I ikhnt mreo ,ynelrelag inptroe ofngild panheps ta het RER adn teh tsme syas the ionptre es’dtno lofd lrpoeryp. ccepl,liaSiyf hte otms comnmo FC umtatnoi si a omdesdfli renotpi and het itprone is rnedteai ni eth RRE nad tno nottsrprdea ot the lelc reamebmn - AF 1920 gp 60.

eTh RTCF irpoten is a nmnmsrerbaeta nepi.tor iLek all n,reopsit its rnttoasnial esnbig ni eht slyooc;t tath ,isad FCTR nnasicot na mtenN-irus lg“ansi ee,qn”csue hcwih means as it si gineb ats,alrndet it dna( het eiobsmro nkagim t)i! ilwl be nrsartetodp ot eht adiEsclnpom eltu.mui^Rceonoo!ftt

sA it stge aar,tsdnlte sti orhpidyhboc mtfois illw mgeree, ihcwh ebdmse the FCTR optnire inwiht eth psplpdhiohoi ayibrle fo the ER ifstl!e aTht naems eht ipentro lliw rveen niaga be fnuod in“ the ytsoloc” beuasce it estg dtederah uhhgtro teh byleair ihh(cw ,si ni a,ctf owh lla ramrtaenmsbne psintoer mebeoc sbenmnermarat sntoerpi at the ellc fascure -- tyhe evah to be maed otni mraeanrstenbm pritonse in hte RE sr!fit).

So, sye, iutlayemtl, etseh dfoimleds nesritpo lwli be reidtcde owatrd a seeratmpoo rfo cyedidgalaicngotre,n/r tub taht wlli neaphp sa a litelt vcliese (ro opm”“se);lio het idefdsmlo iorn,tep ni sthi se,ca si ton aete-rluobwls esnc,i( by eniifon,idt ti ahs pcoobdrhyih imotsf chihw egt “ardtdehe rgoh”thu a ibayelr ot craete hte rnatbmmenresa pant)rte, iwchh nasem you tnwo’ dnfi ti in eht oct.osyl

\ onottf!oe \ heT ihhgtcin fo vt*icea moiebssro to eth pniaosEmlcd iRlumteuc is yhw ew llca atth raea of RE horg“u oacsilnmpdE tlucmeRiu R”);r(E no enetcrol coopmric,ys tath ientcos was ecpedsbkle twhi eilttl t;dos etral, we hn(mas)u devcdories atth heets stdo wree sooeibm!sr

\ * \ yB teaciv“ smsrioo,be” I tjsu aemn ssiorobme in het osrescp fo intrvconeg RNAm to r!otpnie hWat( ew lcla ral“nso”iattn ;)

Fro a agter elttli aymusmr fo eth sEplinamdco clRiumtue nda( ynma thoer cetcpsno ni rumelaclo ,oolbi)y!g ees hsit ofmr ltAr’bse oeurlMcla golioyB fo teh lCel:
16bh./hbwsnwi8:/po4.tc/20kB/#4/snAo.m.nKNlvto2g2iw

Whne oetpnsri nebig dmae ni het ER f,doilms htye mtauucaecl ni eth ,ER wcihh tnhe trgeirsg htem to be tpsi uto oitn het ylosotc nad meoecb dadgdree by msa.ersetpoo ,uhsT the tnlocmciauau fo teh misldodfe pioetrn ni eth ER si reedirqu for htem to lmaitytuel be dteagg by uubitnqii nad eb rgddeade ni roesoe.tsmap

vEne fi ouy raegu ttha ythe wlil be anlgcmacuitu in eht slcotyo besaecu aoperomstes ear in eht tclos,yo eht osqntiue si ignaks hwere rea the iopstrne iaanccuutlmg, tno ingbe gadredde. oS hety acn't alceutmauc in m,sasoterpoe easucbe thye ear dsyeroted in emt.h

sTih si fmor :sobmas atedtuM TCFR nege 580(FΔ i)ttaounm → mefldsoid pirento → ieetfdvec oinrtep is eineatdr in teh oghur peidsclaonm mruucetil R)r(E fro aonrgeidtad → gPTta-edA orhecdli lenahcn is esbatn no eth llce rsceafu fo ehtpaieill eslcl uuhtoghrot eth yodb ..(,ge nntsliaite nad rprytiosrae letiapei,h tseaw ,sldnag irnoeecx esacan,pr oeirxecn adgsnl of utcdeiroprve sog)nar

TLRAU EIMPLS.

rhe.te1 ear many tiarasvn of cycsti issobirf os this tsqioeun is ont autbo hypa.ysthp fo FC

2npio.t fo iutqseno : heerw dose ptneroi lgindof corcu ? wa)senr ERR

1. IN ITSH TPYE OF CF , if eirptno stnio edfdlo pprryole in RER lwil ti go uot ro wlil it umualcteac ? raw)nse it wlli caeualcutm in ER.R

ITP : FI OYU EKPE GNRSAHREICE ON TNASVRIA OF ,CF OUY AER NO A PHAT OT SSLNEED OODM