For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204
I vhea na isues htiw htsi uitsoneq wihch soal ticsfcoln iwht .oUWlrd In orrde to be dddageer by remopstsoeo teh eddsiofml tiernop lwodu edne to eb srpteen in teh tlooysc for o.baunniuit tI ti acdaculmute in eth RER nhet how osed it egt dat?gge nyoHtsel, so dtneclc..fo.i
Teh TCRF toripne si a namrsrmbatene neo.ptri iLke lal nrpoesit, ist natanlsriot gnsbie in het y;cooslt thta aid,s FCTR ntioascn an Ntrmsie-un “nilgsa eesue,cn”q wichh emnsa sa it si inebg aadrtnet,sl it adn( the ibomeosr igkman !)it ilwl eb rtenortadps ot hte loaicndEmps c^.Rmileutufenoo!tto
sA ti etsg tld,nseatar its cihrybopodh otfmis liwl er,emeg iwhch dbesem eht TRFC renopit iwnhti eth pshholppidoi baiyelr fo the ER e!itlfs Thta nmase het noitepr lwli vreen aigan be uodnf “ni het c”stlooy sbcauee ti setg dthedera thguohr hte rayiebl c(whhi ,si in cat,f ohw lla bnnseararemmt iepnotsr mbeoce msemnratrenab roinptes at the llec furasec -- heyt aveh to be emad toin snmmtranabree psitoner in teh RE .)fris!t
S,o ,yse ,llmueatyti eshte sleddofmi pnterios illw be tecdiedr dtrwoa a peorsatome rof /rrg,ygdaccinnaldoeite utb tath lwil neahpp as a llteti elicvse or( “ops”i)lm;oe het lidsoefmd pontrei, ni ihst ,sace is ton weolbrua-eslt ic,e(ns by ,otnefdinii it ash ocdbryophih mstfio hichw tge ed“rahdet ughhot”r a abyeilr to eeratc eth brnmestmraane ptn),aert hiwch emnsa oyu ’twon nfdi it ni eth stoyc.ol
\ tooeto!fn \ ehT hintcgih fo at*ivec moisbrsoe to teh oicndlaEpms uituemclR si yhw ew call ttha aear of ER r“hugo cdlmpsaniEo uuiclRmet ”R(r);E on lntoerce ioy,scormpc taht stconie saw elsebcedpk tiwh llitet ;sdto r,atle ew )mnhas(u devcodiser that sehet tdso eewr eisoom!rbs
\ * \ By ie“vtac ,moo”issber I tujs amne remobssio in eth psrsceo fo nvnitgeroc AmRN to !tpnerio (athW ew alcl ontsa“”ilrtan ;)
Fro a agetr ltltei mmryusa of eht piacnsdElmo Rumtculei na(d mnya etroh sepncotc ni lrlaomuce y,b!ogl)oi ese hits mrof tbrsA’el Mreloclau ilgyooB fo het lelC:
02ih/:o#o24nwA4Bn2/N/ig.v6pbss/8hmcn/.tlK.otw.k1wb
A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257
eWnh ipntrseo geibn amde ni the RE is,modlf thye cucamelatu in eth ,RE cihwh tenh trseggri ehmt to eb stip tou onit eth oostylc adn bemcoe edeadgdr by .orpssemateo T,uhs eht maouuactciln of teh fiosedmld irnetpo in het RE si urriqdee ofr mteh to ylalettuim eb ggaetd yb iintuqiub dan eb ddeegard ni seotme.srapo
Eevn if uyo uraeg thta ehyt lliw eb icauutlncmag ni teh oltcsoy cbeusae osteespaomr ear in eth s,otoycl the qsinteou si askgni ewehr aer hte isrpotne tucimucnagla, tno inbge gedaedrd. So teyh c'nat tucluamace ni oaesmrpoes,t eeabcus ethy are soddyeetr in .ehtm
sTih si rmof :osbsam aMutetd RCTF gnee 5F0Δ8( t)aunomti → ismdedflo nproite → vcdeietef onrpite is tnaireed ni eht rguho amecolsipnd cimuutlre )(RrE fro rnadtdoegia → -taPgTAde cidhrole enaclhn si snteba on eht llce acefusr of haeiieltlp llesc huthurgtoo hte boyd .e,g(. sneatiintl dan riyeparotrs ,ahepeliit satwe naslg,d rcneeoix c,snaraep oiercenx daglsn fo dvcteoepuirr ao)grsn
LARUT SE.LPIM
.re1teh are many sntvaria of cycits iiorssfb os thsi qtiusnoe si ont uaotb sp.hhpayyt of CF
ip.to2n fo seniouqt : heerw sode reinopt ingdflo corcu ? ewsna)r RRE
TIP : FI OUY EEPK EHSANEGIRRC ON RTVAINSA FO ,CF UOY REA ON A APHT TO EEDLNSS DOMO
puellhfncHjagwuwcta/y_hb.wwpaco?auguonpXse.si&Ie:em=yobiyN/GBantlt=f/l3hshm;Qotv
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$279$49 65% OFFI hnkti more ,ngreaylle pnretio nfloidg nphsaep at eht RRE nad eth mtse yass het rtinpoe desn’to lfod oerrpp.yl aSl,clecipfiy hte tsom omncmo FC uinotatm si a flmesdiod eripont nad teh terinpo is rdteeina in the RER dna nto ptrnoestrda ot teh clle earembmn - AF 1092 gp .06
$279$49 65% OFF