I tnkhi mroe rlnga,eely notprie figodnl phasnep ta hte RER dna the etms ayss het pneoirt ndte’os dlfo elyoprpr. eySc,afilclip teh stmo oomcnm CF aintmotu is a deomdfisl ieotnpr dna eht noerpti si teaenidr ni het RER dan not trrasentpod ot eht ecll menbrame - FA 9201 gp 6.0

eTh CFRT ritepno si a rasnmanmreebt ipoe.nrt kLie lal reonspti, sit slraninotat nbeisg ni teh sylcoto; taht s,adi CRFT nstacino an remtns-iNu n“gsial e”uenqsce, hcihw saemn sa ti si negbi adanre,tlst it an(d teh rsmoeiob igkmna )it! wlli eb drotrpnaset to the Epncomladsi le.^mctuiRunfetoo!to

As it estg trls,edatna sit pdihbrcyooh tsfoim lwil geree,m hhicw seedbm eht CFRT otenipr iihwtn eth poihsiplodhp eiylbra of teh RE fest!il Thta eansm eht tironpe illw nevre gania be fdnuo in“ hte to”ocsly sabceue it gste ehrddtea hthrgou eht elairby h(cihw i,s ni ,ftca hwo lal asnemrtbanmre eintsrpo cmeeob aetearmnsbmrn oipetnrs ta the clel rcefsua -- tyeh veah ot be dame otin mstmrnanbaere etironps in het ER t.fir)s!

So, ,yes tilley,matu etseh elodsdimf opnseitr iwll eb citeerdd twdrao a aeetspomor rfo drntlaicci,egga/oydnre ubt tath will pepahn as a teltil sliceev or( ;m)p”seil“oo eth dmdfsloei oerpi,nt ni shti ,eacs si otn wlrlo-seabtue s,(nice yb idonfne,iti ti has bhdrcoyhiop mtsfoi iwchh egt “adderteh gh”routh a alreybi ot rcetea the emrnnamtbears ,tpena)rt whhci enasm uyo ’wtno dnif it ni hte cyoots.l

\ ootn!oetf \ Teh hngtcihi of ac*vite rmioessob to eth paoEiscmdln iutcemluR is yhw we clla tath aear of RE gohu“r Einmocapsld iclutRemu r”);(ER no teolrecn comyrsci,op atth etcsnoi aws ledskbpcee hwit lttiel ts;od tlar,e we na)(hmsu osecedvrdi thta htese tsod ewer reiosso!bm

\ * \ By e“tvaci smiobose”,r I ustj enam msoersboi ni teh scerpos fo ncorvintge ARNm to tin!eopr (Wath ew allc “astrtnoa”inl );

orF a rtega littel ryausmm fo teh npamEoscldi tuRliecmu adn( nmya troeh npcesotc in cmraouell !,igb)oyol see ihts omfr lAerb’st cMuorllae gBlyioo of teh lleC:
./bhv442bmn1#g:o06lnwt8///cosotiw.p2wN2iA/s.KkBhn.

Whne piesnrot gebni mead in the RE oimd,sfl ethy cluutemaac in het ,RE which tehn tggsrire them ot eb pist out iton the csoolyt dan bemeoc gdarddee yb etmpr.sosaoe Tsu,h eht ucaontilcamu of teh odeldmfis roptein in hte RE is rdqieeur orf mhte to ttemyaulli eb ggtdea by biuntiuqi adn eb geddadre in taeopomres.s

nveE fi ouy eugra thta hety liwl eb tnuacmcaiugl ni teh loycsot ecbsaue mapotsresoe rea ni het ocltys,o hte suetnioq si igakns erewh rea the pitoensr amgiunaucclt, otn geibn adderged. oS etyh n'atc lauucemcta in tampoeress,o usebace yhte ear yteoeddsr in hem.t

Tish is rfmo bmosas: daMutte RTCF eegn 8Δ50F( )tnotmuia → emdlfdsio rpetoni → evitecdef etrnopi is inrdaeet ni eth ogurh moadepiclsn urlceitum r(RE) orf ridaaeogntd → TPg-dtaeA ocheldri nnelhca is bsetan on teh elcl srcuefa fo eltiahlepi ellcs turhugooth het yodb (g.e,. ienitlasnt adn oprsatryeri itelp,ihea ewats ,gdlans exionrce arsnae,pc iroecnex sldgan of ivecreudotrp n)gaors

TARLU IS.LPEM

trh1ee. era amyn trainasv of iycstc iifosbrs so htis snitoueq si ont tuoab ty.hyapsph fo CF

o2pt.in of eqiuosnt : wehre odse prinoet gdonifl crocu ? )raensw RRE

1. IN ISHT YPET OF CF , fi enoprit otnis ofddel pyrrpleo ni ERR ilwl it go tuo ro will ti auaccetulm ? )erawsn it liwl cemuucatal in ERR.

IPT : IF YUO KEPE IEGNRCERSHA NO RAIVTNSA FO ,FC YUO AER NO A APTH OT SELESND OOMD