For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204
I hvae na uesis whti stih ionuesqt hiwhc soal tolscnfci htwi rWlo.dU In dreor ot eb drdedgea by emreootsspo hte fldsdmoie epoitrn wludo dnee ot eb tpseern in the yoslotc for autbinuoin. tI it umacecldatu ni teh ERR ehnt owh dsoe ti gte gat?gde ltoHns,ye so n.cfiodelt..c
The FCRT oirenpt si a nnbmsaaetrmre o.etrnip kieL lal irso,npet tsi rstaanlntio sbinge in teh lostoyc; atht adsi, RTCF ticnaons an senN-tmrui l“agsin ”cueqne,se iwchh asnem sa it si nibeg rtad,elsnat ti (nad eth mbooiers ngaimk !)ti lilw eb rtrepsotadn ot eth apndioclsEm mctR.eui^uloefoontt!
sA ti tsge ndl,treaats tsi copyidhorhb fstoim llwi remege, iwhhc msbeed het RFCT rotipen iwinth teh pihpsdohipol abyeril fo eth ER lfti!se haTt anesm het retiopn wlli vrene ingaa eb uodfn “ni the ”toycsol eucebas it etsg adhetder horgthu the ryilabe chwih( is, in ,tfca hwo all tmabnmneresra psntorie becoem nsbrmmaentear spoinetr ta the lcle urscfea -- tehy heav ot eb eadm ntoi nmembraetanrs orptnies ni teh ER t)!rsif.
,oS sey, tu,amllyite tshee dsmloefid itrpoesn will eb ciredted rdtoaw a otpasmeeor for iio,gcgnteycel/rdnadra btu ttah wlil hapepn as a iltelt ceivesl ro( ;lso”i“om)pe eth demolfisd ronei,tp in iths ,case si otn eowua-ltslreb ,n(sice yb doiietni,fn ti sha hdichorobpy siofmt cwihh tge trd“aehde rthuhgo” a lbraiye to ratece eth rmanntearmbse pra)n,tet hwchi msnea yuo ’nwto fnid ti in the colosyt.
\ tnooo!tef \ eTh gnithhci of iatevc* ebososimr to the dlnsocpmiEa iecuRltum si wyh we lalc ahtt aare of RE oh“ugr Epmscnlaoid eRilutcmu )Rr”(E; on ecroltne yo,pcimrcso ahtt oitcens asw epdkbescle iwth tlleti dost; e,latr we ha)(mnsu esrdiodcve htat eseht stod rwee i!soorsbem
\ * \ yB cveait“ ,srsbooi”me I utsj maen osrmsebio in the cresosp of rnnocigvet RmAN to neorpit! aW(ht we lcla tin“na”lsaort );
oFr a aterg itltel uasrymm fo het mpiEdncasol iRtclumeu (dna many horet opccsten in oreuclaml ),igoylo!b ese siht omrf stebAlr’ alMuleorc oliyoBg of het llCe:
:mt0././blBs.swAw8oK2n#go6c.h4n2ipw/h/nN1/to2ibk4v
A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257
Wnhe oitnsrep egbni meda ni hte ER mi,lsfdo htey uaetmlacuc ni het ER, hicwh then gtersgir htme ot eb sipt uot niot eht loyscto nda cmboee egedaddr yb eoet.srmsopa Tuh,s teh acmlcuuanito fo the dldsomife ientrpo in the RE si edireuqr rof hmet ot tamleuytli be ggdeta yb bniiituuq and eb rgddadee in otesmpe.oasr
vEen if oyu ruaeg ttha ethy ilwl be aluiuncagmtc in het yltscoo eaesubc oeromepsast rea ni teh tcolyo,s hte ieoqutns is ingask ewerh rea eht itosrepn numltuaaiccg, ton iengb agreddde. oS etyh 'catn tceuualamc in speo,aesmrto absucee thye aer orsedteyd ni h.tem
ihTs si orfm smbos:a utetdMa TFCR eeng FΔ5(08 mn)iutoat → ldfmsieod etonpir → eefevditc inrtpeo si earenitd in hte roguh lnaidmcsepo timluceru R(rE) fro orddntaegai → tage-AdTP heocdlri chalenn si abntes no the lcel srcaufe of piahieellt llcse grootthhuu teh bdyo ,(..ge sniltatnie adn srraoireypt ieipaehlt, watse agndls, orneixec cprnsaae, eoxecinr asndgl of ioerpetcvudr grnos)a
UARTL EP.MLIS
1ere.th rea many isaartnv fo cytcis sifsirbo so ihst etnoisuq is not tboua .yhtpyhpas of FC
it2pn.o of nuoesqit : erweh sode rpteino gidlnfo crouc ? sr)nawe RER
TPI : FI OUY EEKP CEHSRNEGARI ON SAATVINR FO ,CF UOY ERA NO A AHTP TO ESESNLD OODM
elulhpf egmXiHysiwaBooh?b;wvc=s.j:ylf3b=u/hyaalgemc/taGQt_onwunhcpan.&NwtuosIe/tp
submitted by ∗vshummy(184)
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$279$49I nitkh rmeo yallngee,r ienpotr fdnlogi ehnsapp ta the RRE adn het mset sysa the tipnero dnoe’st lfdo rppo.rley iyi,alelpccfS eht msto ocmonm FC tinuamot is a sdfedlomi pinetor dna the ireopnt si nidrteea in eht RRE nad tno oendtarpsrt to eth ellc emmarneb - AF 1902 gp 6.0
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