctyo ausceeb ti segt ddeehrat ugothrh het yriblea hw(ich si, in ,ctaf hwo lal ntsemrabmenar oespntir ceoebm tnraermamesbn iosternp at eht clle sefuarc -- hety evha to eb deam nito aerbtrnmnaems soeirnpt ni het RE i.fts!r)
,oS s,ye tmyileut,al teshe difsmldoe stiroenp lilw eb idrteecd todarw a tpmeoosrea orf ieolncca/ggyn,dredarti utb hatt lilw hpeapn as a telitl levcies (ro oi”em;plo“s) teh elfisoddm toinp,re ni hsti ,saec si not sweru-obellat (inesc, yb tde,iionifn ti ahs irhcdhbpyoo simotf cihwh get arhddeet“ hhruogt” a riaylbe ot earcte eth srebtnrnaemma ptr,tena) iwhhc emsna you tnow’ nfdi ti ni het y.tcoslo
\ n!etoofot \ hTe chithgni of teia*cv obrsoseim to het lcaEidnpsom eimtucRlu is ywh ew clal ttah eraa fo RE h“ogur iasEmnpoldc ectmluiuR ;)(r”RE no lnocteer oi,mrcocsyp atth tcenosi saw dbeclkpees with ltteil ;dots tl,rea we a(mhnus) ecedirovds htta sehet tdos eewr eirob!msso
\ * \ By “taicve oe”brois,ms I usjt eman roeossbmi ni hte csoeprs fo rnvtiogecn ANRm ot tiroep!n tWah( we llca oastnni”a“rtl ;)
orF a greta tilelt msmyrau fo the opmnidElcsa mceuiltRu and( amyn orthe ocpnestc in aclrlmueo igoybl,o!) ees itsh ormf letbrsA’ aeMlourcl ioylgoB of eht lCel:
o28.AtmB:v6N/kos4inwK/h.p0win.tc/hbg212/o/n.w4sl#b
A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257
eWnh torispne ibegn amed in eth RE mf,ildso hyte uteacaclum in eht RE, wchih neth rgestigr tmhe ot be itsp uot otni teh solocty dna mecboe derdegad yb apeemrosso.t uh,sT eth anccamltuiuo of het idfmodles ienpotr ni teh ER is irreeudq fro htme to meytaluilt eb ggdtae yb ntbiuuiiq nda be rgeedadd ni mtroeossap.e
evEn if you ugaer thta yeht lwil be catumnigaluc in teh yotcols usebcea aetmspeosor ear ni hte ,olcsoty het oseiuqnt is gkinas reweh era the rsnioetp nalcuguitmac, otn eingb erddgaed. oS yeth 'atnc mtlauacuce in tsoapsreoe,m eeusbac they rea eotredysd ni thme.
hTsi is form s:mosab tuMatde TFRC geen ΔF8(05 inutaotm) → dlmdoisef tnoreip → cefieetdv ireptno is etaneird ni the guohr aecionlpdsm lectruuim r)R(E ofr tgrdanoeiad → agedAPT-t deorchli enclhan si sbaetn no het llce ecrsafu of tiihpaelle lsecl tuhorhtuog teh boyd ge..,( sinenlatti adn iraeotsprry i,epiatlhe satew sndlag, erieocnx cr,spaean neecroix aldsng of vuerdrceptoi sa)gonr
LUTAR SMLI.PE
e.erht1 rea mnya ntvairas fo ticsyc sbifiosr so this netqiosu is nto auobt pyy.pahtsh fo FC
o2ipnt. fo uqstinoe : weher deos eoirtnp nfgodli coruc ? ansewr) ERR
TPI : FI YUO PKEE CEINRAHGERS NO SVIRANTA FO ,CF YOU ARE NO A PTAH OT ENSLSED OMOD
p flhlueaQmgweu;&wtitna/Nyfvwt?poaiso=m=cuw.oHaltcybsIBXleg_huao.yen/Gshnj:p3hc/b
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I kitnh eorm g,reyallne pnroite fgolidn shapepn at teh RER and teh etsm assy het oneptri dto’nse dolf ppeol.ryr iye,lifacplcS eht tmos nomcmo CF umoittan is a edomlisfd itornep dan het tiropen si ridetnae ni eht RRE dan ont edarnrosptt to the clle manrmebe - FA 1029 pg 60.