For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204
I eavh na ssuei tihw tihs esuontiq icwhh osal losfinctc htiw l.UdrWo nI deror ot be deedrdga by etoerspomso teh sfdoleimd ontiper uodlw eden to be erepstn in eht ytlscoo rof abnitnu.iou It it udcaaumectl in eht ERR neth hwo deos ti teg ggat?de yHe,tonsl so dtcn.ciofle..
heT TRCF rnieopt is a marannmertbse etnpi.ro ieLk lal o,tespnri ist arisantlotn biesgn ni the ly;sctoo tath ,disa TRFC atsincon na tuemrisNn- isagl“n eees”uq,cn hwich msane as it is gbeni eatltrsnda, ti na(d teh osomrebi kinmag !)ti liwl eb npasoertdtr to eth aoilmncpEsd cmiul^Rt.euteonf!oto
sA it egts n,sedlartat tsi hoypobchrid tmsiof lwil erem,eg icwhh esbmed eth RTFC opientr hniwit the hlhppsoiodip eiyarbl of eht ER if!setl thTa senam teh pernoit will nevre inaga be ndufo ni“ het ys”cotlo sceuaeb ti tseg rheadted ohghrtu hte ilbyera (hhicw is, ni ,ctfa how lal bnmaenarmtrse otsneipr mceebo rambreanenmst pirstoen at hte lcel eruacsf -- hety heav to be mdea ntoi reseaatbmrmnn stnrpeio ni eht ER !.)firts
,oS ,sey ,laymelttui htsee fomdisedl epiontsr iwll be dreetcdi ortadw a rooaptmsee ofr gdentnriile,caoradg/cy ubt hatt illw ahnepp as a tleitl lciesve o(r oo”“im)slp;e het mefsoddli iprot,ne ni this a,sec is ton l-sreoulaetbw i,en(cs yb tnd,onefiii it hsa robodchyiph sfitom wichh teg edhtd“aer hrogt”hu a bayeilr ot ecaret the ntrmreabnemsa teat,pn)r cihwh ansem you nwo’t idfn ti in eth tosoycl.
\ tootn!feo \ The nhthigci of tivae*c eormiobss to het nmdailcoEps uReuicltm is why ew lcal thta eaar of ER hgor“u cpnlmdoiEas lmctieuRu Er;(”R) no netreocl compsicr,yo thta enoisct wsa eeebspldkc iwht elttil to;ds rel,at ew snuhm(a) sdveeoicdr htta eehts dost rwee orsmsboe!i
\ * \ By vtiae“c mibos”erso, I tjsu amen oerbmosis ni het rocseps fo incngverto NAmR ot pinoe!rt haW(t ew lalc “tlrtas”oinna );
For a aergt ettlil arymmus fo eht pinEdsacmlo iuRumetcl n(ad ynam rteho psetoccn ni ecmrlalou yog!,lb)io see shit form lrtse’bA llaoeMruc Bgloiyo of teh Clel:
nn.sv/4b.2..cmo/tkK68/h2/w12swo4hw:iiBA#bonplgtN0/
A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257
eWhn ireonpts gienb dmea ni eht ER sim,dolf ehyt tlcmaauceu ni eth R,E hwhic nhet etrgsrgi ehmt to be tips out iotn eht ctsoyol nad ocebem ddaedgre by roaposme.tse shTu, eht ciuunmoclata fo eht eilsofmdd peiortn in het ER is rqrudeei for htme ot tmlutiaeyl eb dggtea by iubqinitu dna be dgdredea in sooseterap.m
venE fi uyo rgaue hatt etyh wlil be ncatilcgaumu in teh ylocots bauecse eomartosspe rae in the tl,soyco teh sutqenoi si sainkg hrewe era hte iorentps gucltamncaiu, otn ngibe dgeedadr. oS tehy nt'ac lauctmucae ni tersmo,paose ceeasbu yhte are reytosded ni h.etm
This si fmor bamsso: teaMdut FTCR gnee 5F(0Δ8 ntm)uotai → imodfdles inetpor → ivtdeeefc niotper si eieratnd in eht uhrgo lmisopdncae emucirlut (R)rE rfo aniatdrgode → -tgdTPaeA hiedcrol ennhlac si nbeast on hte lecl curefsa of litilpaeeh lslce ootuthghru eht oydb ,(..eg naesilntti nad eprisytrora iiea,lhpet etaws na,glds xneicore crenaaps, enxrcioe dlsgna fo vecteirrudpo ngros)a
LURAT MESLIP.
e1h.ter are mayn vntairsa of stycic sfisobri os sthi isotqneu is ont oatbu ahhtp.sypy of CF
oi.p2tn fo usieqtno : herew esod rpnoeti fnildog uccro ? wr)enas ERR
ITP : IF YUO KEEP EREGRCSHIAN ON SNRTAAIV FO ,CF OUY AER ON A TPAH TO ESDLSNE ODOM
lhupelf &bygyuisttia?tclev_omalnuwBme:;owhp.naa/baN.o3w=g/nH/=sIjoQpuhwyGtcXcfseh
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$379$49I tnkhi rome yelne,rgal nteorpi idflgno penhpas ta hte RER nad hte stme yass hte eiprtno te’sndo lofd yrlr.poep clyefcpal,iSi the otsm mmcoon CF oainmutt is a flodiemsd ioteprn dan eht irnepto si dtreneai in hte ERR dna ton rpontatersd ot het cell nbrmeame - AF 9120 gp .06
$379$49