I hnikt omer rlyng,leae oetrnpi giondfl ephsnap ta teh RER nad teh emts ssay eth nieprto dt’enos olfd rpyeolpr. cpliyaSe,cfli the tsmo nmomco CF minuttoa si a odmsedilf eponirt dna eht piteonr si eertinda ni the RER adn nto ordaeprstnt to teh clel rabmeenm - AF 0129 gp 06.

hTe CRFT prtonie is a rbsmaeaetmrnn t.epinro Lkie lla esinro,tp sit inttlsaonar nibegs in het looyt;cs ttha ,dasi CFTR isntcnao na reNn-tmisu ng“alsi q”se,nceue ihchw measn as it si inebg trsa,ldtaen ti nad( eht oimresbo mnakgi ti)! will be rtenpsoatdr ot hte idalnpmsEco .uucmel^itRetft!ooon

sA ti gtse ,dsrantlaet sit cyrhdbpoohi stomif llwi ,emerge whhci mebdes eht FRCT iprtnoe tniwhi het ophplpdiohsi baeryil fo eth ER s!ltfei aTth neasm teh renipto lilw evner anagi eb onfud ni“ teh tco”lsyo sabecue ti stge terddeah rhgohtu teh irealyb (cihwh is, in cf,at ohw lla esnabrmemntra teonprsi mbceoe ntbmaermeasrn poersitn ta eth lecl asferuc -- tyhe aveh to be amed onit eetarrsbnmamn nseprtio ni hte ER )s!ft.ri

,So e,ys ,yeatlutlmi hetse odmdflise inptorse ilwl be dedcietr towadr a stopoemrae rfo oceg/iiga,alcrdtenrydn tub hatt ilwl nhpape sa a tiltel ilcvees r(o s”mi)po“o;el eth dlmfoeids tropen,i ni sthi asec, is otn aou-slertewbl ,i(senc by dtiinf,ioen it sah ocyripdhhbo mtfois hcwih get h“dredaet gthur”oh a brielya ot tcreea eht snemamarntber ,rattnep) wcihh easmn uyo w’not fdin ti ni the oty.oscl

\ oeftono!t \ ehT ithgihcn of avt*eci bresmosio ot het sEmcponldia iecmtluRu is why ew allc htta aera of ER rgu“ho caoEnsplmid umeRtlciu ”();rER no reoenlct soy,opmiccr tath oesntic asw eksbdclpee twhi ilettl tod;s alrt,e we )m(hunas cdreesviod htat hetes dsot eewr risbosome!

\ * \ yB ivcea“t ”,mirossbeo I stuj eman erssibmoo ni eht peosrcs fo oeinvnrtcg mANR ot ptnoe!ir (Wtah we call inslnat”“troa );

oFr a retag elltit mmsaury fo teh isdloEnpcma itluuecRm dan( namy trhoe soptnecc ni eaoclmulr !,li)oygob see siht ofrm trl’sAbe ecrMalulo igyBloo fo het llCe:
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enhW nstorepi ibnge dmae in eth RE l,omsidf tyeh aumecutalc in teh R,E ihwhc ehtn sirreggt etmh to eb ipst otu noit eth ltsooyc dan mbceoe edgedrda yb .rsaotpoesme huT,s the noaautluccim of the folddmesi otpnier in eht ER si diruereq rfo tehm ot tutalyimle eb dgegat yb bqiutuiin nda eb egrdeadd ni .omospetares

nEev fi uyo graue ahtt hyet lilw eb auualtmncgic ni the ocylost ucbeaes rposseoaemt era ni the ,ctyolos hte uneistoq si kiangs ewhre rea the pnroseit tcigaculanum, not neibg ddaegdre. oS yteh atnc' aleacutcum in esapsroo,etm eescuab yhet era osdrdytee in .hetm

siTh si rfmo smbao:s tMeuatd RTCF gnee 8Δ50(F uttn)ioam → dfmsoeild eornpti → detevcife rtpenoi si earetdni in eht hguor aedomcpinls ecluimrut rE)(R orf ndiaaeotgdr → -aAgdteTP lierhocd necnahl is btanes on the clle rsfecau fo eelthlpiia eslcl thguorutho het bdoy ge,(.. nlsnitatie nda paoritserry lteapeii,h esawt l,adsgn exreinco ,psrcnaea crixeneo ndagsl fo treredicouvp saro)ng

LAURT SIPMEL.

1reh.te era mnay isanartv fo tyicsc boisrisf os sith qstniueo is not autob a.thypyphs fo CF

p2.toni of qoenstiu : hewer eosd rieoptn lndgfio ucrco ? )srwane RER

1. IN TSHI PYTE FO CF , fi nertoip isotn ldoefd rreloypp in RRE lwli ti og uot ro lilw it aeuacmtulc ? nw)aser ti lliw cucelautam in R.ER

TPI : FI YOU EEKP HSEIRECARNG ON AVINTRAS OF F,C YOU REA ON A THAP TO SSELNDE MOOD