For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204
I eahv na ussie ihtw hits tenoqisu which oals sicntoflc hwit WldU.ro nI eordr to eb adeergdd by pesosromote hte dofsdeilm ieopntr luwdo ende to eb sneetrp ni teh ctosloy for uibntiau.on tI it uaeulccmdat ni the RER tnhe how sdeo ti etg eagdg?t ,styeonHl os lctf...ineodc
Teh TCFR eoirtnp si a mrnaenbmtsare rnpto.ie keiL all reint,pos its oanirtltans sginbe ni eth o;oslytc ahtt dsai, RTCF aitnnocs na -ensiNutmr galnis“ esne,cqeu” hcihw semna as it si bnegi leas,dnrtta ti (dan hte ibmeorso iagmnk !t)i lwli be astopterrdn to teh dopaElnmsci ic^uRumelt.ofeo!ntto
As it segt ntdata,rsle sti oprbhcyiohd otisfm liwl ,gemeer hciwh sdmbee eht FRTC nrpteoi itnwih teh sphidpholpio ilybrea fo the ER if!elst Thta nesma het eoitrnp lliw rneve anaig be oufnd “ni het cyoo”stl euescab ti gste trdeahde hrgthuo eth raieylb ihwhc( ,is in tfa,c who all armmtbrnsnaee rstnopie ocmeeb emearsbnrmnta oesnrpit ta the lelc reafsuc -- htey haev ot eb eamd oint ebarmsntamnre entsroip ni teh RE frtsi!.)
So, e,sy tye,lmiltau seeht moilddfse perionst lliw eb eirdedct aodwtr a otpmeerosa orf ,itagcyeroilnndgd/aerc ubt that wlil phpnae as a ttlile ilseecv r(o mpo;“e”losi) het esldidfom ,etrinpo ni siht aces, si not tsre-alluewob sen(,ic by idoinf,enti it ahs hyoircohdpb smtoif hihwc egt hda“eerdt trg”ouhh a yalerib ot cetear eth anebmmarsetnr n,tr)apet hciwh nmase yuo tn’ow dfin it in teh cs.yltoo
\ oettonf!o \ The cginihht fo iavc*te mbsseorio to het ndpocEsmali iRetmuulc si hwy ew lalc htat area of RE “huorg conpslmadEi iuetmculR (;)”RrE on lerncote isopcromc,y ahtt intesco swa dlsbecpeek htiw ttilel ;stdo ter,al ew nhau()sm sidedveocr thta heets sotd erwe miooer!ssb
\ * \ By tvciea“ b”oosmsire, I jstu amne omirsesbo ni het erscops fo ciogenrvnt AmRN to tipoe!rn Wha(t ew clal oi“tnastal”nr ;)
For a rtage liltte musraym fo eth dimcEnspaol eRlumuitc adn( yanm ohert ctpoesnc in lemucoalr )oboyi!g,l ese this ofrm A’rlbtes llceoauMr igyoloB fo hte lleC:
h.Anowwnbb84/g0s/.kl1:Koi#pNs/.t2/mw2/n4ocBthi2.v6
A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257
hWen epsiontr egnbi made in het ER ,ldomifs eyth cealcauumt in het ,ER whhic hnte egsirtgr emht ot be pits tuo toni het oloscty and coembe garededd by operts.asemo T,hus the inamluctcoua fo eht siflddemo iontepr in het RE si rriequde rof htme to ayeilmttlu eb gegdta yb qiuubniti adn be edddgrae in r.mesostaepo
Enev if you eagru atht heyt lwil be nicctalagumu ni hte oyoctls uesbcea eesraosptmo era in hte ocsoytl, eth sntquoei si sakign hrwee aer eht toiprnes munauaigtlcc, otn gbein aededrgd. So yteh c'tna lectuaaumc ni emsasporo,te eebusac htey era drodtseey in .etmh
iTsh is rfom sbsa:mo tedaMut FTRC eneg 580ΔF( tm)tionau → omsdidfel nepoitr → ctdevieef eoirtnp si tenderai in hte ghour dmcoepilnas imreltucu R)r(E for rnotiadegda → PT-Aadteg hiedlroc ahclnen si esnbta no teh clel rasuefc fo llpeiaieth lscel hrughotout eht oybd ,..e(g senatinitl dna rsoaietrryp ,atplieieh waset ald,gsn ceeiorxn nre,spcaa excenori andlgs of ceroeiptdvru ogrs)an
RTAUL IS.MEPL
hree1t. rae amyn rstaaivn fo scyict boifisrs so hsti eusqtino is ton utaob hyp.yaspht fo CF
ino2.tp fo ineutoqs : hewre dose tonprie ofindlg ocruc ? rnwsea) RRE
PIT : FI OUY KEPE ENRSGERIAHC NO ATIASVRN OF F,C YOU REA NO A PHTA TO ESLSEDN OMDO
epul hfl?blIuwaw3watHeftjnuit.ythyhyoh/cansplNme&sp/ociQBnwXcm;u/ooe_.=bvsaga:gG=
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$379$49I nkhit emor nyeaerllg, tnpoeri dflinog espnpha at eth RRE dna eth esmt ysas teh ntipreo de’ntso lofd prypoe.lr llcpyefaSci,i hte stmo cnomom FC itotuanm si a elimfosdd ntoirep dan het nperoti is ertaiden in the ERR nda nto enptdtorsar to hte lelc mmarneeb - AF 1092 pg .60
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