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Retired NBME 24 Answers

nbme24/Block 3/Question#46 (reveal difficulty score)
A 15-year-old girl with cystic fibrosis has a ...
Endoplasmic reticulum 🔍 / 📺 / 🌳 / 📖
tags: cell_bio cell_transport cell_trafficking protein_folding

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submitted by vshummy(184)
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I tnkhi rome yelne,rgal nteorpi idflgno penhpas ta hte RER nad hte stme yass hte eiprtno te’sndo lofd yrlr.poep clyefcpal,iSi the otsm mmcoon CF oainmutt is a flodiemsd ioteprn dan eht irnepto si dtreneai in hte ERR dna ton rpontatersd ot het cell nbrmeame - AF 9120 gp .06

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uroosisyed5  cWhhi mseka enses if we iknth btaou hte syohphtpa fo telveaed -Cl dan aN alulirn.cytearll htBo fo tshee snoi og pu eidins the ellcs ued ot eht titneerno of teh olimdfsde tiorpnes ni eht ERR. +
lilyo  I laatyucl seeradgi wthi tsih ersgonn.ai The hlphaospyygitoo ni CFRT is otn eud to autmlaciocnu of edimfsdlo s.enopirt It is eud to ee/tcaeansedrdsb TPA agted tranaseemrmnb erhiCdol aelc.nnh gdoArncic to rdwlU,o hte dcmedsio enoprti is dtdcteee yb the indcpaElsom .tmuileuRc Teh aobramln nioeprt si gadretet orf itsundeoctr yb teh eoemosrpta nad evern ceaehsr hte elcl rufec.as reTeh si ON itrneeotn fo dsfieldmo etn,pori eetrh si tgornaieadd of ddfoieslm toeprni adn eoetrhrfe bcsaene fo ecirhlod ehslncna no the ream.ebmn shiT si tahw ldsae ot aimirdpe mvoealr of tlas fmor eth eastw as wlle as secraedde NaCl in smcuu. I notd hktni hte wsanre dshlou be RE. naC noeyan eltl me if I ma igsnims sheitonmg ehre tath amsek the saenrw RE as popoesd to pmt?soycla eesuaBc teh yaw I see fi si eodmildsf trpsonei og rofm het RE tnoi hte smyptoacl ot achre teh eaosopmert adn hten be utddec.tser Urdolw seoutisqn ID are 085, ,280 1451, and .9319 +19
drdoom  i@loyl ehT RCTF si a aeasmenrtnbmr teon.rpi ikeL all otirsnp,e sti slntoiatarn sigben in the osyt;col thta sd,ai FTCR nsniatoc na -rsnmiuetN lsgin“a ,”eecqunes ihchw sname sa it si bngei elasdr,atnt it d(na teh mesrooib akgmin i!)t lilw eb rtpoesndtar ot eht cpndslmoiEa !m.Rcutntoieeul^ofto As it etsg trtsaadnl,e its pydoorhcbih simfto will ,geemer cihwh beemsd teh TRFC otipenr whtnii eht iioodpshhlpp byirale fo eth ER t!eslfi aTht esanm eht nrpotie llwi reven igaan be odufn “in eth ocotls”y aesuceb it tges ateddreh ohurght eht balyeir w(chih ,si in tf,ac how lla seaabnnrrtemm srpetoin moeceb nerbsrtaaemmn tiesrpon at eht lecl ecrfaus -- teyh evah ot be made otni mreabterasmnn itporesn in hte RE !istf)r. +11
drdoom  li@oyl e)ctouinnd( ,So ys,e malilutt,ey etesh osemldifd nrtpsioe lwil eb dtdiecer raowdt a rosomeapte for inoarrdeglc/cgeinatyd, btu thta lwil hneapp as a little celives (or e“is”lm;oop) eth eoidflmds pri,oetn in stih ea,sc is not olrseeatl-uwb i,cne(s yb ito,ennidfi it sha pdyhoriobch ofitms ihcwh get erd“dahet ghto”rhu a yairbel ot certae teh ammrearnnestb npte,rt)a cwhih mnsea uoy notw’ fdni it ni the .yotlsco +6
drdoom  ^ntootf!oe : heT emmteonv of *eivact ooissbrem rofm het lystcoo to hte omasdEpncli telcmiRuu is yhw we alcl ttha raae fo ER oguhr“ mocEsidlapn Rticelumu R;E()r” no lrtcnoee rpiy,omcsoc ahtt ticneso wsa bedelcepsk with ieltlt sd;ot erat,l we )nusmha( rsdiveecdo atht sethe dsot wree ribe!ososm +1
drdoom  * By ceva“it rbsom”i,eso I stuj eman embososir ni eht esoprcs fo inorvtcgne NAmR to rno!teip a(Wht we lalc nns”rtoa“tail ) ; +1
wrongcareer69  owH aymn ondmagd sayw era thye nigog ot ttse su on C.F 'mI os eorv !thsi +2
furqanka  oasl in F,A drnue alahp 1 ri,yttinsapn sti assy fildoMes'd eeng putordc enrtiop gtgreeaasg in alrplcuhtleoae ".ER higmt be het smae cnpo.cet +9
joanmanuel26  cnrcogAid to aap;lnK lAl neortspi ttha rea isentzhysed in hte RE stmu odlf coytrrcle in orrde to be tpatnosedrr to hte oiggl aparatsu nad etnh ot ihetr fnali doint.ntsisae If the mutntioa secua a liomfddse ropni,et teh rsluet illw be het sols fo het iernopt fcintoun dan, in smeo cas,es auuliaomnctc fo hte opterin ni eht ER. +1
drdoom  yi@llo ihknTngi btoua tish r.moe Yuo lliw ont fndi the sdo)mil(fed penoitr ni the csolyo.t The lsoefdmdi rtpnoie amy eb eidnis a aoaetropdsenm— a stpeaeoorm amy vile in hte osoclbutyt— teh mfseidodl neritop tielsf will ernve rapaep ni het .soytclo eTh rcpdutso fo its dedtigronaa gtmhi tntisnetu(oc manoi casdi or mslla eep)ptdis btu if oyu adh an odbatyin ofr hte dmdeilsfo teronip dan dskae it “hreWe is eht iedfmodsl np”r?,oiet eth onbdiyta loduw :awnsre “otMs fo hwat I dlouc nifd pesrpaa ot be in eth rRE.” +
yesa  Cckeh out hte nclxaine yelc,c aluuysl erntisop ttha ear made ni teh RRE dan ddlmfieos tge eggtad dan red'e'dlof dan nteh edncnas giana ofr ppreor in..ngofdad.l if tyeh lyarel cna't eb fer,deold yeeh'rt redaedgd thne and hre!te oS eth olny elpca siefdodml FTRC ludoc umtuaecalc if ddfseilmo .iE....R..Rs Li(kn to enlcxain :lceyc Osk;hD&0w_&rrxVajrpKip4i=hpAoerg;9ro&8qs0rmy/8&TLIda5KZ=mg2moaew=Ffmai=52h2lA59:e6+IhB.uEQmOe71QoM7amc&pvs4Um5eQwg=otb;+IrLK;.&peYH88wbwnA=71iiMjjUCQXUE?Wcsgv:Utxa#oaYsZHtleCem;hmpagb=Ba41s&hQnmgs=spaplUhRb1=;Xg72hID0cV3A3icmAHsaaD8;cautP9//w) +
amy  A0F220 47: " nsAetb or fliadnycsonut SRP anis(lg egorconntii rlipeta)c ursstle in mtanaoluucci of tinoepr ni eht osoyt"cl +
drdoom  @ay,m t’stah a ogdo otpin but it amsesus eht tnrpoei si oeetirswh r,lnmao ie.., ton edfildsmo ro ”ba“alrmno ni oesm htoer ayw +

For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204

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 +4  upvote downvote
submitted by seagull(1933)
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I eavh na ssuei tihw tihs esuontiq icwhh osal losfinctc htiw l.UdrWo nI deror ot be deedrdga by etoerspomso teh sfdoleimd ontiper uodlw eden to be erepstn in eht ytlscoo rof abnitnu.iou It it udcaaumectl in eht ERR neth hwo deos ti teg ggat?de yHe,tonsl so dtcn.ciofle..

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sajaqua1  So iyionrrdla a mlsddiefo ptonrie sdeo ugedron noatnbqituiiiu nad stieoylsp.or It si btelaneo ttah RFTC ogdifimnls osdt'ne evne lwalo ti aspeec the ,RE os it ucuamtcesal ni teh RE +9


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submitted by drdoom(1206)
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heT TRCF rnieopt is a marannmertbse etnpi.ro ieLk lal o,tespnri ist arisantlotn biesgn ni the ly;sctoo tath ,disa TRFC atsincon na tuemrisNn- isagl“n eees”uq,cn hwich msane as it is gbeni eatltrsnda, ti na(d teh osomrebi kinmag !)ti liwl eb npasoertdtr to eth aoilmncpEsd cmiul^Rt.euteonf!oto

sA it egts n,sedlartat tsi hoypobchrid tmsiof lwil erem,eg icwhh esbmed eth RTFC opientr hniwit the hlhppsoiodip eiyarbl of eht ER if!setl thTa senam teh pernoit will nevre inaga be ndufo ni“ het ys”cotlo sceuaeb ti tseg rheadted ohghrtu hte ilbyera (hhicw is, ni ,ctfa how lal bnmaenarmtrse otsneipr mceebo rambreanenmst pirstoen at hte lcel eruacsf -- hety heav to be mdea ntoi reseaatbmrmnn stnrpeio ni eht ER !.)firts

,oS ,sey ,laymelttui htsee fomdisedl epiontsr iwll be dreetcdi ortadw a rooaptmsee ofr gdentnriile,caoradg/cy ubt hatt illw ahnepp as a tleitl lciesve o(r oo”“im)slp;e het mefsoddli iprot,ne ni this a,sec is ton l-sreoulaetbw i,en(cs yb tnd,onefiii it hsa robodchyiph sfitom wichh teg edhtd“aer hrogt”hu a bayeilr ot ecaret the ntrmreabnemsa teat,pn)r cihwh ansem you nwo’t idfn ti in eth tosoycl.


\ tootn!feo \ The nhthigci of tivae*c eormiobss to het nmdailcoEps uReuicltm is why ew lcal thta eaar of ER hgor“u cpnlmdoiEas lmctieuRu Er;(”R) no netreocl compsicr,yo thta enoisct wsa eeebspldkc iwht elttil to;ds rel,at ew snuhm(a) sdveeoicdr htta eehts dost rwee orsmsboe!i

\ * \ By vtiae“c mibos”erso, I tjsu amen oerbmosis ni het rocseps fo incngverto NAmR ot pinoe!rt haW(t ew lalc “tlrtas”oinna );

For a aergt ettlil arymmus fo eht pinEdsacmlo iuRumetcl n(ad ynam rteho psetoccn ni ecmrlalou yog!,lb)io see shit form lrtse’bA llaoeMruc Bgloiyo of teh Clel:
nn.sv/4b.2..cmo/tkK68/h2/w12swo4hw:iiBA#bonplgtN0/

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drdoom  ^ m'I jtsu in-grastet in one enmmcot wtah I rwteo in iluepltm csneommusbt aeov:b nease3/ebmmoxpsca939.4#/mn7rh/s/:em/nt2bt1w9 +

A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257

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submitted by therealslimshady(42)
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eWhn ireonpts gienb dmea ni eht ER sim,dolf ehyt tlcmaauceu ni eth R,E hwhic nhet etrgsrgi ehmt to be tips out iotn eht ctsoyol nad ocebem ddaedgre by roaposme.tse shTu, eht ciuunmoclata fo eht eilsofmdd peiortn in het ER is rqrudeei for htme ot tmlutiaeyl eb dggtea by iubqinitu dna be dgdredea in sooseterap.m

venE fi uyo rgaue hatt etyh wlil be ncatilcgaumu in teh ylocots bauecse eomartosspe rae in the tl,soyco teh sutqenoi si sainkg hrewe era hte iorentps gucltamncaiu, otn ngibe dgeedadr. oS tehy nt'ac lauctmucae ni tersmo,paose ceeasbu yhte are reytosded ni h.etm

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drdoom  ince ahtcc twih the galcac”“itumnu !keamrr ,qq nhew uoy asy isrgreg“t them to be tisp uot tion eht ”lyto,cos do uoy avhe a urosce rof tta?h 'dtno eracll rlinnaeg ttah yheranwe eyl.fsm htx! +1
therealslimshady  I ncat' ebeemrrm ehrwe I aedr sith but it tksuc hwti em, I hinkt ti aws a clel ibo koob +


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submitted by mutteringly(34)
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This si fmor bamsso: teaMdut FTCR gnee 5F(0Δ8 ntm)uotai → imodfdles inetpor → ivtdeeefc niotper si eieratnd in eht uhrgo lmisopdncae emucirlut (R)rE rfo aniatdrgode → -tgdTPaeA hiedcrol ennhlac si nbeast on hte lecl curefsa of litilpaeeh lslce ootuthghru eht oydb ,(..eg naesilntti nad eprisytrora iiea,lhpet etaws na,glds xneicore crenaaps, enxrcioe dlsgna fo vecteirrudpo ngros)a

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submitted by unknown001(9)
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LURAT MESLIP.

e1h.ter are mayn vntairsa of stycic sfisobri os sthi isotqneu is ont oatbu ahhtp.sypy of CF

oi.p2tn fo usieqtno : herew esod rpnoeti fnildog uccro ? wr)enas ERR

  1. IN STIH YTEP OF CF , fi teiorpn nitos feldod proprely ni RRE wlil ti og otu or lliw ti amtaulecuc ? n)arwse ti liwl aemtaucucl in RE.R

ITP : IF YUO KEEP EREGRCSHIAN ON SNRTAAIV FO ,CF OUY AER ON A TPAH TO ESDLSNE ODOM

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submitted by blah_blah(1)
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lhupelf &bygyuisttia?tclev_omalnuwBme:;owhp.naa/baN.o3w=g/nH/=sIjoQpuhwyGtcXcfseh

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submitted by welpdedelp(270)
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hl9s2iomHg/d1=.?y/5sn/22781ecgpL2T/9t_gneM34P911.2s1p_Co0nko3wirsa350p3imtn59h2v225_/sFe_.b/:M_.8/0n4ige

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