You must be logged in to vote!
I realise now that diarrhoea causes hypernatremia!
And the reason we give ORS is to restore the blood pressure by giving Na and Glu not to correct sodium level!
My 6 yr of medical education was a myth
You must be logged in to vote!
sbryant6
I'm going to go take a big bicarbonate poop now.
+32
happysingh
i would suggest that you look into it a bit more. Why ?
Had an nbme question (which confused the shit out of me) cuz, Bluemic Pt. who was abusing Laxatives (had the up & down arrows) and this is what it gave :
Laxative Abuse — Metabolic Alkalosis :
↓K+ ↑Cl- ↑pH ↓HCO3-
so one of the points of distinction IS the increase in Cl- with laxative abuse (vs. vomiting, which was a knee-jerk reaction when i hear bulimia)
+3
lola915
I thought diarrhea causes Non anion gap metabolic acidosis @happysingh
+2
texasdude4
easy way to remember : "Bicarb out the Butt"
+2
weirdmed51
doesnt acidosis result in 'HYPERkalemia'?
+1
You must be logged in to vote!
You must be logged in to vote!
liverdietrying
I think you over-thought this one a little bit with the hypercalcemia/hyperuricemia. Good fact to commit to memory: you lose bicarb in the stool (hence why diarrhea causes nonanion gap metabolic acidosis), and especially lose potassium with laxative abuse (as mentioned in the question stem). https://www.uptodate.com/contents/acid-base-and-electrolyte-abnormalities-with-diarrhea
+3
w7er
Basically they are asking about electrolyte distrubance that cause collapse mainly due to hypokalemia from laxative abuse because diarreha cause hypokamlemia and also cause incrase in renin angiotensin sytem which will further cause hypokalemia resuling cardiocascular colapse :)
+1
hyperfukus
i thought the hyperuricemia thing too but i wasn't smart enough to think they wanted hypokalemia like u :(
+2
You must be logged in to vote!
waterloo
I Dont know what you mean by low EVV. But here's my thought process.
This pt lost lots of water, and when someone takes a laxative causing them to have diarrhea that will lead to metabolic acidosis. A buffering mechanism for the decreased bicarb in the blood is for H+ to leave cells and K+ to go into the cells. So he has to have hypokalemia (low K+ in serum). They gave him IV fluids, so his BP should be headed back to normal. I would think his RAAS will chill out. But it takes time to correct the acidosis, you're kidney won't just immediately stop reabs bicarb so you're body will still be buffering against the acidosis (H+ out of cell, K+ in).
+2
waterloo
sorry, I wrote increased bicarb, I meant DECREASED bicarb in the blood. And also should have written "you're kidney won't just immediately START reabs new bicarb" My Bad, wasn't trying to add to confusion.
+1
drdoom
i think by `EVV` author meant `ECV` (extracellular volume). @waterloo, appreciate the explanation but think something is off: loss of HCO3- via diarrhea should result in acidemia, which would oppose the presumption of ``H+ leaving cell, K+ going in´´.
+2
waterloo
hey so sorry, I must have been super tired posting this. Can't believe I made so many mistakes. Read over it again, and it sounds like gibberish. Wish there was a way to delete. My bad.
+1
waterloo
I think I tried to explain too hard. Looking at this question again, I think really the only this is when you lose that much volume, you lose bicarb and K+. Nothing really to do with acid-base. My b.
+1
castlblack
EVV = effective vascular volume. Thank you for trying to help but I still don't understand. I still agree with my above mechanism as correct. Whether or not it's most correct idk.
+1
amy
what about the long steamy bath? He also sweat a lot, and profuse sweating is going to cause hyponatremia?
+1
helppls
thats what I was thinking as well^^^ I figured he was sweating out a lot of NaCl
+1
icrieeverytiem
The Q mentions that he feels better after an infusion of fluids so I assumed any hyponatremia that he had must've been resolved.
+1
You must be logged in to vote!
You must be logged in to vote!
submitted by ∗moloko270(77)
loss of fluid triggers aldosterone production, so patient will have hypernatremia and hypokalemia as a result